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Systemic Inflammatory Response Syndrome (Sepsis Syndrome)

A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
Also Known As:
Sepsis Syndrome; Sepsis Syndromes; Syndrome, Sepsis; Syndromes, Sepsis; Inflammatory Response Syndrome, Systemic
Networked: 1601 relevant articles (63 outcomes, 184 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Sepsis (Septicemia)
2. Acute Lung Injury
3. Critical Illness (Critically Ill)
4. Septic Shock (Toxic Shock Syndrome)
5. Multiple Organ Failure (MODS)

Experts

1. Gando, Satoshi: 14 articles (01/2014 - 08/2002)
2. Westphal, Martin: 10 articles (02/2011 - 02/2005)
3. Van Aken, Hugo: 8 articles (06/2015 - 11/2006)
4. Traber, Daniel L: 8 articles (02/2011 - 11/2003)
5. Hayakawa, Mineji: 8 articles (10/2009 - 08/2002)
6. Manzanares, William: 7 articles (02/2015 - 05/2009)
7. Aikawa, Naoki: 7 articles (01/2014 - 01/2004)
8. Bone, Hans-Georg: 7 articles (11/2008 - 11/2006)
9. Lange, Matthias: 7 articles (11/2008 - 11/2006)
10. Ogura, Hiroshi: 6 articles (07/2015 - 02/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Systemic Inflammatory Response Syndrome:
1. ONO 5046 (sivelestat)IBA
2. SeleniumIBA
3. Leukocyte Elastase (Neutrophil Elastase)IBA
4. SodiumIBA
5. CytokinesIBA
6. procalcitoninIBA
7. Interleukin-6 (Interleukin 6)IBA
8. nebacumabIBA
9. Intravenous Immunoglobulins (IVIG)FDA Link
10. EnzymesIBA

Therapies and Procedures

1. Artificial Respiration (Mechanical Ventilation)
2. Critical Care
3. Cardiopulmonary Bypass (Heart-Lung Bypass)
4. Transplants (Transplant)
5. Coronary Artery Bypass (Coronary Artery Bypass Surgery)