Hematopoietic Stem Cell Transplantation

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

Also Known As:

Networked: 14554 relevant articles (1209 outcomes, 1114 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Wang, Yu: 190 articles (10/2022 - 02/2005)
2.	Huang, Xiao-Jun: 179 articles (12/2022 - 01/2007)
3.	Xu, Lan-Ping: 152 articles (12/2022 - 01/2007)
4.	Chen, Huan: 145 articles (05/2022 - 02/2004)
5.	Han, Wei: 144 articles (05/2022 - 08/2004)
6.	Liu, Kai-Yan: 130 articles (10/2022 - 01/2007)
7.	Zhang, Xiao-Hui: 124 articles (10/2022 - 02/2008)
8.	Fukuda, Takahiro: 122 articles (10/2022 - 08/2003)
9.	Locatelli, Franco: 115 articles (01/2022 - 05/2002)
10.	Atsuta, Yoshiko: 110 articles (10/2022 - 02/2009)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/14/2022 - "The currently available therapeutic options for patients with TP53-mutated acute myeloid leukemia (AML) are insufficient, as they translate to a median overall of only 6-9 months, and less than 10% of patients undergoing the most aggressive treatments, such as intensive induction therapy and allogeneic hematopoietic stem cell transplantation, will be cured. " 01/01/2021 - "Allogeneic hematopoietic stem cell transplantation (HSCT) remains the most effective postremission therapy conferring the chance of cure for acute myeloid leukemia (AML), including elderly patients. " 12/01/2019 - "Allogeneic hematopoietic stem cell transplantation (HCT) offers the most effective prevention of relapse and has significant overall survival (OS) benefits for patients with acute myeloid leukemia (AML) in first complete remission (CR1). " 10/01/2018 - "Allogeneic hematopoietic stem cell transplantation (HSCT) is the most powerful therapy preventing relapse in patients with adverse cytogenetics acute myeloid leukemia (AML) in first complete remission (CR1). " 01/01/2010 - "Autologous hematopoietic stem cell transplantation for acute myeloid leukemia in first complete remission: a meta-analysis of randomized trials."
2.	Leukemia 10/01/2016 - "Allogeneic hematopoietic stem cell transplantation (HSCT) is the best post-remission therapy for patients with acute leukemia (AL) at high risk of relapse. " 01/01/2016 - "Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective post remission treatment for leukemia, resulting in lower relapse rates than alternative therapies. " 02/01/2010 - "Most children diagnosed with leukemia are cured without hematopoietic stem cell transplantation (HSCT), but for some high-risk subgroups, allogeneic HSCT plays an important role in their therapeutic approach. " 04/01/2009 - "The cure rates for childhood acute leukemia have dramatically improved to approximately 70% overal, with treatments that include intensive cytotoxic chemotherapy and, in some cases, hematopoietic stem cell transplantation. " 01/01/2006 - "Radioimmunotherapy with beta-particle emitters may be most effective for the treatment of bulky disease or as part of a conditioning regimen for hematopoietic stem-cell transplantation, whereas radioimmunotherapy with alpha-particle emitters may be better suited to the treatment of small-volume or minimal residual leukemia. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/22/2023 - "Allogeneic hematopoietic stem cell transplantation (HSCT) is highly effective for treating pediatric high-risk or relapsed acute lymphoblastic leukemia (ALL). " 01/01/2019 - "The remarkable improvement in the prognosis of children with acute lymphoblastic leukemia (ALL) has been mainly achieved through the administration of risk-adapted therapy, including allogeneic hematopoietic stem cell transplantation (HSCT). " 01/01/2017 - "Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL). " 12/15/2011 - "Acute lymphoblastic leukemia (ALL) in second complete remission is one of the most common indications for allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients. " 03/01/2012 - "Outcome of allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission: a single institution study."
4.	Graft vs Host Disease (Graft-Versus-Host Disease) 01/01/2019 - "Background: Although the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) has dramatically improved in the past decade, it is still compromised by transplant-related mortality (TRM), mainly caused by Graft-vs. -Host Disease (GvHD). " 01/01/2020 - "As the use of hematopoietic stem cell transplantation (HSCT) has become a more widespread and effective treatment for hematological malignant and non-malignant conditions, the need to minimize the harmful effects of graft- vs.-host disease (GvHD) has become more important in achieving good outcomes. " 12/01/2019 - "Extracorporeal photopheresis (ECP) therapy has proved to be an effective and safe treatment for graft-versus-host-disease (GvHD), an important complication after hematopoietic stem cell transplantation. " 12/13/2019 - "Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to graft versus host disease (GvHD). " 01/01/2017 - "Despite the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), the procedure is still associated with high toxicity in patients with refractory graft-versus-host disease (GvHD). "
5.	Neoplasms (Cancer) 11/01/2014 - "Patients with advanced malignancies in non-complete remission (CR) have a dismal prognosis after HLA-matched hematopoietic stem cell transplantation (HSCT). " 11/01/2013 - "Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature." 10/01/2012 - "Hematopoietic stem cell transplantation is the only proven cure for the hematopoietic manifestations of FA and aggressive lifelong surveillance for solid tumors is essential." 05/01/2012 - "Limited curative treatment options exist for patients with advanced B-lymphoid malignancies, and new therapeutic approaches are needed to augment the efficacy of hematopoietic stem-cell transplantation (HSCT). " 01/01/2012 - "In the past 3 decades, the number of immunocompromised children has increased steadily because of dramatic improvement in survival rates in certain malignancies as a result of intensive curative treatment regimens and an increase in the number of children undergoing life-saving hematopoietic stem cell transplantation (HSCT). "

Related Drugs and Biologics

1.	Busulfan (Busulfex)
2.	Cyclophosphamide (Cytoxan)
3.	fludarabine
4.	Melphalan (Alkeran)
5.	HLA Antigens (Human Leukocyte Antigens)
6.	Steroids
7.	Cyclosporine (Ciclosporin)
8.	Imatinib Mesylate (Gleevec)
9.	Tyrosine Kinase Inhibitors
10.	Decitabine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Transplantation
4.	Immunotherapy
5.	Consolidation Chemotherapy