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Bethanechol (Duvoid)

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A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms.

Also Known As:

Duvoid; Myotonachol; Bethanechol Chloride; Bethanecol; Glenwood Brand of Bethanechol Chloride; Hamilton Brand of Bethanechol Chloride; Myo Hermes; Myocholine; Myotonine; Organon Brand of Bethanechol Chloride; PMS-Bethanechol Chloride; Pharmascience Brand of Bethanechol Chloride; Roberts Brand of Bethanechol Chloride; Urocarb; Chloride, Bethanechol; Hermes, Myo; PMS Bethanechol Chloride; PMSBethanechol Chloride; 1-Propanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-

Networked: 280 relevant articles (21 outcomes, 41 trials/studies) for this Drug, Comments

Relationship Network

Drug Context: Research Results

Organic Chemicals: 41
- Amines: 1208
  - Quaternary Ammonium Compounds: 928
    - Trimethyl Ammonium Compounds
      - Bethanechol Compounds: 26
        Bethanechol: 280
- Onium Compounds
  - Quaternary Ammonium Compounds: 928
    - Bethanechol Compounds: 26
      - Bethanechol: 280

Experts

1.	Vilegas, Wagner: 3 articles (03/2006 - 09/2002)
2.	Toma, Walber: 3 articles (12/2004 - 09/2002)
3.	Lemos, Marivane: 2 articles (02/2010 - 07/2009)
4.	Gandolfi, Renan Becker: 2 articles (02/2010 - 07/2009)
5.	de Andrade, Sérgio Faloni: 2 articles (02/2010 - 07/2009)
6.	Cechinel Filho, Valdir: 2 articles (02/2010 - 07/2009)
7.	McKay, Derek M: 2 articles (04/2009 - 11/2006)
8.	Hirota, Christina L: 2 articles (04/2009 - 11/2006)
9.	Silverman, Sol: 2 articles (07/2006 - 02/2004)
10.	Gorsky, Meir: 2 articles (07/2006 - 02/2004)

Related Diseases

1.	Malacoplakia 11/01/1979 - "We report on 3 patients with vesical malacoplakia who were treated successfully with bethanechol chloride." 10/01/1980 - "Re: malacoplakia of the bladder: efficacy of bethanechol chloride therapy." 04/01/1980 - "Re: malacoplakia of the bladder: efficacy of bethanechol chloride therapy." 11/01/1979 - "Malacoplakia of the bladder: efficacy of bethanechol chloride therapy." 09/01/1986 - "A second patient is described with the syndrome of hypogammaglobulinaemia and malakoplakia; he too responded dramatically to bethanechol treatment and remains well on it." Order ALL the reference details at left...
2.	Gastroesophageal Reflux (GERD) 08/01/1993 - "The similar action of the two H2-antagonists appears to suggest that their effect on salivation is connected probably with the cholinergic activity and it is concluded that the combination of bethanechol with these blockers may improve the esophageal clearance, an action that may be beneficial in the treatment of the gastroesophageal reflux disease." 12/01/1985 - "These results fail to show that bethanechol is more effective than antiacids in controlling gastroesophageal reflux; moreover, bethanechol is more difficult to administer and offers a higher rate of undesired side effects." 03/01/1975 - "Recently cholinergic stimulation of the lower esophageal sphincter (LES) with bethanechol has been shown to be effective in the treatment of chronic gastroesophageal reflux. " 12/01/1985 - "To compare the efficacy of bethanechol in the treatment of gastroesophageal reflux with that of antiacids, a prospective, cross-over study was undertaken, in which 20 affected infants and children were randomized into two groups on 6-week alternate bethanechol and antiacids oral medication. " 07/01/1986 - "Thus, this study demonstrates a failure of the acute administration of bethanechol to improve postprandial gastroesophageal reflux and raises the issue of whether the widespread use of bethanechol to treat reflux in children is appropriate." Order ALL the reference details at left...
3.	Esophagitis 06/01/1982 - "These results fail to show that the addition of bethanechol to an intensive antacid regimen is more effective than the antacid regimen alone in the treatment of erosive esophagitis and that patients with esophagitis and normal lower esophageal sphincter pressures respond more favorably to medical treatment." 06/01/1982 - "Double-blind controlled trial of bethanechol and antacid versus placebo and antacid in the treatment of erosive esophagitis." 06/01/1982 - "To determine the value of bethanechol in the treatment of erosive esophagitis, a double-blind study was undertaken in which 28 patients were randomized to either bethanechol and antacid, or placebo and antacid. " 07/01/1976 - "In contrast, the sphincter response to bethanechol during esophagitis was not different from the preperfusion response and remained unchanged after resolution of the esophagitis. " 03/01/1975 - "Since chronic reflux and esophagitis also occur in patients with vagotomy and antrectomy, we studied the effect of bethanechol on sphincter pressure in 10 patients who had had vagotomy and antrectomy. " Order ALL the reference details at left...
4.	Vomiting 06/15/1991 - "Treatment with metoclopramide hydrochloride and bethanechol chloride resulted in improved attitude, appetite, Schirmer tear test response, and decrease in frequency of vomiting within 24 hours. " 09/01/2006 - "The authors describe complete remission of recurrent postprandial discomfort, nausea, and vomiting within 1 week of starting mirtazapine in a gastroparetic patient who had failed to respond, in 7 months, to conventional prokinetics (erythromycin, metoclopramide, domperidone, perphenazine, itopride, bethanechol, and/or tegaserod) and pyloric injection of botulinum toxin. " Order ALL the reference details at left...
5.	Peptic Esophagitis (Reflux Esophagitis) 12/01/1980 - "Our study indicates that bethanechol is an effective drug offering advantages over conventional antacid therapy in the treatment of reflux esophagitis." 12/01/1980 - "We ascertained the effectiveness of oral bethanechol on symptoms and endoscopic evaluation of reflux esophagitis in a double-blind controlled study. " 12/01/1980 - "Reflux esophagitis: effect of oral bethanechol on symptoms and endoscopic findings." 12/01/1981 - "Cimetidine and bethanechol along with the conventional medical regimen for reflux esophagitis may also be helpful in healing the inflamed mucosa. " 06/01/1983 - "Our study indicates that metoclopramide, both parenterally and orally, increased the rate of gastric emptying in those reflux esophagitis patients in whom it was delayed, while bethanechol did not improve the degree of gastric retention in the same patients. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
2.	Metoclopramide (Reglan)
3.	Ascorbic Acid (Vitamin C)
4.	Pilocarpine (Ocusert)
5.	Cimetidine (Biomet)
6.	Domperidone (Domperidon)
7.	Erythromycin (Erycette)
8.	Diltiazem (Cardizem)
9.	Vitamin A (Retinol)
10.	Perphenazine (Trilafon)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Radiotherapy
3.	Cystectomy
4.	Gastrectomy
5.	Oral Administration

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