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Sneddon Syndrome (Syndrome, Sneddon)

A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of LIVEDO RETICULARIS, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60). Mutations in the CECR1 gene (ADA2 protein, human) are associated with Sneddon syndrome.
Also Known As:
Syndrome, Sneddon; Livedo Reticularis And Cerebrovascular Accidents; Sneddon Champion Syndrome; Syndrome, Sneddon-Champion; Livedo Reticularis, Systemic Involvement; Sneddon-Champion Syndrome
Networked: 46 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1. Thrombosis (Thrombus)
2. Stroke (Strokes)
3. Hypertension (High Blood Pressure)
4. Arterial Occlusive Diseases (Arterial Occlusive Disease)
5. Livedo Reticularis

Experts

1. Jiménez-Gallo, David: 2 articles (01/2016 - 03/2014)
2. Linares-Barrios, Mario: 2 articles (01/2016 - 03/2014)
3. Cervera, Alvaro: 1 article (03/2021)
4. Chamorro, Angel: 1 article (03/2021)
5. Greisenegger, Elli Katharine: 1 article (03/2021)
6. Greisenegger, Stefan: 1 article (03/2021)
7. Henes, Jörg: 1 article (03/2021)
8. Jimenez-Escrig, Adriano: 1 article (03/2021)
9. Joutel, Anne: 1 article (03/2021)
10. Kopp, Tamara: 1 article (03/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sneddon Syndrome:
1. Antiphospholipid AntibodiesIBA
2. AntibodiesIBA
3. Anticardiolipin AntibodiesIBA
4. Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA
5. Retinaldehyde (Retinal)IBA
6. Immunoglobulin M (IgM)IBA
7. Cardiolipins (Cardiolipin)IBA
8. Phospholipids (Phosphatides)FDA LinkGeneric
9. Antigen-Antibody Complex (Immune Complex)IBA
10. factor V LeidenIBA

Therapies and Procedures

1. Therapeutics
2. Transcatheter Aortic Valve Replacement
3. Thyroidectomy
4. Bioprosthesis