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Primary Progressive Aphasia

A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)
Also Known As:
Aphasia, Primary Progressive; Mesulam's Syndrome; Aphasias, Primary Progressive; Primary Progressive Aphasias; Progressive Aphasia, Primary; Progressive Aphasias, Primary; Syndrome, Mesulam; Syndrome, Mesulam's; Mesulam Syndrome
Networked: 75 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Dementia (Dementias)
3. Frontotemporal Dementia
4. Frontotemporal Lobar Degeneration (Semantic Dementia)
5. Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)

Experts

1. Weintraub, Sandra: 8 articles (04/2014 - 11/2004)
2. Duffy, Joseph R: 5 articles (02/2016 - 05/2010)
3. Josephs, Keith A: 5 articles (02/2016 - 05/2010)
4. Whitwell, Jennifer L: 5 articles (02/2016 - 05/2010)
5. Masullo, Carlo: 5 articles (01/2012 - 02/2006)
6. Seripa, Davide: 5 articles (01/2012 - 02/2006)
7. Rademaker, Alfred: 5 articles (04/2011 - 12/2006)
8. Johnson, Nancy: 5 articles (04/2011 - 12/2005)
9. Strand, Edythe A: 4 articles (03/2015 - 05/2010)
10. Miller, Bruce L: 4 articles (08/2014 - 10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primary Progressive Aphasia:
1. TNFR-Fc fusion protein (etanercept)FDA Link
2. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
3. Amyloid (Amyloid Fibrils)IBA
4. ApolipoproteinsIBA
5. Apolipoproteins E (ApoE)IBA
6. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
7. Memantine (Namenda)FDA Link
8. N- methyl- 2- (4'- methylaminophenyl)- 6- hydroxybenzothiazoleIBA
9. Biological Markers (Surrogate Marker)IBA
10. protein TDP-43 (TDP-43)IBA

Therapies and Procedures

1. Vasectomy (Vas Occlusion)
2. Language Therapy (Language Training)
3. Activities of Daily Living (ADL)
4. Speech Therapy (Therapy, Speech)