|4.||Acute Lung Injury
|1.||O'Reilly, Michael A: 24 articles (01/2015 - 10/2002)|
|2.||Welty, Stephen E: 22 articles (11/2015 - 03/2002)|
|3.||Moorthy, Bhagavatula: 19 articles (11/2015 - 03/2002)|
|4.||Bhandari, Vineet: 19 articles (08/2015 - 07/2002)|
|5.||Xu, Feng: 19 articles (02/2015 - 10/2004)|
|6.||Kleeberger, Steven R: 18 articles (11/2015 - 01/2002)|
|7.||Choi, Augustine M K: 17 articles (04/2013 - 03/2003)|
|8.||Martin, Richard J: 16 articles (10/2015 - 05/2004)|
|9.||Jiang, Weiwu: 15 articles (11/2015 - 08/2004)|
|10.||Xue, Xin-Dong: 14 articles (10/2015 - 02/2006)|
04/01/1991 - "We propose that the ability to increase CuZnSOD activity is the most important factor of the enzymatic oxygen free radical defense system for protection against hyperoxia-induced lung damage detected by MRI. "
01/01/2013 - "While eubaric hyperoxia has been beneficial in experimental studies, clinical brain oxygen protocols incorporating intracranial pressure control, maintenance of cerebral perfusion pressure, and the effective use of fraction of inspired oxygen adjustments to maintain cerebral oxygenation levels >20 to 25 mmHg have demonstrated mortality reductions and improved clinical outcomes. "
09/01/2009 - "In the 6 studies, high-concentration oxygen therapy resulted in hyperoxia, with a range in mean Pao(2) of 273 to 425 mm Hg. Hyperoxia caused a significant reduction in coronary blood flow (mean change -7.9% to -28.9%, n = 6 studies). "
01/01/2015 - "Short-term exposure to 100% oxygen in the acute post-traumatic phase significantly attenuated systemic and local inflammatory responses and improved fracture healing without provoking toxic side effects, suggesting that hyperoxia could induce anti-inflammatory and pro-regenerative effects after severe injury. "
01/01/2007 - "Administered hyperoxia has been shown to be effective as a blood oxygenation level-dependent contrast agent for magnetic resonance imaging (MRI); however, it is known that high levels of inspired fraction of oxygen result in regionally decreased perfusion in the brain potentially confounding the possibility of using hyperoxia as a means of measuring blood flow and volume. "
|2.||Dexamethasone (Maxidex)FDA LinkGeneric
03/01/1997 - "In preterm animals, prenatal dexamethasone administration does not show any of the hypothesized protective effects against hyperoxia or protective biochemical lung changes during prolonged O2 exposure. "
03/01/2008 - "Combined pretreatment by hyperoxia and dexamethasone improved postischemic heart function, but did not reduce infarct size compared to single pretreatment groups. "
03/01/2008 - "Combined pretreatment improved postischemic left ventricular end diastolic pressure compared to all other groups (p<0.001 vs controls, p=0.002 vs dexamethasone, p=0.005 vs hyperoxia). "
02/01/1980 - "Despite this growth inhibition, the dexamethasone-treated pups had improved survival in hyperoxia (36/48 = 75% vs 29/48 = 60% for untreated rats, P = .055). "
04/01/2006 - "This study aimed to explore the effects of hyperoxia on the development of fetal lung by investigating the changes of morphological and cell proliferation induced by hyperoxia in cultured fetal lungs as well as the effects of dexamethasone on hyperoxia-exposed lungs. "
|3.||Glutathione (Reduced Glutathione)IBA
09/01/1999 - "Survival of guinea pig pups in hyperoxia is improved by enhanced nutritional substrate availability for glutathione production."
02/15/1985 - "Protection against lethal hyperoxia by tracheal insufflation of erythrocytes: role of red cell glutathione."
05/15/2005 - "Although many cellular components are potential targets, our studies indicate that mitochondrial glutathione is particularly vulnerable to hyperoxia damage. "
01/01/1988 - "Studies with endothelial cell cultures exposed to hyperoxia showed elevation of cellular glutathione coupled with enhanced uptake of amino acid precursors of glutathione. "
11/01/2013 - "The results demonstrated that exogenous Ad protected against the hyperoxia-induced oxidative stress, loss of glutathione (GSH), cytoskeletal reorganization, barrier dysfunction, and leak in the lung ECs in vitro. "
07/01/2010 - "Further, MTF-1 overexpression in a neuron-specific manner protects flies against hyperoxia and prolongs the life-span of Cu/Zn superoxide dismutase-deficient flies, suggesting the presence of a common mechanism for protection against both oxidative stress and metal toxicity. "
01/01/1988 - "Protection against hyperoxia by serum from endotoxin treated rats: absence of superoxide dismutase induction."
01/01/1983 - "Superoxide dismutase provides protection against the hyperoxia in the retina of the rainbow trout (Salmo gairdneri)."
08/01/2012 - "Superoxide dismutase activity decreased in all groups exposed to hyperoxia (P < 0.01). "
03/01/2012 - "Transgenic (TG) mice (with an extra copy of the human extracellular superoxide dismutase gene) and wild-type (WT) neonate mice were exposed to hyperoxia (95% of F(i) o(2) ) for 7 days after birth versus the control group in room air. "
08/01/1984 - "Despite increases in these protective antioxidant enzymes which persist in 2.0 ATA O2 (4 h) and 4.0 ATA O2 (1.0 h), such rats do not have improved survival in hyperbaric hyperoxia. "
05/01/2011 - "In this study, we demonstrated gender-related effect of hyperoxia on oxidant/antioxidant status and on expression of certain P450 enzymes. "
06/02/2009 - "Although further studies are needed to clarify the mechanisms of ischemic tolerance, the intermittent and prolonged normobaric hyperoxia seems to partly exert their effects via increase antioxidant enzymes activities."
01/01/2000 - "Previous studies have shown increased activities of antioxidant enzymes (AOE) in lung tissue from animals exposed to hyperoxia. "
05/01/1976 - "In studies directed at determining the activities of selected enzymes in lung tissue after in vivo exposure to hyperoxia, 70-day-old rats were exposed to 85% or 90% O2 for 1-14 days. "
|6.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/01/2010 - "After antenatal ETX, moderate hyperoxia increased lung VEGF and VEGFR-2 protein contents in ETX-O₂ rats and improved their alveolar and vascular structure and RVH compared with ETX-RA rats. "
10/01/2007 - "The aim of this study was to investigate the changes of VEGF and eNOS expression in the lungs of premature rats exposed to moderate hyperoxia in order to explore possible relationships with BPD. "
06/01/2015 - "This vasoprotective effect was independent of enhanced circulating vascular endothelial growth factor (VEGF), which was reduced by hyperoxia, but to local retinal ganglion cell layer-derived VEGF. "
06/01/2015 - "Hyperoxia exposure led to air space enlargement, loss of lung capillaries, and low expression of VEGF and eNOS. "
02/20/2015 - "The concentration of VEGF was significantly decreased on P9 but increased on P14 in the retinas of pups exposed to hyperoxia, whereas it was significantly elevated on P9 but decreased on P14 in the retinas of pups treated with 17β-E2. "
12/01/2013 - "Conversely, disruption of endogenous catalase activity using a UAS-CatRNAi transposon resulted in an enhanced hyperoxia-aversive response. "
12/01/2013 - "Degradation of endogenous H2O2 by transgenic overexpression of catalase in larval epidermis caused a suppression of hyperoxia aversion behavior. "
09/15/2011 - "We propose that H(2)O(2) generated by PPHN and hyperoxia inactivates ecSOD, and intratracheal catalase enhances enzyme function. "
12/31/2010 - "Mitochondrially targeted catalase decreased PDE5 activity at baseline and after hyperoxia in PPHN PASMC. "
11/01/2002 - "This suggests that SOD and catalase do not play a role in the adaptive response against oxidative stress under hyperoxia, at least under these experimental conditions."
|8.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/01/2005 - "Thus we conclude that TNFalpha, acting through TNFRI, appears important for the protective effects of hyperoxia."
11/01/2007 - "Compared to air exposure groups, the levels of TNFalpha and TGFbeta1 in the homogenate of the lungs increased while RACs decreased significantly in the two hyperoxia exposure groups. "
05/01/2005 - "Role of tumor necrosis factor alpha and its receptor I in preconditioning by hyperoxia."
01/01/2005 - "We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates the caspase cascade in type II pneumocytes (TIIcells). "
03/01/2004 - "Because the signal transduction mechanisms induced by IL-1beta are distinct to that of TNF-alpha, herein we sought to determine whether hyperoxia modulates IL-1beta-dependent signal transduction. "
10/01/2004 - "This work assessed the hypotheses that (1) hyperoxia is preferable to air breathing during retinal arterial occlusion, (2) hyperoxia during occlusion is beneficial in promoting recovery from arterial occlusion, and (3) hyperoxia has value even if it is delayed relative to the onset of the occlusion. "
04/01/2014 - "Our data show that the supplement used in the present study can normalize the response of retinal RBC flow to hyperoxia under LPS administration. "
04/01/2014 - "On each study day, retinal red blood cell (RBC) flow and the reactivity of retinal RBC flow to hyperoxia were investigated in the absence and presence of 2 ng/kg LPS. "
09/01/2012 - "The purpose of the study was to examine the association between retinal flickering light-induced vasodilation and retinal hyperoxia-induced vasoconstriction in type 2 diabetic subjects and in healthy controls. "
09/01/2012 - "Previous studies have demonstrated that retinal flickering light-induced vasodilation and hyperoxia-induced vasoconstriction may operate by enhancing or reducing similar vasoregulatory factor(s), but a comparison between these two provocative stimuli in individuals with diabetes has not been studied. "
|10.||Reactive Oxygen Species (Oxygen Radicals)IBA
12/01/2006 - "These results suggest that the MCP-1/CCR2 signalling pathway is protective against hyperoxia-induced tissue injury by suppressing induction of iNOS and consequent production of reactive oxygen species by activated alveolar macrophages."
12/01/2012 - "In the period pre-CPB, hyperoxia may precondition the myocardium and, paradoxically, confer a degree of protection against reactive oxygen species-induced injury at the time of reperfusion. "
01/01/2015 - "However, hyperoxia may affect tissue responses, particularly in studies which involve reactive oxygen species (ROS). "
01/01/2011 - "Studies including ours have shown that reactive oxygen species (ROS), generated by exposure to prolonged hyperoxia, can cause a decrease in the phagocytic activity of alveolar macrophages. "
02/29/2008 - "In this study, we tested the hypothesis that hyperoxia elicits this plasticity through the increased production of reactive oxygen species (ROS). "
12/01/2015 - "In our model, fully automated FiO2 control was feasible in rapidly changing physiologic conditions during postnatal resuscitation and prevented hyperoxia. "
12/01/2015 - "Time within target range did not differ significantly between manual and automated FiO2 control during resuscitation, however automated FiO2 control significantly avoided hyperoxia. "
12/01/2012 - "Arterial hyperoxia after resuscitation has been associated with increased mortality in adults. "
11/01/2012 - "The effect of short-term hyperoxia on the newborn pulmonary vasculature is unknown but is, however, of clinical significance in the neonatal resuscitation context. "
07/17/2012 - "Extrapolating from adult data, current pediatric resuscitation guidelines recommend avoiding hyperoxia. "
08/10/2012 - "The results of trials of hyperbaric oxygenation (HBO) have failed to show a benefit, but renewed interest in normobaric hyperoxia (NBO) in the treatment of TBI patients has emerged in recent years. "
11/01/2008 - "Hyperoxia, induced by a clinically relevant hyperbaric oxygen therapy (HBO) protocol, can significantly enhance the mobilization of EPCs from the BM into peripheral blood. "
01/01/2008 - "Exposure to hyperbaric hyperoxia during hyperbaric oxygen therapy may affect cardiovascular functions by different mechanisms. "
09/01/1999 - "We review the use of hyperbaric oxygen therapy in urology, and present the mechanisms of hyperoxia action in whole body hyperbaric chamber treatments, patient outcomes and patient selection criteria. "
03/01/1999 - "In adult animals initially subjected to hyperbaric oxygenation at the same stage of development but at the pressure--0.7 MPa, the second exposure to hyperoxia led to a drastic intensification of lipid peroxidation in the brain; in some animals, an increased level of lipid peroxidation products in the lungs was observed."
|3.||Artificial Respiration (Mechanical Ventilation)
02/01/2007 - "Reports of interaction effects between hyperoxia and both mechanical ventilation and host defense suggest that clinical studies of hyperoxia must take these variables into account. "
01/01/2015 - "Mechanical ventilation of Src-deficient mice with hyperoxia further reduced the activation of Smad3. "
11/01/2014 - "TREK-1 deficiency resulted in increased sensitivity of lungs to hyperoxia, but this effect is less prominent if overwhelming injury is induced by the combination of hyperoxia and injurious mechanical ventilation. "
11/01/2014 - "Mice were anesthetized and exposed to 1) room air, no mechanical ventilation, 2) 95% hyperoxia for 24 hours, and 3) 95% hyperoxia for 24 hours followed by mechanical ventilation for 4 hours. "
03/01/2014 - "Hyperoxia and the mechanical load imposed by positive pressure mechanical ventilation disrupt these paracrine interactions, leaving thickened alveolar walls, airways and arterioles, thereby diminishing gas-exchange surface area. "
02/01/2012 - "The positive results of 2 subgroup analyses (general anesthesia and colorectal surgery trials) suggest a benefit for hyperoxia in decreasing surgical site infection. "
03/01/2014 - "Although the precise cause of encephalopathy cannot be determined, it is important to consider the role that SBP hypotension (as well as hypoglycemia, hyperthermia, hyperoxia, and hypocapnia) plays during general anesthesia in young infants in the development of infantile postoperative encephalopathy. "
04/21/1997 - "In this study, we studied the in vitro effects of hyperoxia on the release of proinflammatory cytokines and the expression of surface receptors in AM obtained from cynomolgus monkeys by bronchoalveolar lavage under general anesthesia. "
01/01/2015 - "To evaluate laser speckle flowgraphy (LSFG) measurements of the optic nerve head (ONH) blood flow (BF) response to hyperoxia. "
04/04/2014 - "Using two-photon laser scanning microscopy (TPLSM), the changes in cortical microvasculature were measured during normoxia and hyperoxia. "
04/04/2014 - "Using laser-Doppler flowmetry (LDF), baseline cerebral blood flow (CBF) and the cerebrovascular responses to whisker stimulation were measured in awake mice during normoxia and hyperoxia. "
07/01/2013 - "In 30 healthy young men indicators of microcirculation and tissue oxygenation (laser Doppler flowmetry, and the optical tissue oximetry) during the hypoxic test - HT (10 min breathing by gas mixture with 10% O2 followed by hyperoxia (30% O2) were registered. "
06/01/2007 - "We addressed these issues using real-time two-dimensional multispectral reflectance imaging and laser speckle flowmetry to simultaneously and non-invasively determine the impact of normobaric hyperoxia on CBF and oxygenation in ischaemic cortex. "