|1.||Migraine Disorders (Migraine)
|4.||Headache Disorders (Headache Syndromes)
|5.||Tension-Type Headache (Tension Headache)
|1.||Bendtsen, L: 14 articles (01/2010 - 06/2000)|
|2.||Jensen, R: 11 articles (06/2012 - 07/2000)|
|3.||Olesen, J: 9 articles (11/2004 - 09/2000)|
|4.||Ashina, M: 9 articles (11/2004 - 09/2000)|
|5.||Diener, H C: 7 articles (10/2011 - 08/2000)|
|6.||Evers, Stefan: 6 articles (04/2011 - 06/2004)|
|7.||Katsarava, Z: 6 articles (03/2011 - 01/2001)|
|8.||Andrasik, F: 6 articles (06/2007 - 10/2001)|
|9.||Fritsche, G: 6 articles (01/2005 - 08/2000)|
|10.||Diener, Hans-Christoph: 5 articles (09/2015 - 10/2007)|
|1.||Amitriptyline (Elavil)FDA LinkGeneric
03/01/2003 - "Amitriptyline has been shown to be moderately effective in chronic tension-type headache in several controlled studies, but the use is often hampered by side effects. "
06/01/1998 - "Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications."
06/01/1998 - "We compared the efficacy of amitriptyline (25 mg/day) in 82 nondepressed patients with either chronic or episodic tension-type headache in an open-label study. "
09/01/1996 - "Although the tricyclic antidepressant amitriptyline is extensively used in the prophylactic treatment of chronic tension-type headache, only few studies have investigated the efficacy of this treatment and the results are contradictory. "
05/25/2004 - "The tricyclic antidepressant amitriptyline is the only drug with prophylactic efficacy for chronic tension-type headache. "
|2.||Acetaminophen (Paracetamol)FDA LinkGeneric
09/01/2012 - "A Comparison of Efficacy and Safety of Non-steroidal Anti-inflammatory Drugs versus Acetaminophen in the Treatment of Episodic Tension-type Headache: A Meta-analysis of Randomized Placebo-controlled Trial Studies."
12/01/2012 - "I have a long history of tension headaches and usually get relief by taking acetaminophen. "
04/01/2003 - "These differences are clinically important, offering a shorter time to onset of relief of tension headache compared with paracetamol."
09/01/2012 - "In this meta-analysis, there was no difference between low-dose NSAIDs and acetaminophen in the efficacy of the treatment for tension type headache. "
04/01/2010 - "Efficacy of fixed combinations of acetylsalicyclic acid, acetaminophen and caffeine in the treatment of idiopathic headache: a review."
|3.||Caffeine (No Doz)FDA LinkGeneric
11/01/1994 - "This paper discusses alternative statistical models for the analysis of six crossover studies to determine whether better relief of tension headache occurs from treatment with an analgesic plus caffeine (C) than with the analgesic alone (A) or with placebo (P). "
11/01/1994 - "Evaluation of alternative statistical models for crossover studies to demonstrate caffeine adjuvancy in the treatment of tension headache."
11/01/1994 - "Caffeine as an analgesic adjuvant in tension headache."
10/01/2001 - "The study was designed to also verify the analgesic efficacy of caffeine and further assess the role of tension-type headache as a model for the study of pain."
01/01/2001 - "Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?"
|4.||Botulinum Toxins (Botulinum Toxin)IBA
08/01/2004 - "Botulinum toxin was not proven effective in treatment of chronic tension-type headache. "
02/01/2009 - "Botulinum toxin: could it be an effective treatment for chronic tension-type headache?"
08/01/2004 - "We conducted a randomized, placebo-controlled clinical trial to prove efficacy of botulinum toxin in chronic tension-type headache. "
03/01/2013 - "There have been several other randomized trials looking at treatment of chronic tension type headaches with botulinum toxin A therapy. "
12/01/2007 - "To date, the majority of double-blind and placebo-controlled studies do not suggest that botulinum toxin A is efficacious in the treatment of chronic idiopathic headache disorders. "
|5.||Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
10/01/2014 - "In tension-type headache, aspirin acts in a dose-dependent fashion. "
12/30/2011 - "Acetylsalicylic acid inhibits α,β-meATP-induced facilitation of neck muscle nociception in mice--implications for acute treatment of tension-type headache."
02/01/2007 - "Aspirin and tension-type headache."
01/01/2012 - "Aspirin is first-line treatment for migraine and episodic tension-type headache regardless of headache intensity."
01/01/2012 - "(1) To establish whether pre-treatment headache intensity in migraine or episodic tension-type headache (ETTH) predicts success or failure of treatment with aspirin; and (2) to reflect, accordingly, on the place of aspirin in the management of these disorders. "
|6.||Ibuprofen (Motrin)FDA LinkGeneric
07/01/2000 - "Solubilized ibuprofen: evaluation of onset, relief, and safety of a novel formulation in the treatment of episodic tension-type headache."
02/01/2007 - "Moreover, the study suggests that daily intake of ibuprofen worsens headache already after few weeks in chronic tension-type headache."
12/01/2006 - "Though all non-narcotic analgesics have equivalent efficacy against tension-type headache, ibuprofen's generally favorable side-effect profile makes it a reasonable first choice."
01/01/2001 - "Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?"
01/01/2003 - "Of 684 subjects randomised, 620 used the study drugs for an episode of tension headache occurring within one month after enrolment: diclofenac-K 12.5mg (n=160), diclofenac-K 25mg (n=156), ibuprofen 400mg (n=151) and placebo (n=153). "
|7.||Serotonin (5 Hydroxytryptamine)IBA
06/01/2009 - "The aim of the research is to study the characteristics of ache and the level of serotonin in blood serum in tension-type headache. "
02/01/2003 - "The findings of the present study show that there is a decrease in the number of binding sites of 5-HT2A receptors in some patients with tension-type headache, suggesting postsynaptic serotonergic dysfunction and the involvement of serotonin in that group."
12/01/1997 - "The aim of the present study was to investigate the peripheral serotonin (5HT) metabolism in patients with chronic tension-type headache. "
06/01/1994 - "We performed a controlled study of 5-hydroxytryptamine (5HT) in platelet poor plasma obtained from 13 female patients during and between episodes of tension-type headache. "
12/01/1987 - "The study implicates the role of serotonin in tension headache."
|8.||Antidepressive Agents (Antidepressants)IBA
10/01/2007 - "The purpose of the present study was to assess a group of patients with chronic tension-type headache (CTTH) and control subjects using the personality questionnaire proposed by Cloninger and to determine possible changes in the Temperament and Character Inventory (TCI) patterns of CTTH patients after therapy with serotonergic antidepressants. "
05/24/2008 - "[Antidepressant drugs in the treatment of tension-type headache]."
10/01/2011 - "The focus of this review is on the efficacy of antidepressants as preventive treatments for migraine and chronic tension-type headache (TTH). "
10/01/1990 - "Antidepressants are the primary modality for treatment of tension type headaches, although they are also used for migraine prophylaxis. "
09/01/1986 - "Five studies of either migraine or chronic tension headache all demonstrated superior efficacy of antidepressants versus placebo, while those of back and arthritic pain yielded mixed results. "
|9.||tizanidine (Zanaflex)FDA LinkGeneric
11/01/1992 - "The results of the present trial suggest that tizanidine is effective in the treatment of chronic tension-type headache in women."
09/01/2000 - "The efficacy of the modified-release formulation of tizanidine (Sirdalud) was compared with placebo in a randomized, double-blind, parallel-group study of 138 women and 47 men, aged 18 to 79 years, with a history of chronic tension-type headache (IHS categories 2.2 and 2.3). "
09/01/2000 - "The modified-release formulation of tizanidine in doses up to 12 mg taken in the evening is not superior to placebo in the treatment of chronic tension-type headache. "
09/01/2000 - "Modified-release formulation of tizanidine in chronic tension-type headache."
01/01/1997 - "For the first time sirdalud was used in the treatment of 32 patients with chronic form of tension-type headache. "
|10.||Naproxen (Naprosyn)FDA LinkGeneric
11/01/2002 - "The objective of this study was to evaluate and compare the efficacy and safety of single doses of acetaminophen (paracetamol) 1000 mg and naproxen 375 mg vs. placebo over a six-hour period in the treatment of tension-type headache. "
11/01/2002 - "In summary, the results of this well-controlled, double-blind study demonstrate that over-the-counter acetaminophen 1000 mg and prescription naproxen 375 mg are effective and well tolerated in the treatment of tough (moderate-to-severe) tension-type headache."
11/01/2002 - "Efficacy and safety of acetaminophen and naproxen in the treatment of tension-type headache. "
02/01/2013 - "Naproxen and hydroxyzine are commonly used oral rescue therapies for older adults who have migraine or tension headaches. "
01/01/1992 - "Experimental tension headache in humans: a double blind comparison of the analgesic effect of dipyrone, naproxen plus paracetamol or placebo."
|1.||Psychology Biofeedback (Biofeedback)
02/01/1981 - "Following remission, that took place early in the experiment (as a consequence of recording incidence), nine subjects from a sample of 40 patients suffering from chronic tension headaches were randomly assigned to one of two treatment conditions: five to a 'frontalis EMG-biofeedback' group, and four to a control condition designated 'high expectations of cure'. "
01/01/1983 - "On the other hand, there is evidence that EMG biofeedback training is effective for treating tension headaches, but the EMG biofeedback training is not more effective than less complex and less expensive relaxation training. "
08/01/1990 - "The purpose of this study is to assess if EMG biofeedback training with progressive muscle relaxation training is effective in reducing the EMG level in patients with tension headaches. "
02/01/2001 - "This study explored the efficacy of a thermal biofeedback treatment package as an intervention with children with tension-type headaches. "
02/01/2001 - "The efficacy of the thermal biofeedback treatment package is supported as an alternative treatment for children suffering from tension-type headaches."
|2.||Musculoskeletal Manipulations (Manipulative Therapy)
03/01/1995 - "The results of this study show that spinal manipulative therapy is an effective treatment for tension headaches. "
03/01/2014 - "The purpose of this study was to evaluate the efficacy of manipulative and manual therapy treatments with regard to pain perception and neck mobility in patients with tension-type headache. "
12/01/2015 - "All randomized controlled trials comparing any manual therapy vs. medication care for treating tension type headache adults were included. "
12/01/2015 - "Multimodal manual therapy vs. pharmacological care for management of tension type headache: A meta-analysis of randomized trials."
10/01/2014 - "This study researches the effectiveness of two manual therapy treatments focused on the suboccipital region for tension-type headache. "
|3.||Transcutaneous Electric Nerve Stimulation (TENS)
03/01/1990 - "For tension headaches, transcutaneous electrical nerve stimulation (TENS) has produced good improvement in recent investigations in about 3/4 of cases; full remissions were possible in most cases. "
01/01/2008 - "The effect of TENS on selected symptoms in the management of patients with chronic tension type headache: a preliminary study."
01/01/2008 - "This study was aimed at investigating the efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) on Pain, Functional Disability and Cervical Range of Motion in patients with Chronic Tension Type Headache (CTTH). "
07/01/1989 - "Cranial electrotherapy stimulation is distinct from TENS, and is safe and often effective in ameliorating the pain intensity of tension headaches. "
04/01/2015 - "The objective of this article is to determine whether cutaneous allodynia (CA) influences the response to treatment with occipital transcutaneous electrical stimulation (OTES) in chronic migraine (CM) and chronic tension-type headache (CTTH). "
|4.||Drug Therapy (Chemotherapy)
01/01/2010 - "These aimed 'to improve the quality of controlled clinical trials in tension-type headache', because 'good quality controlled trials are the only way to convincingly demonstrate the efficacy of a drug, and form the basis for international agreement on drug therapy'. "
10/01/2002 - "As a result, there are few well-designed studies on the pharmacotherapy of tension-type headaches. "
06/01/2009 - "Pharmacotherapy of tension-type headache (TTH)."
12/01/2003 - "New developments in the pharmacotherapy of tension-type headaches."
12/01/2003 - "Current and potential future drug therapies for tension-type headache."
03/01/2005 - "This study suggests that laser acupuncture may be an effective treatment for chronic tension-type headache, but the results should be confirmed in larger and more rigorous trials."
10/01/2006 - "In the present study, we examined clinical and laser-evoked potentials (LEP) features in a group of chronic tension-type headache (CTTH) patients, in order to perform a topographic analysis of Laser evoked potentials (LEPs) and a correlation with clinical features. "
03/01/2005 - "The effects of laser acupuncture on chronic tension headache--a randomised controlled trial."
06/01/2003 - "The aim of the study was to evaluate the laser-induced suppression periods of the temporalis muscle in patients with tension-type headache, compared with the pattern of temporalis activity suppression induced by electrical stimulation. "
10/01/2006 - "Topographic analysis of laser evoked potentials in chronic tension-type headache: correlations with clinical features."