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Thyroid-Stimulating Immunoglobulins

Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.
Also Known As:
Immunoglobulins, Thyroid-Stimulating; Immunoglobulin, Thyroid-Stimulating; Thyroid Stimulating Antibody; Thyroid-Stimulating Immunoglobulin; Antibody, Thyroid Stimulating; Autoantibody, Thyroid-Stimulating; Immunoglobulin, Thyroid Stimulating; Stimulating Antibody, Thyroid; Thyroid Stimulating Antibodies; Thyroid Stimulating Autoantibodies; Thyroid Stimulating Autoantibody; Thyroid Stimulating Immunoglobulin; Thyroid Stimulating Immunoglobulins; Thyroid Stimulating, Ig; Antibodies, Thyroid-Stimulating; Ig Thyroid Stimulating; Thyroid-Stimulating Antibodies; Thyroid-Stimulating Autoantibodies; Thyroid-Stimulating Autoantibody
Networked: 629 relevant articles (28 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. McLachlan, Sandra M: 15 articles (04/2016 - 07/2002)
2. Rapoport, Basil: 15 articles (04/2016 - 07/2002)
3. Chen, Chun-Rong: 9 articles (01/2015 - 07/2002)
4. Banga, J Paul: 7 articles (12/2018 - 01/2003)
5. McLachlan, S M: 6 articles (04/2010 - 05/2001)
6. Rapoport, B: 6 articles (04/2010 - 05/2001)
7. Nagayama, Yuji: 6 articles (12/2007 - 03/2002)
8. Ludgate, Marian: 5 articles (10/2021 - 02/2012)
9. Kahaly, G J: 5 articles (07/2015 - 05/2010)
10. Zhang, Lei: 4 articles (10/2021 - 02/2012)

Related Diseases

1. Graves Disease (Basedow Disease)
2. Hyperthyroidism
3. Graves Ophthalmopathy
03/01/2022 - "There was a statistically significant reduction in Clinical Activity Score, Thyroid-Associated Ophthalmopathy Scale score, and thyroid-stimulating immunoglobulin levels when comparing pre-treatment values (mean Clinical Activity Score 6.78 ± 1.09, mean Thyroid-Associated Ophthalmopathy Scale score 10.2 ± 1.92, mean thyroid-stimulating immunoglobulin level 440.6 [%]) to values immediately following completion of treatment (mean Clinical Activity Score 0.44 ± 0.53, mean difference 6.3 points, p < 0.001 [95% CI, 5.5-7.2]; mean Thyroid-Associated Ophthalmopathy Scale score 1.2 ± 1.09, mean difference 9.0 points, p < 0.001 [95% CI, 7.2-10.8]; mean thyroid-stimulating immunoglobulin level 200.7 [%], mean difference 239.9 [%], p = 0.001 [95% CI, 124.3-355.4]). "
08/01/1996 - "Studies of retroorbital tissue xenografts from patients with Graves' ophthalmopathy in severe combined immunodeficient (SCID) mice: detection of thyroid-stimulating antibody."
12/01/1984 - "The application of a cytochemical bioassay to measure thyroid stimulating antibodies; a study of patients with euthyroid Graves' ophthalmopathy."
01/01/2023 - "Although it has been reported that thyroid-stimulating immunoglobulin (TSI) is associated with the clinical characteristics of thyroid eye disease (TED), there is a paucity of literature regarding the role of TSI in diagnosing active TED. "
01/01/2022 - "Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease."
4. Goiter
5. Thyrotoxicosis

Related Drugs and Biologics

1. Antithyroid Agents (Antithyroid Drugs)
2. Immunoglobulins (Immunoglobulin)
3. Thyrotropin Receptors (Thyrotropin Receptor)
4. Antibodies
5. Thyrotropin (Thyroid-Stimulating Hormone)
6. Immunoglobulin G (IgG)
7. Thyroglobulin
8. anti-thyroglobulin
9. Polyethylene Glycols (Polyethylene Glycol)
10. Staphylococcal Protein A (Protein A)

Related Therapies and Procedures

1. Therapeutics
2. Thyroidectomy
3. Aftercare (After-Treatment)
4. Investigational Therapies (Experimental Therapy)
5. Transplantation