Landau-Kleffner Syndrome

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38 relevant articles (3 outcomes, 3 trials/studies) found for this Disease

Description: A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495)

Also Known As:

Aphasia, Epileptic, Acquired; Landau-Kleffner Acquired Epileptiform Aphasia; Acquired Epileptic Aphasia; Acquired Epileptic Aphasias; Aphasias, Acquired Epileptic; Epileptic Aphasia, Acquired; Epileptic Aphasias, Acquired; Landau Kleffner Acquired Epileptiform Aphasia; Landau Kleffner Syndrome; Syndrome, Landau-Kleffner; Acquired Childhoood Aphasia with Convulsive Disorder; Aphasia, Acquired Epileptic

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3406

Central Nervous System Diseases: 929

Brain Diseases: 1117

Epilepsy: 13892

Landau-Kleffner Syndrome: 38

Related Diseases

1.	Epilepsy (Aura)
2.	Syndrome
3.	Aphasia (Dysphasia)
4.	Partial Epilepsies (Epilepsy, Partial)
5.	Infantile Spasms (West Syndrome)
19 Diseases and 21 more articles analyzed in the Research Interface, order at left...

Experts

1.	Barale, Francesco: 1 article (01/2007)
2.	Alfei, Enrico: 1 article (01/2007)
3.	Fusar-Poli, Paolo: 1 article (01/2007)
4.	Cortesi, Mariachiara: 1 article (01/2007)
5.	Deuel, Ruth Mary K: 1 article (02/2006)
6.	Chez, Michael: 1 article (02/2006)
7.	Robinson, Ricki G: 1 article (02/2006)
8.	Kwon, Jennifer M: 1 article (02/2006)
9.	Golumbek, Paul T: 1 article (02/2006)
10.	Keeling, Richard M: 1 article (02/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Landau-Kleffner Syndrome:

1.	Intravenous Immunoglobulins (IVIG)FDA Link 04/01/2002 - "This finding suggests that IVIG has at least some efficacy for the therapy of Landau-Kleffner syndrome." 07/01/2000 - "CONCLUSIONS: Repeated, immediate, and remarkable clinical and EEG responses of this patient suggest that IVIG was helpful as first-line therapy in the treatment of Landau-Kleffner syndrome" 11/01/1998 - "IVIG in Landau-Kleffner syndrome." 02/01/1998 - "Successful use of intravenous immunoglobulins in Landau-Kleffner syndrome." 10/01/2003 - "Many cases of drug-resistant infantile epilepsy (West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, severe myoclonic epilepsy, and Rasmussen's encephalitis) were found to respond in some measure to treatments with intravenous immunoglobulins (IVIG), but relapses were common" Get all the results and reference details, order at left...
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/01/2005 - "Corticosteroids are a safe and effective treatment for patients with Landau-Kleffner syndrome and CSWS" 05/01/2005 - "Corticosteroids should be considered as a treatment option in children with Landau-Kleffner syndrome and CSWS." 05/01/2005 - "We describe our experience in treating patients with Landau-Kleffner syndrome and CSWS with corticosteroids" 05/01/2005 - "Corticosteroids for the treatment of Landau-kleffner syndrome and continuous spike-wave discharge during sleep." 11/01/1990 - "Five children with Landau-Kleffner syndrome (epilepsy, acquired aphasia, and continuous spike-wave discharges during sleep), were treated with antiepileptic drugs (AEDs), sleep-modifying drugs, and corticosteroids" Get all the results and reference details, order at left...
3.	Immunoglobulins (Immunoglobulin)IBA 04/01/2002 - "Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome." 07/01/2000 - "Successful use of intravenous immunoglobulin as initial monotherapy in Landau-Kleffner syndrome." 07/01/2000 - "In this article we present the first case in which a patient with Landau-Kleffner syndrome was given intravenous immunoglobulin (IVIG) as his first and only therapy and responded to it" Get all the results and reference details, order at left...
4.	Glucose (Dextrose)FDA LinkGeneric 03/01/1995 - "In order to investigate differences in glucose metabolic patterns between awake and sleep states in two children with Landau-Kleffner syndrome and continuous spike-waves during slow-wave sleep, fluorodeoxyglucose positron-emission tomographic (PET) studies were performed in each state" 11/01/1990 - "Cerebral glucose utilization during sleep in Landau-Kleffner syndrome: a PET study." 11/01/1990 - "Our data demonstrate that in Landau-Kleffner syndrome, cerebral glucose utilization is not normal during sleep" 11/01/1997 - "We have evaluated 17 children (aged 2.4 to 10.6 yr) with Landau-Kleffner syndrome using positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in order to determine whether there are metabolic abnormalities common to this syndrome" 03/01/1994 - "Regional brain glucose utilisation was investigated with PET and fluorodeoxyglucose (FDG) in a case of epileptic aphasia (Landau-Kleffner syndrome) associated with a left sylvian arachnoid cyst" Get all the results and reference details, order at left...
5.	Anticonvulsants (Antiepileptic Drugs)IBA 01/15/2005 - "Data on the use of different antiepileptic drugs (AED) in Landau-Kleffner syndrome and in ESES is contradictory, but it has been proved that courses of polytherapy clearly have a harmful effect" 02/01/2000 - "Two children with Landau-Kleffner syndrome were successfully treated with antiepileptic drugs and a high-dose intravenous corticosteroid" 11/01/1990 - "Five children with Landau-Kleffner syndrome (epilepsy, acquired aphasia, and continuous spike-wave discharges during sleep), were treated with antiepileptic drugs (AEDs), sleep-modifying drugs, and corticosteroids" Get all the results and reference details, order at left...
6.	VigabatrinIBA 05/01/1993 - "Vigabatrin in the Landau-Kleffner syndrome." 11/01/1993 - "The use of vigabatrin in idiopathic localization-related epilepsy, idiopathic generalized epilepsy, and the Landau Kleffner syndrome have not been reported, but its evaluation in these conditions may be warranted based on the relatively excellent safety profile of vigabatrin" Get all the results and reference details, order at left...
7.	gamma-Globulins (gamma-Globulin)IBA 04/01/1997 - "Landau-Kleffner syndrome: consistent response to repeated intravenous gamma-globulin doses: a case report." 04/01/2002 - "We administered 2 gm/kg of intravenous gamma globulin (IVIG) to each of five consecutive patients with Landau-Kleffner syndrome, over 4 days" Get all the results and reference details, order at left...
8.	Nerve Growth Factor (NGF)IBA 01/01/2007 - "Linking autism, regression and Landau-Kleffner syndrome: integrative role of nerve growth factor." Get all the results and reference details, order at left...
9.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/01/1990 - "Three right-handed male children (aged 5, 6, and 11 years) with signs, symptoms and/or history of the syndrome of acquired aphasia-epilepsy (Landau-Kleffner syndrome) were studied during drug-induced, electroencephalographically (EEG)-monitored sleep by positron-emission tomography (PET) and the [18F]fluorodeoxyglucose (FDG) method" Get all the results and reference details, order at left...
10.	Brain-Derived Neurotrophic Factor (BDNF)IBA 02/15/2006 - "Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy." 02/15/2006 - "METHODS: BDNF levels and IgG/IgM autoantibodies to BDNF, ECs, MBP, and histones were measured in children with autism, childhood disintegrative disorder (CDD), pervasive developmental delay-not otherwise specified (PDD-nos), acquired epilepsy, Landau-Kleffner syndrome (LKS); healthy children (HC), and children with non-neurological illnesses (NNI)" Get all the results and reference details, order at left...
33 Drugs and Important Bio-Agents and 33 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Aftercare (After-Treatment) 12/01/1999 - "Landau-Kleffner syndrome: relation of clinical, EEG and Tc-99m-HMPAO brain SPECT findings and improvement in EEG after treatment." Get all the results and reference details, order at left...
2.	Sign Language 06/01/2001 - "Accessibility of spoken, written, and sign language in Landau-Kleffner syndrome: a linguistic and functional MRI study." 04/01/2004 - "The use of sign language in the treatment of patients with verbal aphasia is considered, especially of children with the Landau-Kleffner syndrome, but therapy of this kind can be used in children with delayed language development, and in other types of acquired aphasia at any age" 11/01/2001 - "Sign language in childhood epileptic aphasia (Landau-Kleffner syndrome)." 07/01/1998 - "We report a 27-year-old woman with chronic auditory agnosia following Landau-Kleffner Syndrome (LKS) diagnosed at age 4 1/2. She grew up in the hearing/speaking community with some exposure to manually coded English and American Sign Language (ASL)" Get all the results and reference details, order at left...
2 Therapies and Procedures and 5 more articles analyzed in the Research Interface, order at left...

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