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alpha-Endorphin
An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 16-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from GAMMA-ENDORPHIN by one amino acid (beta-endorphin 1-17).
Also Known As:
beta-Endorphin (1-16); alpha Endorphin; Endorphin, alpha
Networked:
14
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
alpha-Endorphin: 14
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
alpha-Endorphin: 14
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Opioid Peptides: 1339
Endorphins: 977
alpha-Endorphin: 14
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
alpha-Endorphin: 14
Peptides: 82426
Neuropeptides: 6772
Opioid Peptides: 1339
Endorphins: 977
alpha-Endorphin: 14
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
alpha-Endorphin: 14
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
alpha-Endorphin: 14
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
alpha-Endorphin: 14
Experts
1.
Dong, Hua
: 1 article (11/2019)
2.
Han, Jing-Xian
: 1 article (11/2019)
3.
Wang, Jian-Wu
: 1 article (11/2019)
4.
Zhao, Hong-Yi
: 1 article (11/2019)
Related Diseases
1.
Neoplasms (Cancer)
03/01/1980 - "
Among 300 surgically removed pituitary adenomas, 17 tumors containing immunoreactive 1-39 adrenocorticotropin (ACTH) and/or 19-39 ACTH, beta-lipotropin, and alpha-endorphin but unassociated with clinical signs of Cushing's disease have been detected.
"
12/03/1987 - "
The expression of alpha-endorphin, [met]enkephalin-Arg-Gly-Leu, and dynorphin B varied from tumor to tumor; however, positive staining with the "pan-opioid" antibody was found in each tumor containing at least one of the three precursors.
"
07/01/1980 - "
The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic.
"
12/03/1987 - "
We looked for opioid peptides and their precursors in 108 tumors of both neuroendocrine and nonneuroendocrine origin, using a monoclonal "pan-opioid" antibody, 3-E7, which recognizes the tetrapeptide Tyr-Gly-Gly-Phe (the sequence responsible for pharmacologic activity in all known opioid peptides), in conjunction with polyclonal antibodies directed against representative peptides of each of the three precursors (alpha-endorphin, [met]enkephalin-Arg-Gly-Leu, and dynorphin B).
"
2.
Carcinoma (Carcinomatosis)
05/01/1978 - "
The immunoreactive (RIA), ACTH, LPH, alpha endorphin (alpha End) and beta End in an extract of a human pancreatic islet cell carcinoma causing the ectopic ACTH syndrome were assayed after gel exclusion chromatography.
"
07/01/1980 - "
Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin.
"
3.
Bradycardia
02/01/1991 - "
The parasympathetic bradycardia induced by the peripheral vagus stimulation was decreased by alpha-endorphin.
"
04/01/1978 - "
Leu- (1.8--180 nmol), met-enkephalin (17--520 nmol) and alpha-endorphin (5.7--57 nmol) administered in the same way produced preferential vasopressor effects and the latter two peptides also produced bradycardia.
"
4.
Pituitary ACTH Hypersecretion
03/01/1980 - "
Among 300 surgically removed pituitary adenomas, 17 tumors containing immunoreactive 1-39 adrenocorticotropin (ACTH) and/or 19-39 ACTH, beta-lipotropin, and alpha-endorphin but unassociated with clinical signs of Cushing's disease have been detected.
"
5.
Small Cell Carcinoma
05/01/1980 - "
Four months later lymph node and mediastinal metastases of an anaplastic small cell carcinoma, with the presence of argyrophil granulation, as well as immunoreactive 19-39ACTH, beta-LPH and alpha-endorphin, were found.
"
Related Drugs and Biologics
1.
Methionine Enkephalin
2.
Adrenocorticotropic Hormone (ACTH)
3.
beta-Lipotropin (Lipotropin)
4.
beta-Endorphin (Endorphin, beta)
5.
Peptides (Polypeptides)
6.
Leucine Enkephalin
7.
Therapeutic Uses
8.
Opioid Peptides (Opioid Peptide)
9.
gamma-Endorphin
10.
Substance P
Related Therapies and Procedures
1.
Aftercare (After-Treatment)