|3.||Body Weight (Weight, Body)
|1.||Dorsey, Grant: 13 articles (01/2015 - 05/2006)|
|2.||Rosenthal, Philip J: 12 articles (11/2014 - 05/2006)|
|3.||Duffy, Patrick E: 10 articles (01/2014 - 08/2003)|
|4.||Perkins, Douglas J: 10 articles (01/2013 - 11/2003)|
|5.||Lang, Florian: 10 articles (10/2010 - 01/2008)|
|6.||Kremsner, Peter G: 10 articles (01/2009 - 02/2003)|
|7.||Mueller, Ivo: 9 articles (12/2014 - 05/2002)|
|8.||Nahlen, Bernard L: 9 articles (07/2007 - 07/2002)|
|9.||Anstey, Nicholas M: 8 articles (01/2015 - 09/2002)|
|10.||Troye-Blomberg, Marita: 8 articles (05/2014 - 10/2003)|
|1.||Chloroquine (Aralen)FDA LinkGeneric
01/01/2006 - "Age effect on the clearance of parasitemia was evident in both areas, more significantly though in Gedaref (P<0.000) than Haj Yousif (P=0.043) These results add to reports in the literature, pointing to the complexity of factors that may contribute to a clinical outcome following chloroquine treatment, particularly, in this case are elements of the host immunity that are yet to be identified."
11/01/2003 - "At day 5 (D5), 57% of chloroquine-treated and 52% of N'Dribala-treated patients were cured with no detectable parasitemia (parasite density (Pd): 0) and more than 90% of whole patients were asymptomatic. "
05/01/1997 - "Currently, there is no established treatment for Plasmodium vivax parasitemias that are not cured by chloroquine. "
08/01/2009 - "Three subjects had recurrent parasitemia on Days 14 and 28, but with chloroquine < 100 ng/mL. Eleven subjects cleared parasitemia by Day 3 and had no recurrences up to Day 28. "
09/01/2006 - "All patients cleared parasitemia within 7 days after chloroquine treatment. "
|2.||Immunoglobulin G (IgG)IBA
03/01/2003 - "IgG(3) levels declined sharply within 6 weeks of pharmacological clearance of parasitemia in all subjects, whereas a significant decrease in IgG(1) levels was seen only in subjects < or =19 years old. "
09/01/2002 - "Following antimalarial treatment, clearance of parasitemia led to a fall in anti-GPI IgG response in children and adolescents within 6 weeks. "
03/01/2015 - "In addition, an increase of IgG responses against MSP1p19 is highly observed in adults having a parasitemia less than 1%. "
03/01/2015 - "Levels of IgG anti-MSP3 were higher in patients with low parasitemia (≤1%) and appear negatively correlated to parasite densities (Rho =. "
01/01/2015 - "A biomarker of humoral immunity, IgG levels, can also be integrated into the framework, potentially mediating the impact of polymorphism by limiting parasitemia levels. "
11/01/2012 - "The overall parasite clearance times were prolonged compared with the clearance times in a previous study at this site in 2006 to 2007, but this did not persist when the evaluation was limited to subjects with a comparable artesunate dose (4 mg/kg/day) and baseline parasitemia from the two studies. "
10/01/2013 - "Suppression of parasitemia by artesunate and methanolic extract of T. "
01/01/2013 - "Fourteen of 52 participants (26.9%) had a measurable parasitemia 72 hours after initiating artesunate treatment. "
03/01/2012 - "Compound 4g presented better activity then the reference artesunate in percentage of inhibition of parasitemia in treated P. "
01/15/2012 - "The total dose of artesunate in each group was 12 mg/kg. The primary end point was the proportion of children clearing ≥ 99% of their admission parasitemia at 24 hours. "
|4.||Quinine (Quinson)FDA Link
09/01/1991 - "Initial parasitemias were eradicated by a curative treatment with quinine, a drug with a short elimination half-life, to minimize the effects of residual drug on reinfection. "
09/01/2005 - "The time to a 4-log reduction of the initial level of parasitemia (Ter) was related to the average quinine concentration from 0 to 72 h (Cav) as Ter = Tmin [1 + (C50/Cav)s], where sigmoidicity (s) is equal to 2, Tmin is the time to eradication at infinite Cav, and C50 is the value of Cav for which Ter is twice Tmin. "
09/01/2005 - "Quinine concentrations in plasma samples (five to nine per patient) were measured by liquid chromatography on days 1 to 3. Parasitemia was counted on days 0, 1, 2, 3, 4, 7, and 14. "
08/01/2005 - "The therapeutic response to quinine treatment was comparable between patients with (CS)CM and CM. In conclusion, uniquely in this setting, CM can be associated with sub-patent parasitemia; thus, a diagnostic tool more sensitive than microscopy is needed."
08/01/2005 - "Pregnant women participating in a longitudinal immuno-epidemiologic survey in Lambaréné, Gabon, and presenting with Plasmodium falciparum parasitemia at monthly blood smear examinations were offered treatment with oral 7-day quinine monotherapy according to national health guidelines. "
03/01/1997 - "When the monkeys immunized with the antigen combination were challenged with blood-stage parasites, there was substantial protection: three of seven immunized animals self-cured and two others experienced a delayed peak of parasitemia. "
11/01/2011 - "RDT had the highest number of unique positives, presumably from persistent antigen despite the absence of parasites, although RDT did not detect 3 parasitemias with over 1,000 parasites/μl. "
10/01/2010 - "Our results indicate that antigen quantity should be studied more carefully because the sensitivity of the RDT is affected more by antigen concentration than by parasitemia."
10/01/2010 - "A large variation of antigen concentration in samples was found at same parasitemia. "
04/01/2008 - "Stimulation of the immune response by the increase of leukocytes might lead to the suppression of parasitemia in the Duffy antigen knockout mice. "
09/01/2005 - "The patient was put on benznidazole with rapid clearance of the parasitemia. "
11/01/1998 - "Treatment with benznidazole was effective in reducing parasitemia, stabilizing the clinical status, and controlling tissue damage related to the parasite. "
01/01/1998 - "Specific antitrypanosomal treatment with benznidazole was effective in reducing the level of parasitemia and improving the clinical condition in three of the four patients treated."
01/01/2014 - "LYC-loaded NC showed higher cure rates, reduced parasitemia, and increased survival when used in doses 2five times lower than those used for benznidazole. "
01/01/2014 - "Thiazolidinone 4 h was able to reduce the in vitro parasite burden and the blood parasitemia in mice with similar potency to benznidazole. "
10/15/2012 - "In addition, despite adversely affecting parasitemia and weight in non-artemether treated infected mice, HJP-272, seemed to confer some survival benefit when used as adjunctive therapy, though this did not reach significance. "
12/01/1993 - "The effects of artemether on the morphology of Plasmodium falciparum were studied in an owl monkey (Aotus trivirgatus) when parasitemia reached 33% and the animal became severely ill. "
01/01/2003 - "haematobium infections, microhematuria and macrohematuria, and the incidence of malaria parasitemia were all significantly lower in artemether recipients. "
05/06/2004 - "CF(3) analogues of artemether and arteether exhibited a high in vivo antimalarial activity on mice infected with Plasmodium berghei NK173, with a complete clearance of the parasitemia during the entire observation period (25 days)."
08/01/2007 - "Artemether-lumefantrine clears parasitemia more rapidly than ASP but both combinations are effective in treatment of uncomplicated P. "
07/01/2001 - "Individuals in the study population were drug-cured and followed up for 6 months; no significant correlation was observed between the anti-MSP4 antibodies and the absence of parasitemia during the surveillance period. "
08/01/2007 - "Previously infected monkeys with preexisting anti-MSP1(19) antibodies showed low peak parasitemias that cleared spontaneously. "
04/01/1991 - "The serum levels of transfused antibodies were low at the peak of parasitemia, suggesting that clearance of parasites was mediated by immune responses mounted by the monkeys. "
07/01/1990 - "The present study was undertaken in order to demonstrate that reinfection could modify parasitemia, serum antibodies, electrocardiographic patterns and/or myocardial lesions already observed in a rat model. "
01/01/2015 - "Lastly, this method has been successfully adapted and employed in field based research settings for parasitemia measurements in vivo, ex vivo, and in vitro and to measure invasion inhibition by antibodies and the use of alternative pathways for invasion. "
|9.||sulfadoxine-pyrimethamine (Fansidar)FDA Link
01/01/2011 - "Efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria."
01/01/2010 - "Compared to women without nets who did not receive 2-dose sulfadoxine-pyrimethamine, women using nets and receiving 2-dose sulfadoxine-pyrimethamine were less likely to have parasitemia or low birth weight babies. "
12/01/2006 - "Febrile adults with Plasmodium falciparum parasitemia were treated with sulfadoxine-pyrimethamine and were monitored for 28 days. "
09/15/2005 - "Parasitemia was defined as presence of asexual parasites on a thick film of blood and was treated with sulfadoxine/pyrimethamine (SP), in accordance with national policy. "
12/01/1981 - " In the Fansidar group, 4 of 22 patients took more than 15 days to clear the parasitemia. "
|10.||Mefloquine (Lariam)FDA LinkGeneric
11/01/1999 - "Patients who received mefloquine monotherapy and cleared parasitemia in less than 48 hours had a significantly higher AUC(0-infinity) independent of any confounders, compared with patients with slower parasite clearance (geometric mean [95% CI], 50,373 ng/mL x day [46,121 to 55,017 ng/mL x day] versus 45,583 ng/mL x day [42,306 to 49,125 ng/mL x day]). "
05/01/2011 - "All members of the control cohort but none of the mefloquine cohort developed patent parasitemia. "
05/01/1993 - "Monkeys vaccinated with either SERA 1 and Freund's, SERA 1 and MF75.2, or MF75.2 alone and that had been challenged but did not develop a countable parasitemia were treated with a curative dose of mefloquine 100 days after parasite challenge and then rechallenged 40 days later. "
11/21/1992 - " Parasites did not clear from the blood of 2 patients in the mefloquine group, although there was a decrease in parasitemia. "
09/01/1990 - "The use of lariam leads to a more rapid (as compared to the standard treatment) elimination of parasitemia and complete eradication of the disease relapses. "
10/01/1997 - "Reinfections are clinically indistinguishable from recrudescence and are more likely after treatment with rapidly eliminated drugs; we measured the incidence of parasitemia in 205 initially aparasitemic children to allow comparison with the three treatment groups. "
05/01/2014 - "The method involves numeric estimation of the relative difference in hematocrit at baseline (pretreatment) and the first 1 or 2 days after treatment begun as numerator and the corresponding relative difference in parasitemia as the denominator, and expressing it per 1000 parasites cleared from peripheral blood. "
07/01/2012 - "By 24 hours after treatment initiation, 37.0% of participants had cleared parasitemia, compared with 31.9% in 2002-2004 (P = 0.5). "
01/30/1988 - "vivax and a mean parasitemia of 13,858 +/- 10,835 per cubic millimeter were cured but 3 had a relapse 3 to 4 weeks after treatment. "
04/01/2000 - "A study of PM-SD effectiveness carried out between 1997 and 1999 at Kilifi on the Kenyan coast has shown the emergence of RI and RII resistance to PM-SD (residual parasitemia 7 days after treatment) in 39 out of 240 (16.25%) patients. "
|2.||Drug Therapy (Chemotherapy)
04/01/1998 - "Among the 27 patients who had additional complications, parasitemia levels as high as 81% responded well to chemotherapy alone. "
04/01/2010 - "In both cases, antimalarial chemotherapy was begun and erythrocytapheresis was performed, and dramatic reduction of parasitemia was achieved. "
11/01/2003 - "PCR assay for monitoring Trypanosoma cruzi parasitemia in childhood after specific chemotherapy."
01/01/1992 - "All developed detectable parasitemia after 7 to 12 days and all received drug therapy within 24 hours. "
08/01/1982 - "Drug therapy resulted in cure if it was given before the parasitemia rose to 53%. "
02/01/2009 - "Among the newly synthesized molecules, bis-oxadiazolone and bis-O-methylsulfonylamidoxime derivatives induced a complete clearance of parasitemia in mice after oral administration."
03/01/2014 - "Further in vivo assays were developed only for two of the most active molecules (22 and 24), reaching significant reductions in parasitemia levels (52 % and 77%, respectively) after their oral administration to infected mice. "
12/12/2013 - "berghei infected mice following oral administration (5 mg/kg), achieving reduction of parasitemia population by 47% on day 7. "
12/01/2012 - "Increased in vivo antimalarial activity in terms of less mean percent parasitemia was observed in infected Plasmodium berghei mice after the oral administration of all the prepared nanoparticle formulations."
03/01/2012 - "A 5-day delay in the onset of parasitemia occurred with oral administration. "
03/01/1981 - "When BSO administration was continued for 18 h (intraperitoneal injection of 4 mmol/kg every 1.5 h), parasitemias temporarily cleared. "
04/01/2000 - "A suppressive effect on the parasitemia seemed to be evident when data regarding the intraperitoneal injection of Pothomorphe umbellata extracts were analyzed. "
06/01/1992 - "In addition, intraperitoneal injection of 1 x 10(6) culture forms of 1 of the opossum isolates into C3H mice resulted in low but detectable parasitemias as early as day 6 of infection. "
02/01/1978 - "Two intraperitoneal injections of the drug at a concentration of 50 mg/kg body weight at a 1-day interval greatly reduced the parasitemia of T. "
07/01/1994 - "Blood parasitemia is eliminated in mice infected with Plasmodium chabaudi adami when they are given a single intraperitoneal injection of Taxol at 150 mg/m2. "
01/01/1980 - "Splenectomy in parasitemia, with a marked decrease in the number of circulating crisis forms. "
10/01/2011 - "On Day 133 after splenectomy, intra-erythrocytic parasites were found on light microscopic examination, and the level of parasitemia reached 0.3% on blood smear. "
05/14/1996 - "We found that crisis, the time of rapidly dropping parasitemia, was abrogated by splenectomy, indicating the role of spleen in parasite killing. "
06/01/1995 - "Splenectomy of NOD/LtSz-scid mice increased both the level and duration of parasitemia in the periphery, and it also promoted the circulation of mature sexual stage parasites (gametocytes). "
12/01/1992 - "In the infected dogs without splenectomy, more prominent reduction in RBC count accompanied with the elevated AEMAL was presented than anticipated from parasitemia until the 21st day. "