Bacterial Adhesins

Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.

Also Known As:

Networked: 94 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dobrindt, Ulrich: 2 articles (01/2016 - 04/2006)
2.	Hauck, Christof R: 2 articles (01/2016 - 01/2009)
3.	Race, Paul R: 2 articles (01/2016 - 07/2007)
4.	Magalhães, A: 2 articles (11/2013 - 07/2010)
5.	Reis, C A: 2 articles (11/2013 - 07/2010)
6.	Hacker, J: 2 articles (01/2009 - 02/2000)
7.	Khan, A S: 2 articles (01/2009 - 02/2000)
8.	Basak, Aditya J: 1 article (01/2021)
9.	Chatterjee, Shruti: 1 article (01/2021)
10.	Davies, Peter L: 1 article (01/2021)

Related Diseases

1.	Whooping Cough (Pertussis) 01/01/2017 - " Bordetella pertussis strains lacking expression of pertactin, a bacterial adhesin and vaccine target, are emerging. " 01/01/1993 - "These antibodies are very useful probes to identify the presence of FHA in bordetellae species and in clinical reagents such as pertussis vaccines, and to characterize the functional domains of this important bacterial adhesin."
2.	Bacterial Meningitis 06/01/2009 - "Together, these findings suggest that disruption or modulation of the interaction of bacterial adhesins with LR might engender unexpectedly broad protection against bacterial meningitis and may provide a therapeutic target for the prevention and treatment of disease."
3.	Infections 12/01/2000 - "We demonstrate a convenient technique for quantification of bacterial adhesins that can be used in studies aimed at characterization of bacterial adhesion to ECM components and understanding expression of adhesins during the course of an infection." 01/01/2017 - "One such approach centers around FimH antagonists that block the bacterial adhesin FimH, which would otherwise mediate binding of uropathogenic Escherichia coli to the host urothelium to trigger the infection. " 01/01/2016 - "Collectively, these findings establish a new bacterial adhesin structure that has in effect been hijacked by a pathogenic Streptococcus species to provide competitive advantage in human mucosal infections." 01/01/2016 - "These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. " 08/01/2013 - "Staphylococcus aureus, the leading causal pathogen of skin infections, is strongly associated with skin atopy, and a number of bacterial adhesins allow the microbe to adhere to and invade eukaryotic cells. "
4.	Urinary Tract Infections (Urinary Tract Infection) 06/01/1986 - "In studies on bacterial adherence and urinary tract infections, both in vivo and in vitro studies may contribute to understanding the relevance of bacterial adhesins in initiating urinary tract infections." 07/10/2020 - "Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that allow the establishment of urinary tract infections (UTIs). " 11/01/2018 - "mirabilis fimbrial adhesins and their roles in the complex pathogenesis of urinary-tract infections." 12/01/2011 - "Escherichia coli, a cause of ∼90% of urinary tract infections (UTI), utilizes fimbrial adhesins to colonize the uroepithelium. " 03/01/1998 - "[Urinary tract infection: bacterial adhesin and biofilm formation]."
5.	Sepsis (Septicemia) 03/01/2012 - "Previous studies have shown that in vitro oxidation of Met1606 hinders vWF cleavage by ADAMTS-13, resulting in the accumulation of UL-vWF that are not only more pro-thrombotic than shorter vWF oligomers, but also more efficient in binding to bacterial adhesins during sepsis. " 07/01/2004 - "F165(1) (foo) and CS31A (clp) are bacterial adhesins synthesized by Escherichia coli strains associated with diarrhea and septicemia in piglets and calves. " 01/01/1989 - "Possible role of bacterial adherence and bacterial adhesins in sepsis and septic shock." 03/01/1990 - "Fimbrial adhesins and hemolysins contribute to pathogenicity of extraintestinal Escherichia coli isolates causing urinary tract infections (UTI), sepsis and new born meningitis (NBM). "

Related Drugs and Biologics

1.	Vaccines
2.	Antibodies
3.	Indicators and Reagents (Reagents)
4.	Proteins (Proteins, Gene)
5.	Virulence Factors (Pathogenicity Factors)
6.	Hemolysin Proteins (Hemolysins)
7.	Peptides (Polypeptides)
8.	Glycoproteins (Glycoprotein)
9.	Enterotoxins (Enterotoxin)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics