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CD2 Antigens

Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.
Also Known As:
Antigens, CD2; CD2 Antigen; Antigen, CD2; Erythrocyte-Binding Glycoprotein, T11; T11 Erythrocyte Binding Glycoprotein; T11 Erythrocyte-Binding Glycoprotein
Networked: 30 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Valent, Peter: 3 articles (01/2006 - 02/2002)
2. Horny, Hans-Peter: 2 articles (07/2003 - 02/2002)
3. Lange, Magdalena: 1 article (01/2014)
4. Niedoszytko, Marek: 1 article (01/2014)
5. Wasąg, Bartosz: 1 article (01/2014)
6. Jassem, Ewa: 1 article (01/2014)
7. Nedoszytko, Bogusław: 1 article (01/2014)
8. Żawrocki, Anton: 1 article (01/2014)
9. Nowicki, Roman: 1 article (01/2014)
10. Żmijewski, Michał A: 1 article (01/2014)

Related Diseases

1. Systemic Mastocytosis
2. Neoplasms (Cancer)
12/01/1996 - "We examined the prognostic impact of CD2 antigen expression for 651 patients with T-lineage acute lymphoblastic leukemia (ALL), who were enrolled in front-line Childrens Cancer Group treatment studies between 1983 and 1994. "
04/01/1990 - "In two cases the tumor cells acquired the CD7 antigen or lost the CD2 antigen with progression of the disease. "
12/01/1996 - "CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group study."
06/01/1990 - "Our experiments explicitly show that: (a) crosslinkage of TCR with the CD2 antigen, and not independent crosslinking of TCR and of CD2 antigen or crosslinking of either protein with the CD4 or CD8 antigen induces significant proliferation independent of co-stimulatory signals (e.g., accessory cells, recombinant lymphokines, or tumor promoter), (b) F(ab')2 fragments of mAb directed at the TCR and F(ab')2 anti-CD2, crosslinked with F(ab')2 fragments of rabbit anti-mouse IgG, promote the proliferation of highly purified T cells, (c) a prompt and sustained increase in intracellular free Ca2+ concentration results from crosslinkage of TCR with the CD2 antigen, (d) T cell proliferation induced by this novel approach is curtailed by EGTA and by direct or competitive inhibitors of PKC, (e) crosslinkage of TCR with the CD2 antigen results in the transcriptional activation and translation of the gene for IL-2 and in the expression of IL-2 receptor alpha (CD25), (f) anti-CD25 mAbs inhibit T cell proliferation initiated by crosslinkage of TCR with the CD2 antigen, and recombinant IL-2 restores the proliferative response. "
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Infection
5. Histiocytic Necrotizing Lymphadenitis (Kikuchi Disease)

Related Drugs and Biologics

1. Antigens
2. Monoclonal Antibodies
3. gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)
4. Heat-Shock Proteins (Heat-Shock Protein)
5. Tryptases (Tryptase)
6. CD7 Antigens
7. CD13 Antigens (Alanine Aminopeptidase)
8. CD8 Antigens
9. Transferrin Receptors (Transferrin Receptor)
10. Interleukin-2 (IL2)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Splenectomy
3. Nephrectomy