|4.||Gastroesophageal Reflux (GERD)
|1.||Parkman, Henry P: 35 articles (12/2015 - 01/2002)|
|2.||McCallum, Richard W: 18 articles (12/2015 - 05/2004)|
|3.||Abell, Thomas L: 16 articles (12/2015 - 01/2002)|
|4.||Hasler, William L: 15 articles (12/2015 - 07/2002)|
|5.||Pasricha, Pankaj J: 14 articles (12/2015 - 02/2002)|
|6.||Farrugia, Gianrico: 14 articles (12/2015 - 12/2008)|
|7.||Koch, Kenneth L: 9 articles (12/2015 - 08/2003)|
|8.||Sarosiek, Irene: 9 articles (12/2015 - 05/2002)|
|9.||Parkman, H P: 9 articles (11/2015 - 09/2009)|
|10.||Tack, J: 8 articles (09/2013 - 07/2003)|
|1.||Cisapride (Propulsid)FDA Link
07/01/1997 - "Thus long-term cisapride therapy at the study dose produced long-term symptomatic improvement in 42% of patients with severe gastroparesis, with sustained acceleration of gastric emptying for up to 2 years."
01/01/1989 - "Diabetic gastroparesis In a four week study, cisapride has been shown to be effective in improving symptoms and solid phase gastric emptying. "
04/10/1995 - "The gastrointestinal prokinetic drug, cisapride, is widely used for the treatment of diabetic gastroparesis and disorders of gastrointestinal motility. "
10/01/1995 - "[Influence on glycemic control of improved diabetic gastroparesis by long-term cisapride therapy]."
01/01/1994 - "However, the efficacy of cisapride in end-stage gastroparesis remains less clear. "
|2.||Metoclopramide (Reglan)FDA LinkGeneric
04/01/2014 - "Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet."
09/01/1983 - "Metoclopramide is an effective agent for improving the upper gastrointestinal motor function in diabetic patients with gastroparesis."
02/01/1985 - "The aims of our study were to: determine the effect of metoclopramide parenterally and orally on delayed gastric emptying of a radionuclide test meal in symptomatic patients with diabetic gastroparesis not explained by ulceration or other mechanical problems; and evaluate in a double-blind crossover fashion the efficacy of metoclopramide in relieving the symptoms of diabetic gastroparesis. "
01/01/2003 - "To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis. "
12/01/1983 - "All diabetic patients with gastroparesis had prolonged gastric emptying time, and all responded favorably to metoclopramide. "
|3.||Erythromycin (Erycette)FDA LinkGeneric
02/01/2003 - "Although clearly a potent prokinetic, limited data exist concerning efficacy of erythromycin in treating gastroparesis. "
03/01/1999 - "Intravenous erythromycin is a potent gastric prokinetic with demonstrated efficacy in the acute therapy of gastroparesis; long-term oral therapy has been limited by tolerance and modest efficacy. "
10/01/1994 - "Gastric emptying was accelerated by erythromycin via an antroduodenal coordination mechanism, an effect that has proved to be beneficial in surgical and medical conditions in which gastroparesis is a problem. "
03/01/1999 - "Prolonged administration of intravenous erythromycin in an ambulatory setting is feasible, well tolerated, and effective in patients with severe gastroparesis."
09/01/1995 - "We conclude that erythromycin is an effective prokinetic agent for diabetic gastroparesis, and that improved oesophageal transit and gastric emptying may improve glycaemic control."
|4.||Botulinum Toxins (Botulinum Toxin)IBA
02/01/2008 - "The first published controlled trial of intrapyloric botulinum toxin for gastroparesis failed to demonstrate a significant effect of treatment on symptoms, despite an improvement in gastric emptying. "
08/15/2006 - "Botulinum toxin improves solid but not liquid gastric emptying in gastroparesis, and this is accompanied by significant improvement of several meal-related symptoms."
01/01/2006 - "Intrapyloric injection of botulinum toxin A (BoTx) successfully improved symptoms in idiopathic and diabetic gastroparesis (DGP) refractory to medical treatment. "
02/01/2015 - "Gastrointestinal: botulinum toxin effective in refractory gastroparesis in paediatric practice."
07/15/2008 - "Intrapyloric injection of botulinum toxin is effective in improving the complex symptoms and clinical syndrome associated with diabetic gastroparesis resistant to conventional treatment. "
05/01/1998 - "The results of this study suggest that domperidone 20 mg QID provides significant improvement in the upper gastrointestinal symptoms of diabetic gastroparesis and is well tolerated in patients with this condition."
07/01/2008 - "Overall, our assessment is that there is level 3 evidence for the efficacy of domperidone in diabetic gastroparesis, leading to a grade C recommendation for its use in this condition. "
07/01/2008 - "Our objective was to systematically analyze studies of the efficacy of domperidone in diabetic gastroparesis, with a focus on their methodologic and scientific merit. "
07/01/2008 - "A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis."
04/01/2014 - "The aim of this preliminary study was to compare the effectiveness of domperidone and acupuncture for the management of diabetic gastroparesis. "
04/01/1995 - "The myoelectrical and motor response of the antropyloroduodenal region to intraduodenal nutrient stimulation or antral tachygastria represent useful models for, respectively, physiological and pathophysiological gastric stasis to test the efficacy of prokinetic drugs. "
02/01/2009 - "Combined with previously reported findings (enhanced antral contractions and accelerated gastric emptying) and findings in this study (improved gastric accommodation and slow waves), SGES may be a viable therapy for gastroparesis."
03/01/2015 - "We hypothesized that concomitant small bowel dysmotility may play a role in symptom causation in gastroparesis and sought to test this hypothesis by using wireless motility capsule (WMC) testing to simultaneously measure antral and duodenal area under pressure curve (AUC) in patients with delayed gastric emptying. "
03/01/2015 - "Duodenal rather than antral motility contractile parameters correlate with symptom severity in gastroparesis patients."
07/01/2014 - "Diabetic gastroparesis (delayed gastric emptying) is associated with antral hypomotility. "
07/25/2014 - "The synthetic ghrelin mimetic RM-131 is in Phase II clinical trials for treatment of diabetic gastroparesis and other gastrointestinal (GI) disorders. "
11/01/2013 - "This viewpoint assesses the potential role of ghrelin agonists in the treatment of gastroparesis through a review of the early phase, randomized, controlled trials of ghrelin agonists in patients with diabetes and, either, delayed gastric emptying at the time of the trial or symptoms at the time of the trial, and prior documentation of delayed gastric emptying of solids. "
01/01/2013 - "Ghrelin agonists have been developed for the treatment of hypomotility disorders and the peptidomimetic TZP-102 is in phase 2 clinical trials for diabetic gastroparesis."
06/01/2010 - "Ghrelin is produced by enteroendocrine cells in the gastric mucosa and stimulates gastric emptying in healthy volunteers and patients with gastroparesis in short-term studies. "
08/01/2006 - "In this study we aimed  to investigate the presence of vagal nerve dysfunction in patients with idiopathic and diabetic gastroparesis and  to determine if alterations in ghrelin concentrations occur in gastroparesis. "
|8.||Insulin (Novolin)FDA Link
05/06/2013 - "The present study suggests that prokinetic drugs could potentially improve glycemic control in diabetic gastroparesis by allowing a more predictable absorption of nutrients, matched to the action of exogenous insulin. "
01/01/2005 - "We performed a prospective single center study on the long-term effect (12 months) of continuous high-frequency/low-energy GES on symptoms, gastric emptying (measured scintigraphically), and metabolic control (HbA1c) in insulin-dependent diabetic subjects suffering from drug-refractory gastroparesis for more than one year. "
03/01/1984 - "preoperative values, negative postoperative insulin test results, complete absence of gastric stasis and a mean normal gastric emptying time in isotope gastric emptying studies was demonstrated."
03/01/2014 - "56 subjects with insulin treated DM and gastroparesis were randomized to the intervention diet or the control diet. "
03/01/2014 - "Our aim was to compare GI symptoms in insulin treated DM subjects with gastroparesis eating a diet with small particle size ("intervention diet") with the recommended diet for DM ("control diet"). "
|9.||Glucose (Dextrose)FDA LinkGeneric
08/01/2007 - "An understanding of gastric motility in T2DM is important to diagnose gastroparesis, to treat upper gastrointestinal symptoms, and to restore normal gastric motility, which may lead, in turn, to improved glucose control."
05/01/2004 - "In diabetic patients with refractory gastroparesis, high-frequency GES by a permanently implanted system significantly improved upper GI symptoms, HQOL, nutritional status, glucose control, and hospitalizations with an acceptably low complication rate."
07/01/2014 - "This study evaluated the plasma glucose response after a test meal, and gastrointestinal (GI) symptom severity in patients with clinical suspicion of diabetic gastroparesis, and assessed its usefulness to predict gastroparesis. "
03/01/2011 - "The primary aim of this study was to compare measurements of GE of a high-nutrient glucose drink by 3D ultrasonography and scintigraphy in diabetic gastroparesis. "
06/01/2015 - "Patients with diabetic gastroparesis completed: (1) Demographic Questionnaire assessing type of diabetes, associated symptoms and control of glucose and (2) Patient Assessment of GI Symptoms assessing symptoms severity. "
07/01/2007 - "Mitemcinal can induce a statistically significant response to treatment in a subset of diabetic gastroparesis where future prokinetic clinical trials should be focused."
06/05/2009 - "Currently, oral mitemcinal has been focused on diabetic gastroparesis under clinical development. "
06/05/2009 - "Motilides: a long and winding road: lessons from mitemcinal (GM-611) on diabetic gastroparesis."
07/01/2008 - "These results add to the existing evidence that mitemcinal is likely to be useful for treating diabetic gastroparesis."
10/15/2007 - "Mitemcinal is capable of accelerating gastric emptying in both diabetic and idiopathic patients with gastroparesis."
01/01/2013 - "Laparoscopic subtotal gastrectomy should also be considered as one of the primary surgical treatments for gastroparesis given the significantly higher rate of symptomatic improvement with acceptable morbidity and comparable mortality. "
10/01/2003 - "Completion gastrectomy seems effective for postsurgical gastroparesis, but a cautious approach is warranted before surgical therapies in diabetic or idiopathic gastroparesis are used."
11/01/1999 - "Is gastroparesis in diabetes cured by gastrectomy?"
06/01/1999 - "Gastroparesis cured by gastrectomy."
01/01/2013 - "The aim of this study was to investigate the differences and influencing factors for postsurgical gastroparesis syndrome incidence after laparoscopic and open radical gastrectomy. "
|2.||Drug Therapy (Chemotherapy)
06/01/2013 - "Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives."
01/01/2013 - "The pathophysiology and drug therapy of gastroparesis are focused in this review. "
01/01/2013 - "As the progress in the pathophysiology of gastroparesis has been made, a promising new drug therapy has been found. "
10/01/2010 - "Pharmacotherapy for gastroparesis: an attempt to evaluate a safer alternative."
02/01/2009 - "Pharmacotherapy of gastroparesis."
|3.||Nutritional Support (Artificial Feeding)
10/01/1996 - "A prospective study of J-tube placement and other available means of nutritional support is needed to demonstrate further the efficacy of this intervention in patients with severe diabetic gastroparesis."
12/01/2012 - "Nutritional support during the post-operative period on a cyclical basis is preferred because it is associated with low incidence of gastric stasis. "
08/01/2012 - "PEJ insertion is a feasible technique, which could help to provide nutritional support for patients with gastroparesis and previous lung transplantation."
06/28/2005 - "From April 2002 to January 2004, 21 consecutive patients with gastroparesis or gastroesophageal wounds were enrolled and received nasoenteric feeding for nutritional support. "
10/01/2013 - "Using population statistics and the State Inpatient Database (Agency for Healthcare Research and Quality), regional differences in admissions for gastroparesis, inpatient mortality, length of stay, nursing home transfers, and rates of endoscopy, gastrostomy placement, and nutritional support were assessed. "
|4.||Gastric Bypass (Roux-en-Y Gastric Bypass)
09/01/2014 - "The objective of this study was to describe treatment of recalcitrant gastroparesis in obese adults with Roux-en-Y gastric bypass (RYGB) surgery. "
09/01/2014 - "Gastric bypass surgery as treatment of recalcitrant gastroparesis."
09/01/2014 - "Comment on: gastric bypass surgery as a primary treatment of recalcitrant gastroparesis."
12/01/2007 - "Gastroparesis is a rare complication of Roux-en-Y gastric bypass. "
12/01/2007 - "Refractory gastroparesis after Roux-en-Y gastric bypass: surgical treatment with implantable pacemaker."
10/01/2006 - "To study the risk factors of postoperative gastroparesis syndrome after pancreaticoduodenectomy. "
09/01/2012 - "Gastric stasis is a unique complication of pylorus-preserving pancreatoduodenectomy (PPPD). "
05/01/2009 - "Since gastroparesis is unavoidable in a certain proportion of patients after pancreaticoduodenectomy, measures to avoid its occurrence or at least minimize its impact are needed. "
11/01/2008 - "To investigate the prevention and treatment for postsurgical gastroparesis syndrome (PGS) after pancreaticoduodenectomy. "
11/01/2008 - "[Clinical analysis of 18 cases with postsurgical gastroparesis syndrome after pancreaticoduodenectomy]."