Bethanechol (Duvoid)

A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.

Also Known As:

Networked: 361 relevant articles (27 outcomes, 54 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Cechinel Filho, Valdir: 3 articles (11/2012 - 07/2009)
2.	de Andrade, Sérgio Faloni: 3 articles (11/2012 - 07/2009)
3.	Vilegas, Wagner: 3 articles (03/2006 - 09/2002)
4.	Toma, Walber: 3 articles (12/2004 - 09/2002)
5.	Jaguar, Graziella Chagas: 2 articles (10/2022 - 05/2015)
6.	Jensen, Siri Beier: 2 articles (01/2021 - 11/2013)
7.	Raufman, Jean-Pierre: 2 articles (02/2018 - 04/2013)
8.	Carvalho, André Lopes: 2 articles (05/2015 - 02/2007)
9.	Gandolfi, Renan Becker: 2 articles (02/2010 - 07/2009)
10.	Lemos, Marivane: 2 articles (02/2010 - 07/2009)

Related Diseases

1.	Malacoplakia 11/01/1979 - "We report on 3 patients with vesical malacoplakia who were treated successfully with bethanechol chloride." 09/01/1986 - "A second patient is described with the syndrome of hypogammaglobulinaemia and malakoplakia; he too responded dramatically to bethanechol treatment and remains well on it." 09/01/1986 - "Hypogammaglobulinaemia and malakoplakia: response to bethanechol." 07/01/1984 - "[Colonic malacoplakia: use of bethanechol]." 10/01/1980 - "Re: malacoplakia of the bladder: efficacy of bethanechol chloride therapy."
2.	Xerostomia 01/01/2017 - "Some studies have shown evidence that the prophylactic use of bethanechol chloride (BC) may be useful in preventing the incidence and/or severity of xerostomia (XT). " 10/01/2022 - "Interestingly, Bethanechol patients who received 131I dose > 125mCi, showed better xerostomia indices when compared to the Placebo with same dose. " 01/01/2023 - "The present study suggests that bethanechol chloride therapy may be effective in patients with xerostomia and hyposalivation." 06/01/1994 - "The effects of bethanechol in the treatment of dry mouth were assessed in patients with xerostomia after radiation therapy to the head and neck. " 06/01/1994 - "A clinical trial of bethanechol in patients with xerostomia after radiation therapy. "
3.	Gastroesophageal Reflux (GERD) 12/01/1985 - "These results fail to show that bethanechol is more effective than antiacids in controlling gastroesophageal reflux; moreover, bethanechol is more difficult to administer and offers a higher rate of undesired side effects." 12/01/1985 - "To compare the efficacy of bethanechol in the treatment of gastroesophageal reflux with that of antiacids, a prospective, cross-over study was undertaken, in which 20 affected infants and children were randomized into two groups on 6-week alternate bethanechol and antiacids oral medication. " 07/01/1986 - "Thus, this study demonstrates a failure of the acute administration of bethanechol to improve postprandial gastroesophageal reflux and raises the issue of whether the widespread use of bethanechol to treat reflux in children is appropriate." 07/01/1986 - "Bethanechol for pediatric gastroesophageal reflux: a prospective, blind, controlled study." 07/01/1986 - "To investigate the effect of bethanechol on postprandial gastroesophageal reflux in children, and the relationship between its effect on the lower esophageal sphincter pressure and its effect on reflux, we studied 31 consecutive children with pathologic reflux, using manometry and pH probe, both before and after administration of bethanechol. "
4.	Esophagitis 07/01/1976 - "In contrast, the sphincter response to bethanechol during esophagitis was not different from the preperfusion response and remained unchanged after resolution of the esophagitis. " 03/01/1975 - "Since chronic reflux and esophagitis also occur in patients with vagotomy and antrectomy, we studied the effect of bethanechol on sphincter pressure in 10 patients who had had vagotomy and antrectomy. " 03/01/1977 - "In this study we determined the acute effect of bethanechol (5 mg SC) on gastroesophageal reflux (GER) and lower esophageal sphincter pressure (LESP) in 27 patients with symptomatic esophagitis. " 01/01/1986 - "Only bethanechol and the histamine H2 antagonists have been conclusively shown to improve esophagitis significantly. " 06/01/1982 - "These results fail to show that the addition of bethanechol to an intensive antacid regimen is more effective than the antacid regimen alone in the treatment of erosive esophagitis and that patients with esophagitis and normal lower esophageal sphincter pressures respond more favorably to medical treatment."
5.	Urinary Retention 08/01/1950 - "The use of urecholine in the management of chronic urinary retention." 08/01/2019 - "Bethanechol continues to be prescribed in elderly women primarily for detrusor atony, urinary retention, or incomplete bladder emptying." 10/01/2003 - "Urinary retention was treated with bethanechol and subsided within a few days. " 10/01/1989 - "Bethanechol, in a dose of 10 mg subcutaneously, significantly lowered the incidence of postoperative urinary catheterization and should be considered as initial treatment of postoperative urinary retention following anorectal surgery." 01/01/1987 - "Urecholine prophylaxis for urinary retention in anorectal surgery."

Related Drugs and Biologics

1.	Ascorbic Acid (Vitamin C)
2.	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)
3.	Cholinergic Agents (Cholinergics)
4.	Metoclopramide (Reglan)
5.	Pilocarpine (Ocusert)
6.	Antacids
7.	Muscarinic Agonists
8.	Cimetidine (Biomet)
9.	Glucose (Dextrose)
10.	Phenoxybenzamine

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Aftercare (After-Treatment)
4.	Hysterectomy
5.	Cystectomy