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Oncogene Proteins v-erbA

Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
Also Known As:
Oncogene Products v-erbA; Oncogene Products v erbA; Oncogene Proteins v erbA; v erbA Proteins; erbA Oncogene Proteins; v-erbA Proteins
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