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Protein S Deficiency (Deficiency, Protein S)

An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Also Known As:
Deficiency, Protein S; Deficiencies, Protein S; Protein S Deficiencies
Networked: 693 relevant articles (5 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Thrombosis (Thrombus)
2. Necrosis
3. Thrombophilia
4. Antithrombin III Deficiency
5. Protein C Deficiency

Experts

1. Nowak-Göttl, Ulrike: 6 articles (01/2013 - 01/2002)
2. Martinelli, Ida: 5 articles (11/2013 - 05/2002)
3. Rosing, Jan: 5 articles (09/2010 - 07/2002)
4. Hackeng, Tilman M: 5 articles (09/2010 - 12/2004)
5. van der Meer, Jan: 5 articles (05/2009 - 07/2002)
6. Bucciarelli, Paolo: 4 articles (11/2013 - 08/2004)
7. Junker, Ralf: 4 articles (08/2012 - 01/2002)
8. Pabinger, I: 4 articles (02/2012 - 03/2005)
9. Rosendaal, F R: 4 articles (02/2012 - 01/2000)
10. Borrell, Montserrat: 4 articles (01/2011 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Protein S Deficiency:
1. Protein CIBA
2. Protein SIBA
3. Antithrombin IIIIBA
4. Warfarin (Coumadin)FDA LinkGeneric
5. ThrombinFDA Link
6. Heparin (Liquaemin)FDA LinkGeneric
7. Vitamin KFDA Link
8. Tissue Plasminogen Activator (Alteplase)FDA Link
9. Complement C4b-Binding ProteinIBA
10. Proteins (Proteins, Gene)IBA

Therapies and Procedures

1. Catheters
2. Stents
3. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4. Transplants (Transplant)
5. Cesarean Section (Caesarean Section)