Adrenergic Agents (Adrenergic Drugs)

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Also Known As:

Adrenergic Drugs; Adrenergics; Agents, Adrenergic; Adrenergic Effect; Adrenergic Effects; Adrenergic Neurohumor Depleters; Adrenergic Neuron Drugs; Agent, Adrenergic; Agents, Adrenergic Neuron; Depleters, Adrenergic Neurohumor; Drug, Adrenergic; Drugs, Adrenergic; Drugs, Adrenergic Neuron; Effect, Adrenergic; Effects, Adrenergic; Inhibitors, Adrenergic Release; Inhibitors, Adrenergic Synthesis; Neurohumor Depleters, Adrenergic; Neuron Agents, Adrenergic; Neuron Drugs, Adrenergic; Release Inhibitors, Adrenergic; Releasers, Sympathetic Transmitter; Synthesis Inhibitors, Adrenergic; Transmitter Releasers, Sympathetic; Adrenergic; Adrenergic Agent; Adrenergic Drug; Adrenergic Neuron Agents; Adrenergic Release Inhibitors; Adrenergic Synthesis Inhibitors; Sympathetic Transmitter Releasers

Networked: 9549 relevant articles (309 outcomes, 881 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Adrenergic Agents: 9549
        Adrenergic Agonists: 806
        Adrenergic Antagonists: 736
        Adrenergic Uptake Inhibitors: 2
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Adrenergic Agents: 9549
        Adrenergic Agonists: 806
        Adrenergic Antagonists: 736
        Adrenergic Uptake Inhibitors: 2

Experts

1.	Grassi, Guido: 36 articles (01/2021 - 03/2003)
2.	Sood, Anil K: 26 articles (07/2020 - 08/2006)
3.	Koch, Walter J: 23 articles (01/2018 - 01/2000)
4.	Mancia, Giuseppe: 22 articles (01/2020 - 03/2003)
5.	Seravalle, Gino: 19 articles (12/2020 - 03/2003)
6.	Cole, Steve W: 17 articles (07/2020 - 11/2005)
7.	Lutgendorf, Susan K: 17 articles (07/2020 - 08/2006)
8.	Quarti-Trevano, Fosca: 12 articles (01/2021 - 03/2007)
9.	Sloan, Erica K: 12 articles (01/2021 - 09/2010)
10.	Dell'Oro, Raffaella: 12 articles (01/2020 - 05/2005)

Related Diseases

1.	Heart Failure 06/01/2004 - "Additional studies are needed to fully understand whether there are any advantages of selective versus nonselective adrenergic blockade and whether there are any clinically meaningful differences in effectiveness between beta-blockers with proven benefit in the management of chronic heart failure. " 05/01/1999 - "Neurohormonal activation and chronic adrenergic overstimulation appear to play important roles in mediating the progressive pathophysiology of congestive heart failure (CHF), and the beneficial effects of beta-blockade in the management of chronic heart failure have been demonstrated by multiple clinical trials over the last decade. " 01/01/2018 - "Taken together, our data suggest exercise training is beneficial for cardiomyocyte function via the effects on Ca2+ homeostasis and adrenergic sensitivity in a large animal model of pressure overload-induced heart failure. " 01/01/2008 - "Beta-blockers have been used successfully to treat chronic heart failure based on the premise that chronically elevated adrenergic drive is detrimental to the myocardium. " 04/01/2005 - "These results strengthen the notion that overexpression of SOR improves cardiac contractility independent of beta-adrenergic stimulation and may prove beneficial in the treatment of decreased cardiac output such as heart failure."
2.	Myocardial Infarction 12/01/2002 - "Both left ventricular dP/dt(max) and left ventricular dP/dt(min) responses to increased preload and to beta-adrenergic stimulation progressively improved to a significantly higher level after 30 days of left ventricular unloading for the hearts that were transplanted 4 weeks after myocardial infarction. " 02/01/2002 - "Beta-adrenergic blockade has in several studies been shown to improve survival after myocardial infarction. " 01/01/2015 - "Adipose stem cell sheets improved cardiac function in the rat myocardial infarction, but did not alter cardiac contractile responses to β-adrenergic stimulation." 01/01/2014 - "Thus, βARKct engineering of CPCs promotes survival and proliferation of injected cells following myocardial infarction, which includes improved β-adrenergic tolerance essential for stem cell survival. " 01/10/2021 - "To study the change in the -adrenergic reactivity of red blood cell membranes in patients during the first year after acute myocardial infarction. "
3.	Neoplasms (Cancer) 01/01/2019 - "Overall, we found that adrenergic stress significantly impaired the anti-tumor efficacy of radiation by inducing tumor cell resistance to radiation-induced cell killing and by suppression of anti-tumor immunity. " 07/01/2012 - "This case shows that a sequential management strategy of damage-control surgical treatment followed by future resection of the tumors after appropriate a-adrenergic blockade is a safe and effective therapeutic option." 12/20/2020 - "In this review article, we present data on the potential for adrenergic stress to influence the efficacy of radiation and in particular, its potential to influence the anti-tumor immune response, and the frequency of an "abscopal effect" or the shrinkage of tumors which are outside an irradiated field. " 08/01/2017 - "Recent retrospective studies suggest that beta-adrenergic blocking drugs (BB) are associated with improved outcomes in patients with a range of cancers. " 06/30/2022 - "Studies suggest that the adrenergic pathway is directly involved in sympathetic-driven hematopoietic activation of pro-tumor microenvironmental proliferation and tumor cell trafficking into the circulation. "
4.	Hypertension (High Blood Pressure) 01/01/2013 - "Adrenergic control of cerebral vascular resistance becomes effective in newborn lambs within two-weeks after birth but SCG-dependent autoregulation is essential only during pronounced hypertension, well above the normal range of blood pressure. " 06/28/2005 - "Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension." 12/01/1993 - "Improved baroreflex control of the heart rate with chronic beta-adrenergic blockade in mild hypertension." 01/28/1982 - "Such treatment attenuated but did not abolish the hypertension which was only eliminated by subsequent alpha-adrenergic blockade. " 01/01/2018 - "This study aims to understand the morphological, molecular and phenotypic changes because of excess CHGA and the mechanistic link eventuating in hyper-adrenergic hypertension. "
5.	Tachycardia (Tachyarrhythmias) 01/01/1986 - "Therapeutic efficacy is only to be expected if an increased adrenergic drive is a prerequisite for induction and continuation of a tachycardia." 08/01/1995 - "Concomitant ACEI with chronic tachycardia reduced LV chamber dilation and improved myocyte contractile function and beta-adrenergic responsiveness. " 01/01/1979 - "Unbalancing of the sympathetic supply with the parasympathetic supply totally obliterated, leads to tachycardias of various origin which are eliminated by adrenergic blockade. " 03/01/1995 - "All patients with undiagnosed tachycardias should have full repeat stimulation studies during adrenergic stimulation if the initial baseline evaluation is nondiagnostic." 06/01/1990 - "The doses employed in this study (320 mg/day) produced mild to moderate degrees of beta-adrenergic blockade as suggested by: a 20% reduction in the mean heart rate on 48 h Holter monitoring (P less than 0.0005); a 15 to 30% reduction in tachycardia induced by strenuous exercise; and a 12% reduction in standing-induced tachycardia. "

Related Drugs and Biologics

1.	Propranolol (Inderal)
2.	Cholinergic Agents (Cholinergics)
3.	Adrenergic Receptors (Adrenergic Receptor)
4.	Isoproterenol (Isoprenaline)
5.	Norepinephrine (Noradrenaline)
6.	Epinephrine (Adrenaline)
7.	Catecholamines
8.	Antidepressive Agents (Antidepressants)
9.	Metoprolol (Toprol-XL)
10.	Dopamine (Intropin)

Related Therapies and Procedures

1.	Therapeutics
2.	Denervation
3.	Drug Therapy (Chemotherapy)
4.	Ligation
5.	Anesthesia