Second-Generation Antidepressive Agents

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.

Also Known As:

Antidepressive Agents, Second-Generation; Antidepressive Drugs, Second-Generation; Agents, Second-Generation Antidepressive; Antidepressive Agents, Second Generation; Antidepressive Drugs, Second Generation; Drugs, Second-Generation Antidepressive; Second Generation Antidepressive Agents; Second-Generation Antidepressive Drugs; Antidepressants, Atypical; Atypical Antidepressants

Networked: 27 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Central Nervous System Agents: 51
      - Psychotropic Drugs: 3130
        Antidepressive Agents: 19801
        Second-Generation Antidepressive Agents: 27

Experts

1.	Patel, Rikinkumar S: 1 article (08/2020)
2.	Veluri, Nikhila: 1 article (08/2020)
3.	Verma, Geetika: 1 article (08/2020)
4.	Alpérovitch, Annick: 1 article (01/2020)
5.	Debette, Stephanie: 1 article (01/2020)
6.	Duan, Li: 1 article (01/2020)
7.	Fu, Chunfeng: 1 article (01/2020)
8.	Gao, Yunfeng: 1 article (01/2020)
9.	Mazoyer, Bernard: 1 article (01/2020)
10.	Shao, Xiaojun: 1 article (01/2020)

Related Diseases

1.	Chronic Pain 07/29/2019 - "The most commonly used antidepressants for chronic pain are tricyclic antidepressants (TCAs), though selective serotonin or noradrenaline reuptake inhibitors and other atypical antidepressants have been shown to be effective at treating chronic pain. " 01/01/2013 - "These new drugs that are effective for chronic pain belong to the tetracyclic antidepressants (TeCAs) group (amoxapine, maprotiline), the serotonin and noradrenaline reuptake inhibitors (SNRIs) group (duloxetine, venlafaxine, milnacipran) and the atypical antidepressants group (bupropion, trazodone, mirtazapine, nefazodone). "
2.	Catatonia 08/19/2020 - "Relatively very few studies have examined the use of atypical antidepressants, such as mirtazapine, and so we present a case of catatonia due to severe depression with psychotic features that improved significantly after the introduction of mirtazapine. "
3.	Bipolar Disorder (Manic Depressive Psychosis) 11/01/2009 - "Other therapies used for bipolar disorder, including several mood stabilizers, antidepressants, atypical antipsychotics and benzodiazepines, have been shown to reduce anxiety symptoms, but specific data for their effects in patients with anxiety symptoms co-morbid with bipolar disorder are not available. " 04/01/2016 - "The proportion of patients with bipolar disorder using antidepressants, atypical antipsychotics and anticonvulsants increased over the study period, while the proportion of patients using lithium, typical antipsychotics and benzodiazepines/sedatives decreased. " 11/05/2013 - "The keywords "bipolar disorder, bipolar I disorder, bipolar II disorder, bipolar mania, bipolar depression, cyclothymia, mixed mania and depression, rapid cycling and bipolar disorder", AND "antidepressant agent, antidepressive agents second- generation, antidepressive agents tricyclic, monoamine oxidase inhibitor, noradrenaline uptake inhibitor, serotonin uptake inhibitor, and tricyclic antidepressant agent" were used. "
4.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/01/2003 - "This review examines some of the basic neurobiological abnormalities observed in PTSD and summarizes open and controlled drug trials for major classes of medications, including SSRIs, other antidepressants, atypical neuroleptics, noradrenergic modulators and anticonvulsants, while critically evaluating the extent of effectiveness of these agents and reviewing unmet gaps in therapeutic need."
5.	Marijuana Abuse (Cannabis Abuse) 01/01/2014 - "The quantitative analyses that were possible, combined with general findings of the studies reviewed, indicate that SSRI antidepressants, mixed action antidepressants, atypical antidepressants (bupropion), anxiolytics (buspirone) and norepinephrine reuptake inhibitors (atomoxetine) are probably of little value in the treatment of cannabis dependence. "

Related Drugs and Biologics

1.	Antidepressive Agents (Antidepressants)
2.	Mirtazapine (Rexer)
3.	Norepinephrine (Noradrenaline)
4.	Bupropion (Wellbutrin)
5.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)
6.	Serotonin and Noradrenaline Reuptake Inhibitors
7.	Trazodone (Trittico)
8.	Serotonin (5 Hydroxytryptamine)
9.	Venlafaxine Hydrochloride (Effexor)
10.	Maprotiline (Ludiomil)

Related Therapies and Procedures

1.	Therapeutics