Chaperonin 60

A group I chaperonin protein that forms the barrel-like structure of the chaperonin complex. It is an oligomeric protein with a distinctive structure of fourteen subunits, arranged in two rings of seven subunits each. The protein was originally studied in BACTERIA where it is commonly referred to as GroEL protein.

Also Known As:

Networked: 509 relevant articles (13 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wick, G: 10 articles (01/2017 - 03/2000)
2.	Wick, Georg: 10 articles (01/2017 - 01/2003)
3.	Prakken, Berent J: 9 articles (01/2013 - 07/2002)
4.	Yamazaki, K: 7 articles (04/2014 - 05/2000)
5.	Albani, Salvatore: 7 articles (10/2012 - 07/2002)
6.	Cappello, Francesco: 6 articles (01/2022 - 10/2005)
7.	de Jager, Wilco: 6 articles (01/2016 - 07/2005)
8.	Henderson, Brian: 6 articles (12/2014 - 04/2005)
9.	Oguma, Keiji: 6 articles (11/2009 - 01/2004)
10.	Wang, Feng-Sheng: 5 articles (01/2022 - 01/2016)

Related Diseases

1.	Infections 10/01/2022 - "Moreover, immunization of the mice with recombinant GroEL protein conferred 80 and 60% protection against lethal infections by EPEC and EHEC, respectively. " 01/01/2008 - "Immunization of mice with recombinant groEL protein with or without adjuvant conferred 70-90% protection against lethal infections either by S. " 09/01/1997 - "Heat shock protein 60 (hsp60)-specific CD8 T cells lysed Mycobacterium bovis BCG-infected macrophages in vitro and adoptively transferred protection against mycobacterial infection. " 11/16/2023 - "The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection." 01/01/2023 - "We taxonomically affiliated our isolates at the species level through the partial sequencing of the heat shock protein 60 gene and estimated their virulence potential through experimental infection of juvenile C. "
2.	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 07/01/2011 - "Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis." 11/01/1996 - "Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis." 01/01/2009 - "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?" 07/01/2003 - "To test the hypothesis that T cell reactivity to self heat-shock protein 60 (Hsp60) in patients with remitting juvenile idiopathic arthritis (JIA) is part of an antiinflammatory, regulatory mechanism. " 12/01/2011 - "In juvenile idiopathic arthritis, however, T cell recognition of a so-called bystander antigen, heat shock protein 60 (HSP60), is associated with a good prognosis. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/01/1998 - "We believe our results represent strong evidence that B cells are required as APCs to generate pathogenic autoimmune T cell responses and provide a direct correlation between the protection from autoimmune diabetes previously reported in B cell-deficient NOD mice and the lack of anti-GAD65 and anti-heat shock protein 60 T cell responses in these mice." 02/01/2010 - "DiaPep277, the major T-cell epitope of heat shock protein 60 (hsp60), has been shown to be effective as a modulator of the immune system in type 1 diabetes and is the focus of this review. " 01/01/2017 - "A functional 24-residue peptide derived from heat shock protein 60 (P277) has shown anti-type 1 diabetes mellitus potential in experimental animals and in clinical studies, but it also carries a potential atherogenic effect. " 01/01/2017 - "Recent studies have investigated the potential of type 1 diabetes mellitus-related autoantigens, such as heat shock protein 60, to induce immunological tolerance or to suppress the immune response. " 06/01/2016 - "Human heat shock protein 60 (Hsp60), is an endogenous β-cells autoantigen, it could postpone the onset of insulitis and sooner type 1 diabetes mellitus. "
4.	Inflammation (Inflammations) 06/09/2018 - "Our previous study suggests the critical role of heat shock protein 60 (HSP60) in IL-1β-induced inflammation in microglia through TLR4-p38 MAPK axis. " 01/01/2018 - "Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese." 12/01/2001 - "Heat shock protein (60 kd HSP) has been implicated in the etiology of Behçet's disease, but its expression at sites of inflammation is unknown. " 01/05/2022 - "Heat Shock Protein 60 Restricts Release of Mitochondrial dsRNA to Suppress Hepatic Inflammation and Ameliorate Non-Alcoholic Fatty Liver Disease in Mice." 01/01/2018 - "Pn infection is also capable of triggering the secretion of Chlamydial Heat Shock Protein 60 (cHSP60) in the vessel wall resulting in augmentation of inflammation. "
5.	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 03/01/2000 - "Some study results indicate that mucosal tolerance induced by appropriate recombinant peptide fragments of human AChR is effective in suppressing experimental autoimmune myasthenia gravis and might be considered as a therapeutic modality for patients with MG. A peptide of the heat-shock protein 60 molecule, designated peptide p277, was shown to be a target of T cells in autoimmune diabetes in NOD mice, and intraperitoneal injections of glutamic acid decarboxylase (GAD) peptide 524-543 delayed the onset of diabetes and significantly reduced its incidence. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Heat-Shock Proteins (Heat-Shock Protein)
3.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
4.	Cytokines
5.	Peptide Fragments
6.	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)
7.	Interleukin-10 (Interleukin 10)
8.	Interferon-gamma (Interferon, gamma)
9.	Bacterial Antigens
10.	Imiquimod (Aldara)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Therapeutics
3.	Immunotherapy
4.	Intranasal Administration
5.	Bariatric Surgery