CA-19-9 Antigen (CA 19-9 Antigen)

Sialylated Lewis(a) blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.

Also Known As:

CA 19-9 Antigen; CA 19.9 Antigen; NAG-1,3-F-1,4-GN; Neu5Ac-2-3-Gal-1-3-(Fuc-1-4)-GlcNAc; alpha-Neu5Ac-(2-3)-beta-D-Gal-(1-3)-(alpha-L-Fuc-(1-4))-beta-D-GlcNAc; A, Sialyl Lewis; Antigen CA 19 9; Antigen, CA 19-9; Antigen, CA 19.9; Antigen, CA-19-9; CA 19 9 Antigen; CA-19-9, Antigen; Cancer Antigen, Gastrointestinal; Lewis A, Sialyl; 5-Acetylneuraminyl-2-3-Galactosyl-1-3-(Fucopyranosyl-1-4)-N-Acetylglucosamine; Antigen CA-19-9; Gastrointestinal Cancer Antigen; Sialyl Le(a); Sialyl Lewis A; Sialyl Lewis A Antigen; Sialyl Lewis(a) Tetrasaccharide

Networked: 626 relevant articles (10 outcomes, 72 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kannagi, Reiji: 13 articles (10/2020 - 11/2002)
2.	Ayabe, H: 10 articles (05/2002 - 05/2000)
3.	Nakagoe, T: 10 articles (05/2002 - 05/2000)
4.	Nanashima, A: 9 articles (03/2002 - 05/2000)
5.	Sawai, T: 9 articles (03/2002 - 05/2000)
6.	Tsuji, T: 9 articles (03/2002 - 05/2000)
7.	Yamaguchi, H: 9 articles (03/2002 - 05/2000)
8.	Yasutake, T: 9 articles (03/2002 - 05/2000)
9.	Jeschke, Udo: 8 articles (12/2022 - 05/2005)
10.	Miyazaki, Keiko: 7 articles (05/2012 - 05/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2006 - "The aim of the study was to assess the utility of 2 neoplastic markers, cancer antigen (CA) 19-9 and CA 125, in the differential diagnosis of pancreatic tumors. " 07/01/2004 - "Further studies would be necessary to support the addition to this list, of other tests [e.g., cancer antigen (CA) 19-9]. " 11/01/1982 - "The successful use of the IP assay on fixed tissue to demonstrate the specific sites of gastrointestinal cancer antigen localization in human tumors and normal tissues provides an important tool for the study of developing neoplasia." 11/01/2023 - "There were no differences in baseline prognostic factors, including age, sex, tumor size, tumor location, anatomic resectability, or serum cancer antigen (CA) 19-9 (p > 0.05). " 10/06/2023 - "All sialyl-Lewis A/X-/- tumor cells lacked FUT3 and FUT7 expression as opposed to sialyl-Lewis A/X+/+ or -/+ cell lines. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 05/15/2023 - "Measuring CA 19-9 antigen level is critical for early diagnosis of pancreatic cancer, monitoring the treatment process, and predicting disease recurrence. " 07/01/2012 - "The CA 19-9 antigen is currently the best individual marker for the detection of pancreatic cancer. " 08/01/2011 - "CA 19-9 antigen, routinely used in the monitoring of pancreatic cancer, also has been detected in the tissue of approximately 6% of MTCs. " 01/01/2008 - "Gastrointestinal cancer antigen CA19-9 is known as a valuable marker for the management of patients with pancreatic cancer. " 11/01/1994 - "Levels of Ca 19.9 antigen were measured by enzymeimmunoassay during a 3 year period to 72 patients investigated for suspected pancreatic cancer. "
3.	Stomach Neoplasms (Stomach Cancer) 01/01/2015 - "The clinical value of carbohydrate antigen (CA) 19-9 in gastric cancer is controversial. " 04/01/2002 - "Difference in prognostic value between sialyl Lewis(a) and sialyl Lewis(x) antigen levels in the preoperative serum of gastric cancer patients." 12/01/2001 - "Pre-operative serum levels of STN, sialyl Lewis(a)antigen (CA19-9) and carcinoembryonic antigen (CEA) were examined in 180 patients who underwent resection of gastric cancer. " 04/01/1995 - "Immunohistochemical expression of sialyl Tn and sialyl Lewis(a) antigens in stromal tissue correlates with peritoneal dissemination in stage IV human gastric cancer." 01/01/1990 - "Detection of carbohydrate antigen (CA) 19-9 in tissues and sera was performed by an immunoperoxidase assay and by radioimmunoassay of samples from patients with gastric cancer. "
4.	Carcinoma (Carcinomatosis) 02/01/2023 - "During overall survival analysis (OS), significant factors included age, Eastern Cooperative Oncology Group (ECOG) performance status, differentiation grade G3, carcinoma antigen (CA) 19-9 more than 100 kU/L, absolute white blood cell count, CD3 + CD8+, and CD8 + CD57-T lymphocytes. " 10/15/2005 - "The strong correlation between the promoter activity of the FUT III gene and the high expression of sialyl Le(a) observed in different colon carcinoma cell lines seem to confirm the important regulatory role of FUT3 in the synthesis of sialyl Le(a)." 10/01/2000 - "In 13 cases (29.5%), significant sialyl Le(a) expression was detected not only in the intramucosal carcinoma components, but also in the invasive carcinoma components. " 10/01/2000 - "However, expression patterns of sialyl Le(a) have not yet been established in human esophageal carcinomas. " 07/01/2000 - "However, expression patterns of sialyl Le(a) have not yet been established in human gallbladder carcinomas. "
5.	Colonic Neoplasms (Colon Cancer) 10/01/2004 - "In this study, we investigated the expression of sialyl Lewis(a) antigen in 233 colon cancer specimens from patients who were registered in a prospective adjuvant immunochemotherapy clinical trial. " 10/01/2004 - "However, the prognostic value of sialyl Lewis(a) expression in colon cancer is still controversial. " 05/14/1999 - "Expression of beta3GalT1 transcript is high in normal colon mucosa and control neuroectodermal cells, which do not express sialyl-Lewis a antigen, and low in colon adenocarcinoma cells, as assessed by competitive RT-PCR. " 09/01/1997 - "Variant cell lines with high (WiDr-HA) or low (WiDr-LA) levels of cell surface sialyl Lewis(a) antigen (s-Le(a)) were isolated from the heterogeneous WiDr cells (WiDr-P) in order to characterize the biological behavior of colon cancer cells having elevated cell surface contents of s-Le(a). " 09/01/1997 - "The association of sialyl Lewis(a) antigen with the metastatic potential of human colon cancer cells."

Related Drugs and Biologics

1.	Carbohydrates
2.	Carcinoembryonic Antigen
3.	Tumor Biomarkers (Tumor Markers)
4.	Sialyl Lewis X Antigen
5.	Antigens
6.	Polysaccharides (Glycans)
7.	Enzymes
8.	alpha-Fetoproteins (alpha-Fetoprotein)
9.	Gemcitabine
10.	N-acetyltalosaminuronic acid (NAT)

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Drug Therapy (Chemotherapy)
3.	Gastrectomy
4.	Aftercare (After-Treatment)
5.	Renal Dialysis (Hemodialysis)