Middle Ear Cholesteatoma

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152 relevant articles (2 outcomes, 34 trials/studies) found for this Disease

Description: A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR.

Also Known As:

Cholesteatoma, Middle Ear; Aural Cholesteatoma; Aural Cholesteatomas; Cholesteatoma, Aural; Cholesteatomas, Aural; Cholesteatomas, Middle Ear; Middle Ear Cholesteatomas

Relationship Network

Disease Context: Research Results

Otorhinolaryngologic Diseases: 123

Ear Diseases: 115

Middle Ear Cholesteatoma: 152

Skin and Connective Tissue Diseases

Skin Diseases: 5944

Keratosis: 1109

Cholesteatoma: 924

Middle Ear Cholesteatoma: 152

Related Diseases

1.	Cholesteatoma
2.	Bone Resorption
3.	Cysts
4.	Atelectasis
5.	Wounds and Injuries (Trauma)

Experts

1.	Hwang, Soon-Jae: 3 articles (06/2008 - 09/2006)
2.	Choung, Yun-Hoon: 3 articles (02/2006 - 01/2003)
3.	Park, Keehyun: 3 articles (02/2006 - 01/2003)
4.	Kodera, K: 3 articles (12/2001 - 07/2001)
5.	Iino, Y: 3 articles (12/2001 - 07/2001)
6.	Chae, Sung-Won: 2 articles (06/2008 - 03/2007)
7.	Cho, Jae-Gu: 2 articles (06/2008 - 09/2006)
8.	Lee, Heung-Man: 2 articles (03/2007 - 09/2006)
9.	Woo, Jeong-Su: 2 articles (03/2007 - 09/2006)
10.	Moon, Sung-Kyun: 2 articles (12/2005 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Middle Ear Cholesteatoma:

1.	Durapatite (Hydroxylapatite)IBA 06/01/1991 - "Hydroxyapatite granules were employed for mastoid obliteration in cases of aural cholesteatoma" 06/01/1991 - "Tympanoplasty with mastoid obliteration using hydroxyapatite granules for aural cholesteatoma--a clinical and experimental study]" 01/01/2001 - "CONCLUSION: If the tympanic and posterior cavities are reasonably safe, middle ear cholesteatoma in adults can be well cured by a one-stage procedure including ossicular chain reconstruction with hydroxylapatite prosthesis covered with cartilage graft who achieved a valuable hearing restoration." Order ALL the reference details at left...
2.	Keratins (Keratin)IBA 02/01/1994 - "Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study." 01/01/1989 - "An immunocytochemical study of cytokeratin expression in human middle ear cholesteatoma." 01/01/2003 - "Middle ear cholesteatoma is characterized by the presence in the middle ear cavity of a stratified squamous epithelium with keratin deposits which by constant proliferation leads to extensive bone destruction" 01/01/2001 - "BACKGROUND: Aural cholesteatomas are enlarging accumulations of keratin debris caused by keratinizing squamous epithelium in the middle ear" 01/01/1999 - "Using immunohistochemical method, the distribution of cytokeratin and the binding patterns of lectin were observed to show the biologic and morphologic changes that take place in aural cholesteatomas" Order ALL the reference details at left...
3.	Monoclonal AntibodiesIBA 01/01/1999 - "Through immunohistochemistry (using 18 monoclonal antibodies) on 10 specimens from human middle ear cholesteatomas, T-helper cells mixed with plasma cells, macrophages and scattered T-suppressor and B cells, have been detected in the perimatrix" 01/01/1992 - "Since a heavy cellular infiltrate is seen in the stroma of most aural cholesteatomas, we attempted to characterize this cell population in more detail using monocyte/macrophage-specific monoclonal antibodies" 01/01/1985 - "By using monoclonal antibodies against cell-membrane receptors the cellular composition of an aural cholesteatoma can be determined" 03/01/1992 - "In the present study we tried to characterize the immunophenotype and the functional state of the cells infiltrating the stroma and the epithelial layer of aural cholesteatoma, using a panel of monoclonal antibodies directed against cell type specific antigens" 07/01/1994 - "Because middle ear cholesteatoma is characterized by the presence of leukocyte infiltrates, the presence of the two molecule types of intercellular adhesion molecules (ICAM-1 and ICAM-2) was investigated on cholesteatoma using monoclonal antibodies" Order ALL the reference details at left...
4.	DNA (Deoxyribonucleic Acid)IBA 10/01/2000 - "METHOD: PCR and nuclear acid hybridization were applied in screening 44 cases of middle ear cholesteatoma for detection of HPV DNA, and a comparison analysis with the pathological results of 35 cases of middle ear cholesteatoma was made" 08/01/1991 - "Thirteen smears of middle ear cholesteatomas were investigated by the recently developed interactive DNA cytometry" 01/01/1988 - "Quantitative DNA cytophotometric techniques were applied to judge the alteration (differentiation) and ultimate fate of nuclei during keratinization in human middle ear cholesteatoma" 06/01/1994 - "Recent studies have demonstrated that aural cholesteatoma features intense DNA turnover in the germinative layer of the matrix and an immune response in the wall of the cyst, which trigger a chain reaction" 01/01/2000 - "The presence of human papillomavirus DNA in cholesteatoma may have some role in the development of middle ear cholesteatoma as well as in papilloma" Order ALL the reference details at left...
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/01/2001 - "A study on expression of tumor necrosis factor alpha in middle ear cholesteatoma and its effect on bone destruction]" 03/01/1999 - "Few authors have localized TNF-alpha in aural cholesteatoma" 03/01/1999 - "Aural cholesteatoma: role of tumor necrosis factor-alpha in bone destruction." 02/01/1991 - "Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro." 03/01/1991 - "In this immunoperoxidase study, TNF-alpha was localized in mononuclear cells, macrophages, fibroblasts, osteoblasts, and osteoclasts adjacent to bone resorption areas in both human and experimental middle ear cholesteatomas" Order ALL the reference details at left...
6.	Transforming Growth Factor alpha (TGF-alpha)IBA 01/01/2003 - "OBJECTIVE: To investigate the mode of expression and distribution of transforming growth factor alpha in middle ear cholesteatoma" 03/01/1996 - "TGF-alpha is produced by keratinocytes and has been reported to be overexpressed in several epidermal diseases, including middle ear cholesteatoma" 05/01/1996 - "Expression of transforming growth factor-alpha and epidermal growth factor receptor in middle ear cholesteatoma." 07/01/1993 - "The distribution and expression of TGF alpha and IL-1 alpha were examined in specimens of middle ear cholesteatoma by means of immunohistochemical methods using a monoclonal antibody against TGF alpha and a polyclonal one against IL-1 alpha" 05/01/1996 - "To study the possible autocrine growth stimulation of cholesteatoma epithelium, the expression of transforming growth factor alpha (TGF-alpha) and epidermal growth factor receptor (EGFR) in middle ear cholesteatoma was investigated by immunohistochemical staining techniques" Order ALL the reference details at left...
7.	Epidermal Growth Factor Receptor (EGF Receptor)IBA 10/01/2003 - "Expression of epidermal growth factor receptor in human middle ear cholesteatoma." 03/01/1993 - "Aberrant expression of epidermal growth factor receptor in aural cholesteatoma." 05/01/1996 - "Expression of transforming growth factor-alpha and epidermal growth factor receptor in middle ear cholesteatoma." 03/01/1996 - "Epidermal growth factor receptor (EGF-R) in human middle ear cholesteatoma: an analysis of protein production and gene expression." 07/01/1994 - "The roles of epidermal growth factor (EGF) and epidermal growth factor receptor (EGF-R) in the proliferation and progression of the epithelium of middle ear cholesteatoma were studied" Order ALL the reference details at left...
8.	Epidermal Growth Factor (EGF)IBA 11/01/2004 - "Present data suggests that EGF-treated may induce the occurrence of middle ear cholesteatoma." 01/01/2004 - "Epidermal growth factor expression in middle ear cholesteatoma." 01/01/2004 - "These results show that the distribution of EGF in middle ear cholesteatoma is not deranged and that the progression of cholesteatoma might be induced by the release of factors from the cholesteatoma matrix via autocrine stimulation, or by inflammatory cells of the subepithelial tissue through paracrine stimulation, or in both of these ways." 01/01/2004 - "In middle ear cholesteatoma, EGF was expressed in squamous epithelium in 21 cases (53%), fibroblasts in two cases (5%), and cholesteatoma endothelium in two cases (5%)" 03/01/1996 - "Epidermal growth factor receptor (EGF-R) in human middle ear cholesteatoma: an analysis of protein production and gene expression." Order ALL the reference details at left...
9.	AntigensIBA 07/01/1993 - "Expression of 4F2-activation antigen in middle ear cholesteatoma]" 03/01/1988 - "Human leukocyte antigen-A, -B, -C tissue types in patients with middle ear cholesteatoma." 03/01/1992 - "In the present study we tried to characterize the immunophenotype and the functional state of the cells infiltrating the stroma and the epithelial layer of aural cholesteatoma, using a panel of monoclonal antibodies directed against cell type specific antigens" 05/01/1994 - "Antigen expression of epithelial markers, collagen IV and Ki67 in middle ear cholesteatoma" 09/01/1988 - "Biopsies of middle ear cholesteatomas were examined for Langerhans' cells expressing HLA-DR and anti-Leu 6 antigens by immunohistochemistry using monoclonal antibodies" Order ALL the reference details at left...
10.	Interleukin-1 (Interleukin 1)IBA 02/01/1996 - "Previous studies have demonstrated overexpression of interleukin-1 (IL-1 protein in middle ear cholesteatoma by immunohistochemistry and enzyme-linked immunosorbent assay, suggesting a significant role for IL-1-alpha" 01/01/1996 - "The results point to an over-expression of IL-1 concurrent with a decreased secretion of IL-1-RA in middle ear cholesteatoma" 01/01/1996 - "Interleukin 1 (IL-1) and IL-1-receptor antagonist (IL-1-RA) in middle ear cholesteatoma: an analysis of protein production and biological activity." 09/01/1995 - "Involvement of interleukin-1 in middle ear cholesteatoma." 10/01/1990 - "Interleukin 1 causing bone destruction in middle ear cholesteatoma." Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 06/01/1991 - "Experimental middle ear cholesteatoma originated from free skin graft of the external ear]" 01/01/2001 - "CONCLUSION: If the tympanic and posterior cavities are reasonably safe, middle ear cholesteatoma in adults can be well cured by a one-stage procedure including ossicular chain reconstruction with hydroxylapatite prosthesis covered with cartilage graft who achieved a valuable hearing restoration." Order ALL the reference details at left...
2.	Prostheses and Implants (Prosthesis) 01/01/2001 - "The aim of this retrospective study was to evaluate the long-term hearing results of using costal cartilage prostheses in ossicular chain reconstruction procedures in subjects operated on for a middle ear cholesteatoma with an intact canal wall tympanoplasty" 01/01/2001 - "CONCLUSION: If the tympanic and posterior cavities are reasonably safe, middle ear cholesteatoma in adults can be well cured by a one-stage procedure including ossicular chain reconstruction with hydroxylapatite prosthesis covered with cartilage graft who achieved a valuable hearing restoration." Order ALL the reference details at left...
3.	Solid-State Lasers 03/01/2005 - "Efficacy of the KTP laser in the treatment of middle ear cholesteatoma." Order ALL the reference details at left...
4.	Tympanoplasty 01/01/2008 - "The aim of this study was to present the main principles of tympanoplasty and outcomes of middle ear cholesteatoma surgery through a comparative analysis of the applied tympanoplasty techniques" 04/01/2007 - "The aim of this study was to evaluate the hearing results of ossiculoplasty in canal wall down tympanoplasty in one stage middle-ear cholesteatoma surgery" 03/01/2007 - "METHODS: The study group included 24 ears of 23 patients who underwent staged tympanoplasty for the treatment of middle ear cholesteatoma" 12/01/2001 - "In this study, the effect of aging on hearing results after canal wall reconstruction tympanoplasty was assessed in 236 consecutive ears of 213 patients > 20 years old with middle ear cholesteatoma" 01/01/2008 - "INTRODUCTION: Basic surgical techniques in the treatment of middle ear cholesteatoma include the intact-canal-wall and canal-wall-down tympanoplasty and combined method, i.e" Order ALL the reference details at left...
5.	Middle Ear Ventilation (Tympanostomy) 09/01/1990 - "Of the 30 ears in the study, 20 (66.6%) developed middle ear cholesteatoma--a rate of occurrence comparable to that found in earlier studies in which middle ear ventilation was not provided" Order ALL the reference details at left...

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