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Multiple Endocrine Neoplasia Type 2b (MEN 3)

Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Also Known As:
MEN 3; MEN2b; MEA 2b; MEA IIb; MEN III; MEN IIb; Mucosal Neuroma Syndrome; Multiple Endocrine Neoplasia, Type 2b; Multiple Endocrine Neoplasia, Type IIb; Multiple Endocrine Neoplasms Type 2b; Neuromata, Mucosal, With Endocrine Tumors; Wagenmann-Froboese Syndrome; Mucosal Neuroma Syndromes; Neuroma Syndrome, Mucosal; Syndrome, Wagenmann-Froboese; Wagenmann Froboese Syndrome; MEN 2b; Neoplasia, Multiple Endocrine Type 2b; Neoplasms, Multiple Endocrine Type 2b
Networked: 491 relevant articles (6 outcomes, 49 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Multiple Endocrine Neoplasia Type 2a (MEN 2)
2. Neuroma
3. Myocardial Infarction
4. Coronary Artery Disease (Coronary Atherosclerosis)
5. Abnormal Karyotype

Experts

1. Takahashi, M: 5 articles (04/2014 - 01/2000)
2. Piepponen, T Petteri: 4 articles (01/2018 - 05/2007)
3. Iwashita, T: 4 articles (04/2014 - 01/2000)
4. Moley, Jeffrey F: 4 articles (09/2013 - 05/2002)
5. Santoro, Massimo: 4 articles (12/2009 - 06/2002)
6. Melillo, Rosa Marina: 3 articles (01/2018 - 06/2002)
7. Waguespack, Steven G: 3 articles (01/2018 - 07/2005)
8. Ichihara, M: 3 articles (04/2014 - 02/2000)
9. Qiao, S: 3 articles (04/2014 - 02/2000)
10. Wells, Samuel A: 3 articles (08/2013 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Endocrine Neoplasia Type 2b:
1. vandetanib (ZD6474)IBA
2. CholesterolIBA
3. Vitamin EFDA LinkGeneric
4. Bendamustine HydrochlorideFDA Link
5. Codon (Codons)IBA
6. Calcitonin (Calcitonin, Eel)FDA LinkGeneric
7. Radioisotopes (Radionuclides)IBA
10/01/1984 - "Fifteen patients (12 men, 3 women, median age 47 years) who had abstained from alcohol drinking for at least 2 months were studied by exercise testing, echocardiography, measurement of systolic time intervals and left ventricular (LV) radionuclide ejection fraction (EF) at rest and during submaximal exercise. "
05/01/2000 - "Twenty-two patients with chronic heart failure (19 men, 3 women; mean age, 54 y; age range, 34-64 y) assessed as New York Hospital Association (NYHA) class II or III and with initial resting radionuclide LV ejection fractions (LVEF) < 0.40 were enrolled in the study. "
05/01/1998 - "Left ventricular (LV) function was studied noninvasively by serial equilibrium radionuclide angiocardiography and simultaneous measurement of peak power, a relatively afterload-independent index of LV contractility, in 21 patients with coronary artery disease (17 men, 4 women) and 9 normal subjects (6 men, 3 women) at baseline, during mental stress and during exercise. "
03/01/1996 - "Hypoxic and peripheral hypercapnic chemosensitivity were studied in 38 patients with chronic heart failure (35 men, 3 women; mean [+/-SE] age 60.2 +/- 1.3 years; radionuclide left ventricular ejection fraction 25.7 +/- 2.3%) and 15 healthy control subjects (11 men, 4 women; mean age 54.9 +/- 3.0 years) using transient inhalations of pure nitrogen and single breaths of 13% carbon dioxide, respectively. "
03/01/1998 - "This study examined the impact of exercise rehabilitation on cardiac neuronal function using iodine-123 metaiodobenzylguanidine (MIBG) scintigraphy, Fourteen patients (11 men, 3 women; mean age 48 years; range: 36-66 years) with stable chronic heart failure of NYHA class II-III and an initial resting radionuclide left ventricular ejection fraction (LVEF) < 50% were enrolled in the study. "
8. Dopamine (Intropin)FDA LinkGeneric
9. Protein Isoforms (Isoforms)IBA
10. Proteins (Proteins, Gene)FDA Link

Therapies and Procedures

1. Therapeutics
2. Radiofrequency Ablation
3. Thyroidectomy
4. Prostatectomy (Retropubic Prostatectomy)
05/01/1994 - "It is the cause of the commonest surgical procedure in older men (3 men in 10 may ultimately undergo prostatectomy). "
06/01/2015 - "The purpose of this study is to study the influence of radical prostatectomy (RP) for prostate cancer on work status and working life in men 3 years after surgery. "
01/01/1999 - "The twelve projects studied included: (1) a mass screening study using PSA as the initial test in 21,079 volunteers; (2) an investigation of the usefulness of normal and age-referenced PSA cut-offs in 1,618 men; (3) a PSA-based screening study of 2,272 asymptomatic blood donors; (4) an investigation of the evidence and significance of transition zone carcinoma in 340 men with negative digital rectal examination findings; (5) determination of percent free PSA in one retrospective and two prospective studies to determine the appropriate cutpoints for percent free PSA; (6) evaluation of the diagnostic benefit of PSA transition zone density in 308 screening volunteers; (7) a study of the impact of PSA-based screening on the percentage of incidental prostate carcinoma in 1, 543 men undergoing transurethral resection of the prostate; (8) an evaluation of the changes in total PSA and pathologic stages in radical prostatectomy over 5 years in a PSA-based mass screening program; (9) a study evaluating the probability of having prostate cancer given the patient's age, total PSA and digital rectal examination findings; (10) an evaluation of the correlation between preoperative predictors and pathologic features in radical prostatectomy specimens; (11) an investigation of the correlation of total PSA with pathologic stage and tumor volume in patients undergoing radical prostatectomy with low PSA cut-off level, and (12) a study whether age has an impact on the extension of prostate cancer. "
07/01/1993 - "In the present study these relationships were explored with nitric oxide synthase immunohistochemistry and reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemistry of select pelvic tissue specimens obtained from 4 men (3 at radical prostatectomy and 1 at autopsy). "
5. Vasectomy (Vas Occlusion)