Right Ventricular Dysfunction

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240 relevant articles (11 outcomes, 17 trials/studies) found for this Disease

Description: A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.

Also Known As:

Ventricular Dysfunction, Right; Dysfunction, Right Ventricular; Dysfunctions, Right Ventricular; Right Ventricular Dysfunctions; Ventricular Dysfunctions, Right

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18525

Heart Diseases: 12357

Ventricular Dysfunction: 583

Right Ventricular Dysfunction: 240

Related Diseases

1.	Pulmonary Hypertension (Ayerza Syndrome)
2.	Shock
3.	Pulmonary Embolism
4.	Myocardial Infarction
5.	Hemorrhage

Experts

1.	Tulevski, I I: 2 articles (11/2001 - 07/2001)
2.	Hirsch, A: 2 articles (11/2001 - 07/2001)
3.	van Veldhuisen, D J: 2 articles (11/2001 - 07/2001)
4.	Mulder, B J: 2 articles (11/2001 - 07/2001)
5.	Baydin, A: 1 article (08/2008)
6.	Yardan, T: 1 article (08/2008)
7.	Guven, H: 1 article (08/2008)
8.	Yilmaz, O: 1 article (08/2008)
9.	Altintop, L: 1 article (08/2008)
10.	Della Corte, A: 1 article (07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Right Ventricular Dysfunction:

1.	Fibrinolytic Agents (Antithrombotic Agents)IBA 12/01/2002 - "Recent studies suggest the use of thrombolytic drugs in patients with normal systemic blood pressure who show right ventricular dysfunction at echocardiographic examination" 09/01/2008 - "SUMMARY: Current evidence does not support the use of thrombolytic agents in most hemodynamically stable patients with right ventricular dysfunction" 12/01/1999 - "Recent reports have suggested that thrombolytic agents could be clinically useful in a subgroup who have right ventricular dysfunction on echocardiography" 05/01/1994 - "The use of thrombolytic agents has decreased the incidence of right ventricular dysfunction after acute myocardial infarction" 09/01/2001 - "OBJECTIVE: The indications for the use of thrombolytic agents in massive pulmonary embolism (MPE) remain controversial and it has been suggested that transthoracic echocardiographic (TTE) examination, which is able to detect an associated right ventricular dysfunction, may cast light on this question" Order ALL the reference details at left...
2.	Heparin (Liquaemin)FDA LinkGeneric 12/01/2000 - "If there is no right ventricular dysfunction a treatment with heparin is indicated" 02/27/1993 - "Data from a non-randomised study have hinted that in patients with acute pulmonary embolism (PE), thrombolysis followed by heparin more rapidly reverses right-ventricular dysfunction and restores pulmonary tissue perfusion than does heparin alone" 05/01/2004 - "The combined with antithrombotic therapy using heparin sodium, was successfully treated the patient from cardiogenic shock due to APE with right ventricular dysfunction after cesarean section." 10/01/2005 - "In normotensive patients with right ventricular dysfunction at echocardiography, who represent about 30% of PE patients, the debate regarding the optimal therapy is still open and further studies are required to document a clinically relevant improvement in the benefit-risk ratio of thrombolytic agents over heparin alone: young people, with a very low risk of bleeding and a concomitant reduction of cardiopulmonary reserve might be the best candidates to systemic thrombolysis" 01/08/2007 - "METHODS: We performed a cost-effectiveness analysis to compare health effects and costs of treatment with alteplase plus heparin sodium vs heparin alone in hemodynamically stable patients with pulmonary embolism and right ventricular dysfunction by developing a Markov model and using data from clinical trials and administrative sources" Order ALL the reference details at left...
3.	Norepinephrine (Noradrenaline)FDA LinkGeneric 06/01/1989 - "The data suggested that in this model of right ventricular dysfunction, norepinephrine consistently improved myocardial performance without provoking further vasoconstriction in either the pulmonary or renal circulations." 03/01/2000 - "Hyperdynamic septic shock with decreased vascular resistance is treated with norepinephrine to restore mean arterial pressure and to improve right ventricular dysfunction induced by pulmonary hypertension." 01/01/1987 - "Volume expansion, dobutamine and noradrenaline for treatment of right ventricular dysfunction in porcine septic shock: a combined invasive and radionuclide study." Order ALL the reference details at left...
4.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/1998 - "Value of nitric oxide (NO) in neonatal right ventricular dysfunction]" 11/04/1997 - "Nitric oxide inhalation in the treatment of right ventricular dysfunction following left ventricular assist device implantation." 10/01/2006 - "We report the use of inhaled nitric oxide in a patient with acute right-ventricular dysfunction after extrapleural pneumonectomy." 10/01/2006 - "Inhaled nitric oxide for acute right-ventricular dysfunction after extrapleural pneumonectomy." 01/01/1997 - "Inhaled nitric oxide for right ventricular dysfunction following cardiac transplantation." Order ALL the reference details at left...
5.	OxygenIBA 10/01/2006 - "Postoperative right ventricular dysfunction may be characterized by elevated right atrial pressure and decreased systemic oxygen saturation owing to right-to-left shunting at the atrial level" 02/01/2000 - "Supplemental oxygen may also improve right ventricular dysfunction in patients with underlying right ventricular dysfunction" 05/01/1985 - "100) throughout exercise and at maximal effort: this corresponds to a lower stroke volume secondary to the absence of physical activity during childhood and/or residual cardiac lesions; abnormal chronotropism: the test was stopped at a lower heart rate corresponding to a fall in oxygen uptake during exercise, or to an increase in the systolic ejection period probably due to right ventricular dysfunction or to the patient reaching maximal ventilation; decreased maximal ventilation capacity due to a lower tidal volume and a higher respiratory rate" 05/01/1996 - "In conclusion, right ventricular dysfunction is common in obstructive sleep apnoea, but it is reversible with nasal continuous positive airway pressure treatment and appears to be related to nocturnal oxygen desaturation." 11/01/2006 - "Impact of pulmonary regurgitation and right ventricular dysfunction on oxygen uptake recovery kinetics in repaired tetralogy of Fallot." Order ALL the reference details at left...
6.	sildenafil (Viagra)FDA Link 07/01/2008 - "Role of sildenafil in acute posttransplant right ventricular dysfunction: successful experience in 13 consecutive patients." 06/01/2005 - "We report the use of oral sildenafil in a patient with severe secondary pulmonary hypertension and right ventricular dysfunction" 07/01/2004 - "Potential role for sildenafil in the management of perioperative pulmonary hypertension and right ventricular dysfunction after cardiac surgery." 07/01/2008 - "CONCLUSION: Management of acute right ventricular dysfunction in heart transplant recipients with pulmonary hypertension using sildenafil proved safe and effective." 07/01/2008 - "METHODS: Herein we have presented a series of 13 patients in whom sildenafil was used to treat right ventricular dysfunction and pulmonary hypertension as detected by transesophageal echocardiography and Swan-Ganz right heart catheterization after heart transplant" Order ALL the reference details at left...
7.	simendan (Levosimendan)IBA 03/01/2007 - "CONCLUSIONS: In an experimental model of acute right ventricular dysfunction, levosimendan improved global hemodynamics and optimized right ventriculovascular coupling via a moderate increase in right ventricular contractility and a mild reduction of right ventricular afterload." 03/01/2007 - "OBJECTIVE: Experimental data suggest that levosimendan has pulmonary vasodilatory properties which, in combination with its positive inotropic effects, would render it particularly attractive for the treatment of right ventricular dysfunction" 03/01/2007 - "Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction." 02/01/2008 - "Levosimendan may also be useful during right ventricular dysfunction and septic shock due to its favorable effects on splanchnic perfusion" 02/01/2008 - "In addition, further possible indications for levosimendan have been described, such as perioperative use, cardioprotection, cardiogenic shock, sepsis, and right ventricular dysfunction" Order ALL the reference details at left...
8.	Endothelin Receptors (Endothelin Receptor)IBA 09/01/2007 - "While long-term oxygen therapy in patients with COPD and cor pulmonale and for example the administration of endothelin receptor antagonists in patients with idiopathic pulmonary hypertension is beneficial, the therapeutic use of drugs effective for left-sided heart failure is very limited in patients with right ventricular dysfunction." Order ALL the reference details at left...
9.	Streptokinase FDA Link 12/01/2001 - "In 35 patients high dose and short-term streptokinase regimen reversed acute pulmonary arterial hypertension, clinical and echocardiographic evidence of right ventricular dysfunction and improved pulmonary perfusion without increasing hemorrhagic complications" 12/01/2001 - "The primary end point was efficacy and safety of streptokinase regimen in terms of pulmonary arterial hypertension, right ventricular dysfunction, perfusion abnormalities, recurrence, mortality and hemorrhagic complications" Order ALL the reference details at left...
10.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 05/01/2007 - "The growing use of low molecular weight heparin has also improved and facilitated the therapeutic management of pulmonary embolism while indication of fibrinolysis in presence of right ventricular dysfunction, but without shock, remains controversial." Order ALL the reference details at left...

Therapies and Procedures

1.	Thrombolytic Therapy 11/01/1994 - "A recent study described a subset of hemodynamically stable patients with right-ventricular dysfunction who also might benefit from thrombolytic therapy." 01/01/2009 - "With proper risk assessment, select patients with stable hemodynamics and right ventricular dysfunction may also benefit from fibrinolytic therapy" 01/01/2002 - "Thrombolytic therapy can be considered for patients with hemodynamic instability, those with right ventricular dysfunction, and young patients with a massive PE despite a normal right ventricle on echocardiography" 03/01/2000 - "Furthermore, the expanded application of thrombolytic therapy to patients with PE and right ventricular dysfunction (RVD) but without overt hemodynamic collapse remains controversial" 01/01/1998 - "Among patients with right ventricular dysfunction, thrombolytic therapy is being used more often because this strategy may improve overall prognosis" Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 06/01/1995 - "Only the right lung could be incorporated into the cardiopulmonary circulation at transplantation, resulting in transient right ventricular dysfunction, which resolved with vasodilator therapy" 07/01/1990 - "Radionuclide ventriculography performed early after transplantation can identify patients both with abnormal biventricular function resulting from preservation injury and with isolated right ventricular dysfunction" 04/01/1990 - "The high prevalence of RBBB morphology in heart transplant recipients appears to be related to posterior rotation of the long axis of the heart in the transverse plane, probably resulting from the surgical technique, and to right ventricular dysfunction." 09/01/2008 - "Early graft failure, particularly right ventricular dysfunction, remains a significant determinant of early morbidity and mortality in heart transplant recipients" 09/01/1996 - "Unlike transplantation candidates, patients with pulmonary hypertension (PHTN) and a high transpulmonary gradient do not appear to be at increased risk for right ventricular dysfunction after left ventricular assist system implant" Order ALL the reference details at left...
3.	Lung Transplantation 07/01/1992 - "Experience with single-lung transplantation for other conditions suggested that associated severe right ventricular dysfunction resulting from increased afterload would recover after placement of a satisfactory lung allograft" 05/01/2006 - "BACKGROUND: Some lung transplantation (LT) recipients suffer from pulmonary hypertension and right ventricular dysfunction or failure requiring extracorporeal circulation (ECC) to avoid catastrophic complications during surgery" 12/01/1991 - "CONCLUSION--In patients with moderate pulmonary hypertension and right ventricular dysfunction secondary to end stage fibrosing lung disease single lung transplantation was followed by an improvement in pulmonary haemodynamic variables and right ventricular function." Order ALL the reference details at left...
4.	Counterpulsation (External Counterpulsation) 07/01/1987 - "The present study compared the effectiveness of pulmonary artery balloon counterpulsation with a right ventricular assist device for support of surgically induced right ventricular dysfunction" 08/01/1995 - "Intraaortic and pulmonary artery counterpulsation are useful techniques to support circulation during either left or right ventricular dysfunction" 06/01/1989 - "Nursing implication for pulmonary artery balloon counterpulsation: a treatment for right ventricular dysfunction after cardiac surgery." 11/01/2000 - "Considering right and left ventricular interdependence, we investigated whether intraaortic balloon counterpulsation (IABP) might also alleviate predominantly right ventricular dysfunction after heart transplantation" 01/01/1986 - "Balloon counterpulsation in the pulmonary artery in a case of severe right ventricular dysfunction after extracorporeal circulation]" Order ALL the reference details at left...
5.	Resuscitation 07/01/1989 - "The present experimental study demonstrated the retrograde cardioplegic method could produce right ventricular perfusion resulting in right ventricular dysfunction early after cardiac resuscitation" 11/01/2002 - "Among controls, right ventricular dysfunction post-resuscitation was demonstrated by a decrease in right ventricular ejection fraction and an increase in right ventricular end-diastolic pressure" 11/01/2002 - "Dobutamine can ameliorate post-resuscitation right ventricular dysfunction." 11/01/2002 - "Post-resuscitation right ventricular dysfunction: delineation and treatment with dobutamine." 03/01/1980 - "All patients increased their CO in response in fluid resuscitation, but six patients with an elevated mean pulmonary artery pressure (greater than 20 mmHG and increased pulmonary vascular resistance (greater than 1.2 mmHg/min/L) had right ventricular dysfunction as evidenced by an increase (188 +/- 15 ml/M2) in RVEDVI and a decreased (0.26 +/- 4 ml/M2) RVEF" Order ALL the reference details at left...

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