Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)

A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.

Also Known As:

Networked: 7672 relevant articles (229 outcomes, 1030 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cuzzocrea, Salvatore: 24 articles (01/2021 - 01/2002)
2.	Mazzon, Emanuela: 18 articles (12/2014 - 01/2002)
3.	Yamaya, Mutsuo: 17 articles (05/2020 - 01/2002)
4.	Yu, Huang-Ping: 17 articles (01/2017 - 09/2006)
5.	Kataoka, Takao: 16 articles (06/2022 - 11/2009)
6.	Sato, Shinichi: 16 articles (03/2015 - 03/2002)
7.	Di Paola, Rosanna: 15 articles (01/2021 - 09/2003)
8.	Noma, Hidetaka: 15 articles (01/2021 - 05/2005)
9.	Chaudry, Irshad H: 14 articles (01/2017 - 08/2006)
10.	Dong, Cheng: 14 articles (01/2015 - 04/2005)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2000 - "The targeting of CD18 and ICAM-1 may prove useful in the treatment of inflammation-associated neovascularization in the cornea and elsewhere." 11/15/2023 - "In this study, we investigated inflammation-related transcripts in vascular endothelial cells (human HUEhT-1 and mouse UV2) exposed to IH by real-time RT-PCR and found that intercellular adhesion molecule-1 (ICAM-1) and endothelial cell-specific molecule-1 (ESM1) mRNAs were significantly increased. " 01/01/2021 - "In this study, we investigated how lasR mutants modulate airway epithelial membrane bound ICAM-1 (mICAM-1), a surface adhesion molecule, and determined its impact on neutrophilic inflammation in vitro and in vivo. " 10/01/2018 - "This study evaluated its effects on the expression of intercellular adhesion molecule 1 (ICAM-1) and inflammation-related mediators in IL-1β-stimulated human lung epithelial A549 cells. " 07/01/2016 - "This study suggests that exposure to bacteria and dust when handling sewage and compost may initiate an inflammation shown by an increase in serum concentration of ICAM-1. "
2.	Reperfusion Injury 02/27/2005 - "ME/PS-modified ICAM-1 antisense oligo is very effective in inhibiting the ICAM-1-dependent mechanism of graft infiltration and tissue damage involved in allograft rejection, ischemic-reperfusion injury, and CsA-induced nephrotoxicity." 06/25/2002 - "To study the effect of SOD on the expression of CD11b/CD18 and ICAM-1 after skeletal muscle ischemia / reperfusion injury in rats. " 01/01/2015 - "Use of contrast-enhanced ultrasound to monitor rabbit renal ischemia-reperfusion injury and correlations between time-intensity curve parameters and renal ICAM-1 expression." 01/01/2011 - "Ischaemia-reperfusion injury increases the expression of ICAM-1 in the lung. " 11/01/2009 - "The data suggested that ICAM-1 was already up-regulated during cold ischemia, possibly representing the mechanism of early neutrophil infiltration observed in human pancreatic ischemia/reperfusion injury."
3.	Neoplasms (Cancer) 12/15/2017 - "In mice with systemic ATC, a single administration of ICAM-1 CAR T cells mediated profound tumor killing that resulted in long-term remission and significantly improved survival. " 01/01/2023 - "Further reverse translational studies using murine syngeneic tumor models reveal that soluble ICAM-1 (sICAM-1) is a key molecule that increases the efficacy of anti-PD-1 via activation of cytotoxic T cells. " 03/17/2022 - "V937 specifically binds to and lyses cells with over-expressed ICAM-1 receptors in a range of tumor cell types and is currently in phase I and II clinical trials. " 12/01/2019 - "Mechanistic studies revealed that this progression was mediated by suppressed TNFα levels, both locally and systemically, resulting in reduced expression of tumor endothelial adhesion molecules, particularly intercellular adhesion molecule-1 (ICAM-1) and a subsequent decrease in the number of activated and effector CD8+ T cells in the tumor. " 12/19/2018 - "Several studies have shown that intercellular adhesion molecule-1 (ICAM-1) increases the invasion capability of tumor cells and placental cells. "
4.	Ischemia 03/01/2001 - "Concurrently with the up-regulated ICAM-1 and MHC expression, significantly more CD4(+) cells and macrophages infiltrated the ischemic allografts at days 2 and 3 and the ischemic isografts at day 4. Importantly, the influx of these cells after ischemia was significantly greater in allografts than in isografts. " 02/01/1998 - "The purpose of our study was to measure ICAM-1 expression in the liver and other organs after hepatic ischemia/reperfusion (I/R). " 12/01/1995 - "The results of this study indicate that early and persistent ICAM-1 expression occurs following CNS ischemia with associated leukocyte infiltration." 01/01/1993 - "The present study sought to further these observations by examining the site of potential ICAM-1 induction as a function of time of reperfusion, degree of ischemia, and viability of myocardial cells. " 01/01/2019 - "Furthermore, ischemia also markedly increased the proliferation, oxidative stress, and ICAM-1 expression in the preexisting EC in the hindlimb gracilis muscles. "
5.	Infections 04/15/1993 - "Recently, a recombinant, soluble ICAM-1 (sICAM-1) has been shown to be effective in prevention of the cytopathic effect of rhinovirus infection in vitro. " 04/01/2003 - "Without changing the CDR sequences, the humanized 1A6 scFv demonstrates over 50-fold improvement in both affinity for ICAM-1 and protection efficacy against HRV infection in vitro." 01/01/2022 - "In addition to the canonical roles of endothelial ICAM-1, this study identifies a previously unappreciated role for leukocyte ICAM-1 in infection-related TEM." 01/01/2014 - "The present study estimated the usefulness of knee skin temperature (measured by infrared thermography) and serum soluble intercellular adhesion molecule-1 (sICAM-1) in the diagnosis of post-operative knee peri-prosthetic infection. " 09/01/2004 - "In this study, we identified functions of ICAM-1 on airway epithelial cells in defense against infection with Haemophilus influenzae. "

Related Drugs and Biologics

1.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
2.	Interleukin-6 (Interleukin 6)
3.	Proteins (Proteins, Gene)
4.	Monoclonal Antibodies
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	P-Selectin
7.	E-Selectin
8.	Messenger RNA (mRNA)
9.	NF-kappa B (NF-kB)
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Resuscitation
3.	Lasers (Laser)
4.	Warm Ischemia
5.	Intravesical Administration