Intravenous Anesthetics

Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)

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Networked: 290 relevant articles (15 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Inada, Takefumi: 6 articles (02/2021 - 01/2009)
2.	Shingu, Koh: 5 articles (08/2017 - 01/2009)
3.	Hirota, Kiichi: 3 articles (01/2019 - 07/2015)
4.	Tao, Tao: 3 articles (11/2016 - 09/2011)
5.	Kubo, Kozue: 3 articles (08/2011 - 01/2009)
6.	Tang, Jing: 2 articles (11/2021 - 11/2016)
7.	Kamibayashi, Takahiko: 2 articles (02/2021 - 08/2017)
8.	Qi, Sihua: 2 articles (01/2021 - 10/2010)
9.	Sutter, Raoul: 2 articles (09/2020 - 04/2013)
10.	Han, Ding: 2 articles (06/2020 - 12/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Recent studies have shown that intravenous anesthetic drugs may affect the malignant behaviors of tumor cells, ultimately leading to differences in the postoperative prognosis of patients. " 11/01/2012 - "In the present study, the cytotoxicity of five intravenous anesthetics towards oral tumor and normal cells was compared. " 07/22/2022 - "Volatile and/or intravenous anesthetics are generally used for cancer curative surgeries. " 11/01/2012 - "Intravenous anesthetics have been used during the treatment of various malignant tumors, however, their effects on oral tissues is not well-understood. " 01/01/2022 - "(1) A variety of intravenous anesthetics may affect metastasis or tumor growth, though the evidence is contradictory and inconsistent, and the clinical data are still inconclusive. "
2.	Obstructive Jaundice (Cholestatic Jaundice) 03/28/2014 - "Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice." 01/08/2022 - "The effect of obstructive jaundice on the sensitivity of intravenous anesthetic of remimazolam: study protocol for a controlled multicenter trial." 11/01/2009 - "The effects of obstructive jaundice on the pharmacodynamics of propofol: does the sensitivity of intravenous anesthetics change among icteric patients?" 03/28/2014 - "The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure." 01/01/2012 - "In this study, we investigated the protective effects of frequently used intravenous anesthetics (ketamine, propofol, thiopental, and fentanyl) in oxidative stress in a rat liver model of obstructive jaundice. "
3.	Sepsis (Septicemia) 09/01/2005 - "This review focuses on an area in which alternative actions of intravenous anesthetics show much promise for sepsis: their effects on the inflammatory response and on inflammatory cells in vitro and in vivo. " 09/01/2005 - "Intravenous anesthetics in sepsis." 05/01/2006 - "On the contrary, intravenous anesthetics may be more protective against sepsis-induced hepatic injury than volatile anesthetics." 11/01/2000 - "Sepsis elicits manifold alterations in the influence of intravenous anesthetics and sedatives on NDMR-induced neuromuscular blockade." 01/01/2020 - "The goal of this study was to study the impact of Sepsis-inflammation on hepatic subcellular energetics in animals anesthetized with both Propofol (intravenous anesthetic agent and GABA agonist) and Isoflurane (volatile anesthetic i.e., VAA). "
4.	Reperfusion Injury 01/01/2014 - "The effects of intravenous anesthetics on ischemia-reperfusion injury (IRI) have been investigated in both animals and clinical studies. " 03/01/2008 - "The aim of the present study was to investigate the underlying mechanisms in the preventive effects of intravenous anesthetics on testicular ischemia-reperfusion injury. " 01/01/2018 - "Intravenous Anesthetics Enhance the Ability of Human Bone Marrow-Derived Mesenchymal Stem Cells to Alleviate Hepatic Ischemia-Reperfusion Injury in a Receptor-Dependent Manner." 01/01/2014 - "The effects of spinal, inhalation, and total intravenous anesthetic techniques on ischemia-reperfusion injury in arthroscopic knee surgery." 01/01/2014 - "The effect of intravenous anesthetics on ischemia-reperfusion injury."
5.	Hypotension (Low Blood Pressure) 05/01/2016 - "Prewarming with convective forced air for one hour prior to intravenous anesthetic induction did not prevent hypotension during the induction period (Australian New Zealand Clinical Trials Registry [ANZCTR] ACTRN12615000431527)." 01/01/2017 - "Most intravenous anesthetic drugs produce hypotension and respiratory suppression; therefore, patients with RSE are managed in intensive care units (ICUs). " 07/01/2006 - "Hypotension was traced in a very high percentage of cases due to unawareness and ignorance of pre-anesthetic intravenous fluid loading by concerned staff. " 08/01/2001 - "The mechanisms of arterial hypotension following intravenous anesthetic induction agents are multifactorial. " 01/01/2022 - "However, the conventional induction strategy for anesthesia using high-dose intravenous anesthetics is often associated with persistent and recurrent hypotension after tracheal intubation. "

Related Drugs and Biologics

1.	Propofol (Diprivan)
2.	Anesthetics (Anesthetic Agents)
3.	Thiopental (Pentothal)
4.	Opioid Analgesics (Opioids)
5.	Ketamine
6.	Etomidate
7.	Fentanyl (Sublimaze)
8.	barbituric acid (barbiturate)
9.	Local Anesthetics
10.	Cyclooxygenase 2 (Cyclooxygenase-2)

Related Therapies and Procedures

1.	Anesthesia
2.	General Anesthesia
3.	Intravenous Anesthesia
4.	Analgesia
5.	Intravenous Infusions