|1.||Chromosome Aberrations (Chromosome Abnormalities)
|2.||Visceral Leishmaniasis (Kala Azar)
|5.||Turner Syndrome (Turner's Syndrome)
|1.||Krantz, Ian D: 5 articles (12/2014 - 05/2012)|
|2.||Maserati, Emanuela: 5 articles (09/2010 - 04/2006)|
|3.||Pressato, Barbara: 4 articles (09/2010 - 04/2006)|
|4.||Valli, Roberto: 4 articles (09/2010 - 04/2006)|
|5.||Chen, Chih-Ping: 3 articles (02/2015 - 01/2003)|
|6.||Izumi, Kosuke: 3 articles (12/2014 - 12/2012)|
|7.||Kaur, Maninder: 3 articles (12/2014 - 12/2012)|
|8.||Kotzot, D: 3 articles (01/2011 - 08/2001)|
|9.||Pasquali, Francesco: 3 articles (04/2009 - 04/2006)|
|10.||Kuo, Yu-Ling: 2 articles (02/2015 - 02/2015)|
01/01/2013 - "Cytogenetic analysis showed characteristic karyotype of isochromosome 7. Chronic antigen stimulation due to visceral leishmaniasis may have led to an expansion of gamma delta T cells in our patient, and immunophenotypic analysis of bone marrow aspirate and characteristic karyotype helped to achieve the diagnosis. "
|2.||alemtuzumab (Campath)FDA Link
07/01/1997 - "Laboratory and clinical data suggest great similarity between Sezary cell leukaemia and T prolymphocytic leukaemia (T-PLL), namely coexpression of CD4 and CD8 (3/9 cases), identical chromosomal abnormalities in the three cases studied (isochromosome 8q plus inversion 14 or t(X;14)(q28;q11)) and a remarkable sensitivity to CAMPATH-1H (complete remission of 21 months' duration in one patient), suggesting that this entity could be considered a variant form of T-PLL. "
|3.||Genetic Markers (Genetic Marker)IBA
01/01/1987 - "Immunoglobulin gene rearrangement studies and the presence of a chromosome marker (isochromosome 17q) provided the formal proof that the line has originated from the neoplastic B cells. "
05/01/1975 - "In a patient with eosinophilic leukaemia, serial chromosome studies using the Giemsa banding technique revealed a similar marker chromosome, identified as an isochromosome 17, in all bone marrow metaphases analysed. "
02/01/2015 - "Unusual isochromosome 5p marker chromosome."
05/01/2011 - "Karyotype analysis on amniotic fluid cell cultures revealed a de novo homogenous chromosome marker that we interpreted as an isochromosome Yp. "
01/01/2009 - "A neocentric isochromosome Yp present as additional small supernumerary marker chromosome--evidence against U-type exchange mechanism?"
|4.||trisomy Chromosome 8IBA
01/01/2013 - "In all published cases, the isochromosome 5p was present in single copy and accompanied by one or more additional anomalies, mostly trisomy 8. Here we report a case of refractory cytopenia with multilineage dysplasia with two copies of isochromosome 5p, a single normal chromosome 5and an apparently balanced translocation between long arms of chromosome 7and 10. "
11/01/2004 - "Most frequent alterations included trisomy 8 and 19, extra Ph chromosome, and isochromosome of the 17. "
07/01/2003 - "These include most frequently an extra copy of the Ph chromosome, trisomy 8, and isochromosome 17q. "
02/01/2002 - "Cytogenetically, an isochromosome 7q, trisomy 8, Y-loss, and a translocation t(1;4) was detectable. "
07/01/1997 - "Isochromosome 7q and trisomy 8 were observed. "
|5.||Mosaic variegated aneuploidy syndromeIBA
03/01/1998 - "In a recent study Bugge et al and Kotzot et al reported that isochromosomes 18p originate mainly from maternal meiosis II nondisjunction, followed by misdivision. "
06/15/2004 - "Another monocentric case had 47 chromosomes with isochromosomes i(18p) and i(18q) formed by maternal postzygotic centromeric misdivision and segregation of both isochromosomes, or by meiosis II centromeric misdivision and nondisjunction (without recombination in meiosis I). "
07/22/2001 - "We speculated that the extra chromosome may have resulted from either nondisjunction of chromosome 9 followed by a U-type exchange and a crossing-over between different sister chromatids during maternal meiosis I and subsequent breakage and malsegregation during meiosis II, or nondisjunction during meiosis II followed by isochromosome formation in one of the two maternal chromosomes 9 and subsequent breakage."
07/01/2000 - "On the basis of C-banding pattern, it was hypothesized that these B chromosomes are isochromosomes that have arisen by means of centromere misdivision and chromatid nondisjunction. "
01/01/1999 - "Thus, independently of the chromosomal origin, in the majority of cases with additional euchromatic isochromosomes maternal meiosis nondisjunction is the initial step followed by centromeric misdivision. "
|6.||DNA (Deoxyribonucleic Acid)IBA
06/15/2004 - "DNA studies of mono- and pseudodicentric isochromosomes 18q."
01/01/2007 - "The disomic addition lines 2H, 3H, and 4H and the 1HS isochromosome were identified on the basis of a 2-colour FISH with the DNA probe pairs GAA-pAs1, GAA-HvT01, and pTa71-HvT01. "
06/01/2006 - "Translocations or isochromosome formations at sites of low-copy DNA repeats in 17p10 to 17p12 appear to be the mechanism for the loss of TP53 in B-CLL."
12/15/2004 - "DNA analysis revealed the isochromosome to be paternal in origin, whilst the other two foetal chromosomes 12 were maternal, part iso- and part heterodisomy. "
06/15/2004 - "We have used 23 PCR-based DNA polymorphisms to determine the parental origin and mechanisms of formation in four patients with isochromosomes 18q and to demonstrate that they were consistent with true isochromosomes. "
01/01/1984 - "High resolution chromosome analysis and bromodeoxyuridine (BrdUrd) incorporation have been applied to study patterns of chromosomal replication (inactivation) in two cases of unbalanced X-autosome translocations, seven cases of X and Y chromosome rings or fragments, and five cases of dicentric isochromosomes (Xq). "
11/01/2008 - "Preferential inactivation of Xq isochromosome was demonstrated by bromodeoxyuridine replication analysis and transcriptional silencing by DNA methylation at the HUMARA locus. "
07/12/1978 - "BUdR incorporation revealed the isochromosome X to be late replicating."
08/01/2001 - "However, 83% of women with an X-isochromosome had positive thyroid autoantibodies compared with 33% of women with other karyotypes (P < 0.0001). "
01/01/1995 - "Simultaneous presence of both autoantibodies was significantly more frequent in group 1 (45, X) and group 4 (isochromosome X of the long arm) than in group 3 (mosaicism) (p = 0.04 and p < 0.002, respectively) and significantly more frequent in group 4 than in group 1 (p < 0.05). "
01/01/2011 - "Clinical studies suggest that the thyroid autoantibodies and/or hypothyroidism are not present in Turner's syndrome (TS) patients before the age of 8 years and are more frequent in patients with the X isochromosome. "
|10.||Fluorescent Dyes (Fluorescent Probes)IBA
12/01/2002 - "Does isochromosome 7q mandate bone marrow transplant in children with Shwachman-Diamond syndrome?"
12/01/2009 - "We report a unique KSHV(-) EBV(-) post-transplant effusion lymphoma associated with serum paraproteins, occurring in an HIV(-) individual, which had cytologic features and phenotype similar to PEL, and displayed a complex karyotype including isochromosome 12p and translocation t(8;22), resulting in rearrangement of c-MYC."
10/01/2015 - "CML = Chronic Myeloid Leukemia, BCR-ABL1 = Break Cluster Region - Abelson gene, TKI = tyrosine kinase inhibitor treatment, ACAs = additional cytogenetic abnormalities, CCyR = complete cytogenetic response, PCyR = partial cytogenetic response, mCyR = minor cytogenetic response, MMR = major molecular response, HSCT = hematopoietic stem cell transplant, HLA = human leukocyte antigens, CP = chronic phase, AP = accelerated phase, BP = blast phase, OS = overall survival, CBA = chromosome banding analysis, +8 = trisomy 8, i(17q) = isochromosome (17q), +Ph = second Philadelphia chromosome, -7 = monosomy 7, -17 = monosomy 17, +17 = trisomy 17, -21 = monosomy 21, +21 = trisomy 21, -Y = loss of Y chromosome, ELN = European LeukemiaNet, IMA600 = Imatinib 600 mg daily, IMA400 = Imatinib 400 mg daily, NILO600 = Nilotinib 600 mg daily, DASA100 = Dasatinib 100mg daily, DASA140 = Dasatinib 140 mg daily."
01/01/2012 - "Case report of isochromosome 17q in acute myeloid leukemia with myelodysplasia-related changes after treatment with a hypomethylating agent."
06/01/2006 - "Isochromosome 1q in a myelodysplastic syndrome after treatment for acute promyelocytic leukemia."
12/01/2010 - "Myelodysplastic syndrome with isochromosome 5p and trisomy 8 after treatment of a multiple myeloma."
|3.||Crowns (Crown, Dental)
04/01/2012 - "We conclude that the isochromosome group deviates most from other karyotypes and controls, exhibiting the smallest dental crown width, while individuals with 45,X/46,XX mosaicism seemed to have a less affected crown width. "
04/01/2012 - "Turner syndrome isochromosome karyotype correlates with decreased dental crown width."
01/01/2012 - "The isochromosome TS group exhibited the smallest dental crown width for several teeth, while 45,X/46,XX hade the largest dental crown with for some teeth and fewer teeth than both 45,X and isochromosomes that differed from controls. "
|4.||Estrogen Replacement Therapy