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Landau-Kleffner Syndrome

A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495).
Also Known As:
Acquired Aphasia with Convulsive Disorder; Acquired Epileptiform Aphasia; Aphasia, Acquired, With Convulsive Disorder; Aphasia, Epileptic, Acquired; Landau-Kleffner Acquired Epileptiform Aphasia; Acquired Epileptic Aphasia; Acquired Epileptic Aphasias; Acquired Epileptiform Aphasias; Epileptic Aphasia, Acquired; Epileptic Aphasias, Acquired; Epileptiform Aphasia, Acquired; Epileptiform Aphasias, Acquired; Landau Kleffner Acquired Epileptiform Aphasia; Landau Kleffner Syndrome; Syndrome, Landau-Kleffner; Acquired Childhoood Aphasia with Convulsive Disorder; Aphasia, Acquired Epileptic
Networked: 60 relevant articles (6 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Agnosia (Visual Agnosia)
2. Epilepsy (Aura)
3. Aphasia (Dysphasia)
4. Partial Epilepsies (Epilepsy, Partial)
5. Landau-Kleffner Syndrome

Experts

1. Mikati, Mohamad A: 2 articles (03/2016 - 04/2002)
2. Catsman-Berrevoets, Coriene E: 2 articles (09/2015 - 08/2009)
3. Devinsky, Orrin: 2 articles (10/2014 - 01/2008)
4. Cohen, Amnon: 1 article (01/2020)
5. Granata, Tiziana: 1 article (01/2020)
6. Moresco, Luca: 1 article (01/2020)
7. Ragona, Francesca: 1 article (01/2020)
8. Siri, Laura: 1 article (01/2020)
9. Fainberg, Nina: 1 article (03/2016)
10. Harper, Amy: 1 article (03/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Landau-Kleffner Syndrome:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
2. SteroidsIBA
3. Adrenocorticotropic Hormone (ACTH)FDA Link
4. Intravenous Immunoglobulins (IVIG)FDA Link
5. BenzodiazepinesIBA
6. Glucose (Dextrose)FDA LinkGeneric
7. Immunoglobulins (Immunoglobulin)IBA
8. Anticonvulsants (Antiepileptic Drugs)IBA
9. Valproic Acid (Depakote)FDA LinkGeneric
10. VigabatrinFDA Link

Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Sign Language
4. Ketogenic Diet
5. Immunotherapy