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erbB-2 Receptor (Receptor, erbB 2)

A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members.
Also Known As:
Receptor, erbB 2; Receptor, erbB-2; Oncogene Protein HER-2; Proto-Oncogene Proteins c-erbB-2; Receptors, erbB-2; p185(c-neu); HER 2 Proto Oncogene Protein; Oncogene Protein HER 2; Proto Oncogene Protein HER 2; Proto Oncogene Proteins c erbB 2; Proto-Oncogene Protein, HER-2; Proto-Oncogene Protein, erbB-2; Proto-Oncogene Protein, neu; Receptors, erbB 2; c erbB 2 Protein; erbB 2 Proto Oncogene Protein; erbB 2 Receptor Protein Tyrosine Kinase; erbB-2 Receptors; neu Proto Oncogene Protein; HER-2 Proto-Oncogene Protein; Proto-Oncogene Protein HER-2; Proto-Oncogene Protein p185(neu); Receptor, neu; c-erbB-2 Protein; erbB-2 Proto-Oncogene Protein; erbB-2 Receptor Protein-Tyrosine Kinase; neu Proto-Oncogene Protein; neu Receptor
Networked: 459 relevant articles (7 outcomes, 58 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kerin, Michael J: 4 articles (01/2014 - 01/2009)
2. Miller, Nicola: 3 articles (01/2014 - 01/2009)
3. Lowery, Aoife J: 3 articles (06/2012 - 01/2009)
4. Ooi, Akishi: 3 articles (07/2002 - 01/2002)
5. Tsuda, H: 3 articles (01/2001 - 01/2000)
6. Fukutomi, T: 3 articles (01/2001 - 01/2000)
7. Nanni, Patrizia: 2 articles (01/2014 - 11/2010)
8. Cavallo, Federica: 2 articles (01/2014 - 06/2006)
9. Ball, Graham: 2 articles (01/2014 - 01/2009)
10. Errihani, Hassan: 2 articles (01/2014 - 01/2011)

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Breast Neoplasms (Breast Cancer)
3. Neoplasms (Cancer)
4. Adenocarcinoma
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. Epidermal Growth Factor Receptor (EGF Receptor)
2. trastuzumab (Herceptin)
3. Paraffin
4. DNA (Deoxyribonucleic Acid)
5. Protein-Tyrosine Kinases (Tyrosine Kinase)
6. Formaldehyde (Formol)
7. Estrogens (Estrogen)
8. Progesterone Receptors (Progesterone Receptor)
9. Hormones
10. Progesterone

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Neoadjuvant Therapy
4. Adjuvant Chemotherapy
5. Gastrectomy