Multiple Chemical Sensitivity (Idiopathic Environmental Intolerance)

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56 relevant articles (0 outcomes, 5 trials/studies) found for this Disease

Description: An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)

Also Known As:

Idiopathic Environmental Intolerance; Chemical Sensitivities, Multiple; Chemical Sensitivity, Multiple; Multiple Chemical Sensitivities; Multiple Chemical Sensitivity Syndrome; Sensitivities, Multiple Chemical; Sensitivity, Multiple Chemical; Environmental Intolerance, Idiopathic; Environmental Intolerances, Idiopathic; Intolerance, Idiopathic Environmental; Intolerances, Idiopathic Environmental; Idiopathic Environmental Intolerances

Disease Context: Research Results

Immune System Diseases: 1237

Hypersensitivity: 36030

Environmental Illness: 12

Multiple Chemical Sensitivity: 56

Disorders of Environmental Origin

Environmental Illness: 12

Multiple Chemical Sensitivity: 56

Related Diseases

1.	Syndrome
2.	Burkitt Lymphoma (B-ALL)
3.	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)
4.	Fibromyalgia (Fibrositis)
5.	Post-Traumatic Stress Disorders (PTSD)

Experts

1.	Brown, Molly M: 2 articles (01/2007 - 01/2007)
2.	Jason, Leonard A: 2 articles (01/2007 - 01/2007)
3.	Marshall, Lynn: 2 articles (10/2004 - 09/2004)
4.	Jazmaji, Vartouhi: 2 articles (10/2004 - 09/2004)
5.	Riley, Nicole: 2 articles (10/2004 - 09/2004)
6.	Pall, Martin L: 2 articles (09/2003 - 09/2002)
7.	Pall, M L: 2 articles (08/2001 - 03/2001)
8.	Poonai, N: 2 articles (05/2001 - 02/2000)
9.	Tyndale, Rachel F: 1 article (10/2004)
10.	Baines, Cornelia: 1 article (10/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Chemical Sensitivity:

1.	SolventsIBA 09/01/2002 - "Multiple chemical sensitivity (MCS) is a condition where previous exposure to hydrophobic organic solvents or pesticides appears to render people hypersensitive to a wide range of chemicals, including organic solvents" 01/01/1999 - "Recently, the solvents are quoted among possible causes of the abnormal condition referred to as multiple chemical sensitivity (MCS), and which is characterized by a psychosomatic over-reactivity to a variety of chemicals present in food or ambient air" 11/01/1995 - "Three occupational exposures to solvents, poor indoor-air quality, and remodeling were associated with onset of Multiple Chemical Sensitivities in 63% of the subjects" 03/01/1995 - "The persistent, disabling neuropsychological symptoms reported by these multiple chemical sensitivity groups are strikingly similar to those reported among individuals exposed occupationally to pesticides and solvents" 07/01/1992 - "Acquired intolerance to solvents following pesticide/solvent exposure in a building: a new group of workers at risk for multiple chemical sensitivities?" Order ALL the reference details at left...
2.	Formaldehyde (Formol)IBA 07/17/1996 - "Proposed animal neurosensitization model for multiple chemical sensitivity in studies with formalin." 09/01/2004 - "Medical students during their dissection course are exposed to formaldehyde, whose exposure is recently considered to be one of the causes of multiple chemical sensitivity" 06/01/2003 - "Multiple chemical sensitivity (MCS) is characterized by various somatic symptoms which cannot be explained organically and by sensitivity to extremely low concentrations of chemicals including formaldehyde" 06/01/2003 - "Formaldehyde exposure and multiple chemical sensitivity]" 03/01/2001 - "Repeated formaldehyde effects in an animal model for multiple chemical sensitivity." Order ALL the reference details at left...
3.	Gasoline (Diesel Fuel)IBA 07/01/1999 - "Re: Davidoff et al. Development of multiple chemical sensitivities in laborers after acute gasoline fume exposure in an underground tunnelling operation." 05/01/1998 - "Development of multiple chemical sensitivities in laborers after acute gasoline fume exposure in an underground tunneling operation." 05/01/1998 - "The cohort was unique in several ways: (a) contact with gasoline was made by the workers at a time when no one had complained of multiple chemical sensitivities syndrome; (b) all were males of low socioeconomic status; (c) the exposure was well documented; (d) the cohort could be considered "naive" because, at the time of the study, the men were not members of support groups and were not being seen by clinical ecologists, and they were not labeled, either by self or others, as having multiple chemical sensitivities syndrome or any related diagnosis; and (e) at the time of interview, all workers we contacted appeared to be either gainfully employed or laid off temporarily and seeking gainful employment" 05/01/1998 - "The workers were chronically overexposed to gasoline fumes, after which approximately one-fourth (26.7%) of our random sample of relatively naive, low-socioeconomic-status male laborers-although neither disabled nor generally litigious-reported the new onset of chemical hypersensitivities and other characteristics that fit conservative criteria for multiple chemical sensitivities syndrome." 03/01/2001 - "Sensitive subgroups include subjects who met Cullen's 1987 criteria for multiple chemical sensitivity (MCS), Gulf War veterans with chronic fatigue syndrome and chemical sensitivity (CFS/CS), and subjects with specific self-reported sensitivities to methyl terbutyl ether (MTBE) in gasoline (MTBE-sensitive)" Order ALL the reference details at left...
4.	Caffeine (No Doz)FDA LinkGeneric 03/01/1997 - "The literature on human caffeine discrimination provides a rigorous methodology that can address reports that patients who suffer multiple chemical sensitivity (MCS) are sensitive to usually well-tolerated chemical doses; the studies require patients to discriminate caffeine from placebo under double-blind conditions" 04/01/1999 - "Using the Environmental Exposure and Sensitivity Inventory (EESI), a standardized instrument for measuring chemical sensitivity, we obtained and compared ratings of symptoms, chemical (inhalant) intolerances, other intolerances (e.g., drugs, caffeine, alcohol, skin contactants), lifeimpact, and masking (ongoing exposures) in five populations: multiple chemical sensitivity (MCS) patients who did (n = 96) or did not (n = 90) attribute onset of their illness to a specific exposure event, patients with implanted devices (n = 87), Gulf War veterans (n = 72), and controls (n = 76)" 03/01/1997 - "Human drug discrimination and multiple chemical sensitivity: caffeine exposure as an experimental model." 07/17/1996 - "Multiple Chemical Sensitivity (MCS) is a clinical phenomenon in which individuals, after acute or intermittent exposure to one or more chemicals, commonly organophosphate pesticides (OPs), become overly sensitive to a wide variety of chemically-unrelated compounds, which can include ethanol, caffeine and other psychotropic drugs" Order ALL the reference details at left...
5.	tyramine-deoxysorbitolIBA 07/01/1994 - "The present paper summarizes the proposed time-dependent sensitization (TDS) and partial limbic kindling model for illness from low-level chemicals; reviews and critiques prior studies on CNS aspects of multiple chemical sensitivity (MCS); and outlines possible experimental approaches to future studies" 03/01/1997 - "The Working Group on Sensitization and Kindling identified two primary goals for a research approach to this problem: to perform controlled experiments to determine whether or not sensitization to low-level chemical exposures occurs in multiple chemical sensitivity (MCS) patients; and to use animal preparations for kindling and TDS as nonhomologous models for the initiation and elicitation of MCS." 07/01/1994 - "Several features of TDS parallel those of multiple chemical sensitivity (MCS) in humans, and these similarities have led to the hypothesis that MCS may be explained in part by a similar sensitization process that occurs in rodents" Order ALL the reference details at left...
6.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2007 - "Short-term stressors, capable of increasing nitric oxide levels, act to initiate cases of illnesses including chronic fatigue syndrome, multiple chemical sensitivity, fibromyalgia and posttraumatic stress disorder" 03/01/2001 - "Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder." 08/01/2001 - "Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite." 09/01/2003 - "The elevated nitric oxide/peroxynitrite and the neural sensitization theories of multiple chemical sensitivity (MCS) are extended here to propose a central mechanism for the exquisite sensitivity to organic solvents apparently induced by previous chemical exposure in MCS" 09/01/2003 - "Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism." Order ALL the reference details at left...
7.	Peroxynitrous Acid (Peroxynitrite)IBA 03/01/2001 - "Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder." 08/01/2001 - "Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite." 09/01/2003 - "The elevated nitric oxide/peroxynitrite and the neural sensitization theories of multiple chemical sensitivity (MCS) are extended here to propose a central mechanism for the exquisite sensitivity to organic solvents apparently induced by previous chemical exposure in MCS" 09/01/2003 - "Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism." 09/01/2002 - "NMDA sensitization and stimulation by peroxynitrite, nitric oxide, and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity." Order ALL the reference details at left...
8.	XenobioticsIBA 01/01/2008 - "One postulated mechanism underlying multiple chemical sensitivity (MCS) is based on increased metabolism of xenobiotics" 02/15/2000 - "Among the sanitary effects of environmental chemicals, 3 examples illustrate the complexity of the issues to be solved: 1. endocrine disrupters, xenobiotics which interfere with hormonal systems, could increase the risk of reproductive and developmental disturbances and explain the rising incidence of hormone-dependent cancers; 2. multiple chemical sensitivity due to odorous chemicals has severe social consequences and warrants further research; 3. the reappearance of well-known poisoning cases and the emergent new toxic diseases due to substitutive products for solvents, cooling agents and spray propellants banned for ecological purpose, demonstrate the need for surveillance programmes of industrial and household products." Order ALL the reference details at left...
9.	TolueneIBA 10/01/2003 - "Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure." 03/01/2005 - "We studied the change in the hypothalamo-pituitary-adrenal gland (HPA) axis upon adding prior toluene inhalation to our previous formaldehyde inhalation experiments to determine whether short term exposure to relatively high levels of toluene triggers multiple chemical sensitivity (MCS)" Order ALL the reference details at left...
10.	SiliconesIBA 06/01/1999 - "These syndromes include multiple chemical sensitivity, the sick building syndrome, repetition stress injury, the side effects of silicone breast implants, the Gulf War syndrome, chronic whiplash, the chronic fatigue syndrome, the irritable bowel syndrome, and fibromyalgia" 08/01/2003 - "Overlapping symptom complexes suggest that chronic fatigue syndrome, Gulf war syndrome, premenstrual syndrome, post traumatic stress disorder, breast implant silicone sensitivity syndrome, bipolar affective disorder, systemic candidiasis, myofascial pain syndrome, and idiopathic environmental intolerance are similar enough to fibromyalgia to merit investigation for possible thyroid resistance" Order ALL the reference details at left...

Therapies and Procedures

1.	Breast Implants (Breast Implant) 06/01/1999 - "These syndromes include multiple chemical sensitivity, the sick building syndrome, repetition stress injury, the side effects of silicone breast implants, the Gulf War syndrome, chronic whiplash, the chronic fatigue syndrome, the irritable bowel syndrome, and fibromyalgia" 08/01/2003 - "Overlapping symptom complexes suggest that chronic fatigue syndrome, Gulf war syndrome, premenstrual syndrome, post traumatic stress disorder, breast implant silicone sensitivity syndrome, bipolar affective disorder, systemic candidiasis, myofascial pain syndrome, and idiopathic environmental intolerance are similar enough to fibromyalgia to merit investigation for possible thyroid resistance" Order ALL the reference details at left...
2.	Complementary Therapies (Alternative Medicine) 09/01/2003 - "Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity." Order ALL the reference details at left...

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