Cyclin-Dependent Kinases (cdk Proteins)

Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.

Also Known As:

cdk Proteins; Cyclin-Dependent Protein Kinases; Cyclin Dependent Kinase; Cyclin Dependent Kinases; Cyclin Dependent Protein Kinase; Cyclin Dependent Protein Kinases; Kinase, Cyclin-Dependent; Kinase, Cyclin-Dependent Protein; Protein Kinase, Cyclin-Dependent; Cyclin-Dependent Kinase; Cyclin-Dependent Protein Kinase

Networked: 4005 relevant articles (94 outcomes, 329 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Grant, Steven: 21 articles (03/2014 - 02/2002)
2.	Meijer, Laurent: 16 articles (01/2018 - 07/2002)
3.	Duan, Zhenfeng: 15 articles (05/2022 - 01/2014)
4.	Kilstrup-Nielsen, Charlotte: 13 articles (01/2022 - 10/2006)
5.	Wesierska-Gadek, Józefa: 13 articles (01/2011 - 01/2006)
6.	Shapiro, Geoffrey I: 12 articles (10/2021 - 04/2006)
7.	Dent, Paul: 12 articles (12/2007 - 09/2002)
8.	Senderowicz, Adrian M: 12 articles (01/2005 - 01/2002)
9.	Gray, Nathanael S: 11 articles (01/2022 - 07/2012)
10.	Park, David S: 11 articles (01/2019 - 10/2001)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2021 - "Although cell cycle cyclin-dependent kinase (CDK) 4/6 inhibitors are approved for treatment of ER-positive (ER+) breast cancer, they have not proven effective as monotherapy in patients with TNBC. " 08/19/2023 - "Cyclin-dependent kinase (CDK) 4/6 inhibitors have significantly improved overall and progression free survival of patients with metastatic breast cancer, but their effect on short and long-term kidney function is unknown. " 12/01/2022 - "Cyclin-dependent kinase (CDK) 4/6 inhibitors are used as a novel treatment standard not only in pretreated patients but also in the first-line setting of HR+ metastatic breast cancer (MBC). " 01/01/2020 - "Here, we describe a novel treatment strategy that targets cyclin-dependent kinase 7 (CDK7) in HER2 inhibitor-resistant (HER2iR) breast cancer. " 10/01/2023 - "Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) have been shown to improve progression-free survival (PFS) in patients with metastatic breast cancer (MBC) in randomized control trials. "
2.	Neoplasms (Cancer) 04/01/2012 - "In recent years, therapeutic approaches such as p53 reactivation, inhibition of c-MYC in addicted tumors or treatment with cyclin-dependent kinase (CDK) inhibitors have proven effective by invoking a senescence response. " 03/26/2022 - "Transcriptional cyclin-dependent kinases (CDK) have been shown to be effective targets in the treatment of different types of cancer. " 01/01/2021 - "The covalent cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 interferes with transcription machinery and is reported to be effective in cancers without targetable mutations. " 01/01/2019 - "Methods that reactivate the RB pathway using inhibitors of cyclin-dependent kinases CDK4 and CDK6 are effective in some cancer types and are currently under evaluation for the treatment of lung adenocarcinoma7-9. " 06/01/2012 - "Diaminothiazoles are a class of compounds that have been reported to show promise in the treatment of cancer by inhibiting cancer cell proliferation and inducing apoptosis, because of their effects on microtubules and as inhibitors of cyclin-dependent kinases. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/01/2006 - "Chemical inhibitors of cyclin-dependent kinases have great therapeutic potential against various proliferative and neurodegenerative disorders. " 09/19/2002 - "Chemical inhibitors of cyclin-dependent kinases (CDKs) have a great therapeutic potential against various proliferative and neurodegenerative disorders. " 06/01/2000 - "Chemical inhibitors of cyclin-dependent kinases (CDKs) have great therapeutic potential against various proliferative and neurodegenerative disorders. " 01/01/2023 - "Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. " 12/01/2019 - "Aberrant activity of cyclin-dependent kinase (Cdk)5 is implicated in a number of neurodegenerative diseases. "
4.	Multiple Myeloma 01/01/1997 - "To study the structural integrity of the cyclin-dependent kinase inhibitors known as INK4A (p16), INK4B (p15) and INK4C (p18) in multiple myeloma, we examined 20 primary myeloma samples (including one case of plasma cell leukaemia) using polymerase chain reaction-single strand conformation polymorphism, and 17 samples were examined by Southern blot analysis. " 06/01/2020 - "The emergence of new drugs is a major feature of the treatment history of multiple myeloma (MM), which also reflects the current incurability of MM. As a unique member of cyclin dependent kinase (CDK) family, CDK5 participates in numerous tumorigenic or non‑tumorigenic processes. " 02/01/2016 - "Cyclin-dependent kinases (CDK), upstream modulators of HR, are dysregulated in multiple myeloma. " 10/01/2014 - "Inhibitors of cyclin-dependent kinases 9 have been developed as potential anticancer drugs for the treatment of multiple myeloma. " 05/01/2012 - "Interestingly, cyclin-dependent kinases (CDKs) have also been proposed as therapeutic targets for Multiple Myeloma (MM). "
5.	Retinoblastoma (Glioblastoma, Retinal) 10/05/2021 - "Differences in the number of cyclin-dependent kinases and potential retinoblastoma phosphorylation sites between the A and B races were found. " 02/28/2021 - "The planned work of the current research will illuminate the arrested phase in the cell cycle through studying tumor suppressor genes such as p53 and Retinoblastoma RB, c-Myc oncogene, and cyclin-dependent kinases (Cdks) as well as their regulators." 02/01/2020 - "Furthermore, extracellular rhAIF-1 (6 nM) increased the survival of naive and effector T cells during Th1 polarization by inhibition of apoptosis, without causing changes in cell cycle rate and in retinoblastoma-cyclin-dependent kinase (Rb-CDK) activation. " 01/01/2020 - "Retraction for Braden et al., "Distinct Action of the Retinoblastoma Pathway on the DNA Replication Machinery Defines Specific Roles for Cyclin-Dependent Kinase Complexes in Prereplication Complex Assembly and S-Phase Progression"." 08/01/2018 - "Taken together, our findings suggest that IRS-4 promotes retinoblastoma-cyclin-dependent kinase activation and it may serve as a pharmacological target since its expression is very low in normal tissue, including colonic epithelium."

Related Drugs and Biologics

1.	Hormones (Hormone)
2.	palbociclib
3.	Roscovitine
4.	human ERBB2 protein
5.	Estrogen Receptors
6.	alvocidib (flavopiridol)
7.	ErbB Receptors (EGF Receptor)
8.	Proteins (Proteins, Gene)
9.	Cyclin D1
10.	ribociclib

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Craniospinal Irradiation
5.	Transplantation