Filoviridae Infections

Infections with viruses of the family FILOVIRIDAE. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.

Also Known As:

Networked: 97 relevant articles (8 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Vesicular Stomatitis
3.	Virus Diseases (Viral Diseases)
4.	Poliomyelitis (Polio)
5.	Marburg Virus Disease

Experts

1.	Bavari, Sina: 14 articles (01/2018 - 09/2004)
2.	Feldmann, Heinz: 11 articles (11/2020 - 10/2006)
3.	Marzi, Andrea: 7 articles (11/2020 - 11/2004)
4.	Takada, Ayato: 7 articles (11/2020 - 10/2006)
5.	Hensley, Lisa E: 6 articles (01/2020 - 09/2012)
6.	Bukreyev, Alexander: 5 articles (11/2021 - 01/2017)
7.	Becker, Stephan: 5 articles (01/2019 - 11/2004)
8.	Olinger, Gene G: 5 articles (11/2018 - 11/2005)
9.	Aman, M Javad: 5 articles (01/2018 - 09/2004)
10.	Dye, John M: 5 articles (01/2018 - 11/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Filoviridae Infections:

1.	VaccinesIBA 06/01/2011 - "A variety of vaccine platforms have been shown to be effective against filovirus infection. " 01/01/2014 - "These vaccines have shown 100% efficacy against filovirus infection in nonhuman primates when challenge occurs 28-35 days after a single injection immunization. " 11/01/2021 - "Understanding the role of antibody responses during natural filovirus infections is important for the development of safe and potent vaccines and antibody-based treatments." 09/01/2012 - "Potential vaccines and post-exposure treatments for filovirus infections." 05/01/2011 - "This article focuses on information relevant for health care practitioners in travel medicine to include, the epidemiology and clinical features of filovirus infection and efforts toward development of a filovirus vaccine."
2.	Virus-Like Particle VaccinesIBA 04/01/2008 - "Protection against filovirus infection: virus-like particle vaccines." 04/01/2008 - "This review briefly summarizes filovirus epidemiology and pathogenesis, and focuses on the discussion of recent advances in filovirus vaccine development and the current understanding of protective immune responses against filovirus infection with an emphasis on the progress and challenge of filovirus virus-like particle vaccine development."
3.	Antisense RNA (Anti-Sense RNA)IBA 11/15/2007 - "In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics."
4.	NucleosidesIBA 03/24/2016 - "Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl-4-aza-7,9-dideazaadenosine C-nucleoside, have been recently described as effective against filovirus infections (Marburg) and hepatitis C virus (HCV), respectively. "
5.	Immunologic Factors (Immunomodulators)IBA 05/01/1995 - "[The efficacy of the emergency prophylactic and therapeutic actions of immunomodulators in experimental filovirus infections]."
6.	galidesivirIBA 03/24/2016 - "Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl-4-aza-7,9-dideazaadenosine C-nucleoside, have been recently described as effective against filovirus infections (Marburg) and hepatitis C virus (HCV), respectively. "
7.	favipiravirIBA 01/01/2018 - "However, there are no published reports of favipiravir efficacy for filovirus infection of nonhuman primates (NHPs). "
8.	phosphoramidic acidIBA 03/24/2016 - "Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl-4-aza-7,9-dideazaadenosine C-nucleoside, have been recently described as effective against filovirus infections (Marburg) and hepatitis C virus (HCV), respectively. "
9.	GS-6620IBA 03/24/2016 - "Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl-4-aza-7,9-dideazaadenosine C-nucleoside, have been recently described as effective against filovirus infections (Marburg) and hepatitis C virus (HCV), respectively. "
10.	Glycoproteins (Glycoprotein)IBA 01/01/2021 - "The filovirus infection is mediated by the interaction of viral envelope glycoprotein (GP) and the human endosomal receptor Niemann-Pick C1 (NPC1). " 01/01/2019 - "To define a minimal set of host factors required for filoviral glycoprotein-driven cell entry, we screened twelve cell lines and identified the nonlymphocytic cell line SH-SY5Y to be specifically resistant to filovirus infection. " 11/22/2018 - "Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. " 01/01/2018 - "Hundreds of mAbs have been isolated from human survivors of filovirus infections that target the viral spike glycoprotein (GP). " 01/01/2018 - "mAbs against the envelope glycoprotein represent a promising therapeutic platform for managing filovirus infections. "

Therapies and Procedures

1.	Therapeutics 09/01/2010 - "Advanced antisense therapies for postexposure protection against lethal filovirus infections." 11/22/2018 - "No therapeutics are approved for the treatment of filovirus infections. " 01/01/2017 - "Therapies for filovirus infections are urgently needed. " 01/01/2017 - "Therapeutics Against Filovirus Infection." 01/01/2015 - "For filovirus researchers and government agencies interested in making treatments available for a nation's defense as well as its general public, having the right diagnostic tools to identify filovirus infections, as well as a panel of available therapeutics for treatment when needed, is a high priority. "
2.	Investigational Therapies (Experimental Therapy) 04/01/2002 - "Experimental therapy of filovirus infections." 06/01/2004 - "S-Adenosyl-L-homocysteine hydrolase (SAHh) inhibitors have long been used as broad-range antivirals and have been recently evaluated as an experimental therapy of filovirus infections. "
3.	Resuscitation 06/01/2015 - "Early, aggressive supportive care is the mainstay of Filovirus infection management with massive fluid resuscitation as the key management principle. "
4.	Drug Therapy (Chemotherapy) 01/01/2016 - "Filoviruses are highly infectious, and no FDA-approved drug therapy for filovirus infection is available. "