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Middle Ear Cholesteatoma

A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR.
Also Known As:
Cholesteatoma, Middle Ear; Aural Cholesteatoma; Aural Cholesteatomas; Cholesteatoma, Aural; Cholesteatomas, Aural; Cholesteatomas, Middle Ear; Middle Ear Cholesteatomas
Networked: 312 relevant articles (3 outcomes, 62 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Cholesteatoma
2. Pathologic Constriction (Stenosis)
3. Bone Resorption
4. Suppurative Otitis Media
5. Otitis Media

Experts

1. Yamamoto-Fukuda, Tomomi: 8 articles (01/2021 - 01/2003)
2. Liu, Wei: 7 articles (12/2021 - 01/2014)
3. Ren, Jihao: 7 articles (12/2021 - 01/2014)
4. Xie, Shumin: 7 articles (12/2021 - 01/2014)
5. Akiyama, Naotaro: 6 articles (01/2021 - 11/2014)
6. Choung, Yun-Hoon: 6 articles (01/2019 - 01/2003)
7. Kojima, Hiromi: 5 articles (12/2022 - 01/2013)
8. Yin, Tuanfang: 5 articles (12/2021 - 01/2014)
9. Park, Keehyun: 5 articles (03/2014 - 01/2003)
10. Hwang, Soon-Jae: 5 articles (10/2009 - 09/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Middle Ear Cholesteatoma:
1. Durapatite (Hydroxylapatite)IBA
2. Keratins (Keratin)IBA
3. ErbB Receptors (EGF Receptor)IBA
4. EnzymesIBA
5. Proteins (Proteins, Gene)FDA Link
6. Monoclonal AntibodiesIBA
7. DNA (Deoxyribonucleic Acid)IBA
8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
9. Epidermal Growth Factor (EGF)IBA
10. Transforming Growth Factor alpha (TGF-alpha)IBA

Therapies and Procedures

1. Tympanoplasty
2. Mastoidectomy
3. Prostheses and Implants (Prosthesis)
4. Solid-State Lasers
5. Middle Ear Ventilation (Tympanostomy)
09/01/1990 - "Of the 30 ears in the study, 20 (66.6%) developed middle ear cholesteatoma--a rate of occurrence comparable to that found in earlier studies in which middle ear ventilation was not provided. "
05/07/2017 - "Conclusions: There may be a relationship between cleft palate associated with middle ear cholesteatoma and no grommet insertion history. "
02/01/2020 - "Middle ear cholesteatoma surgeries were divided into four types and two special types as follows: type I, attic retraction pocket, which only requires tympanostomy tube placement or retraction pocket resection and cartilage reconstruction; type II, cholesteatoma which is limited to the attic or in which endoscopy can confirm complete removal of mastoid cholesteatoma lesions, including type II a, requiring only use of a curette, and type II b, requiring use of an electric drill or chisel; type III, cholesteatoma not limited to the attic, in which endoscopy cannot confirm complete removal of mastoid cholesteatoma lesions, requiring the combined use of endoscope and microscope to perform endoscopic tympanoplasty and "Canal Wall Up" mastoidectomy; type IV, extensive involvement of mastoid cavity cholesteatoma lesions and/or cases with a potential risk of complications, removal of which can only be performed under a microscope for "Canal Wall Down" mastoidectomy. "
12/01/2022 - "Children with achondroplasia also had higher risks for diagnosed otitis media (RR: 2.21), tympanic membrane retraction (RR: 7.29), middle ear cholesteatoma (RR: 6.35), cleft palate (RR: 12.24), conductive hearing loss (RR: 12.15), and tympanostomy tube placement (RR: 9.71). "