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Leukocyte-Adhesion Deficiency Syndrome

Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection.
Also Known As:
Deficiency Syndrome, Leukocyte-Adhesion; Deficiency Syndrome, Leukocyte Adhesion; Leukocyte Adhesion Deficiency Syndrome; Leukocyte-Adhesion Deficiency Syndromes
Networked: 20 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1. Reinfection
2. Wiskott-Aldrich Syndrome
3. Suppuration
4. Hemorrhage
5. Chronic Granulomatous Disease

Experts

1. Jiang, Dongsheng: 1 article (01/2020)
2. Makrantonaki, Evgenia: 1 article (01/2020)
3. Muschhammer, Jana: 1 article (01/2020)
4. Qi, Yu: 1 article (01/2020)
5. Scharffetter-Kochanek, Karin: 1 article (01/2020)
6. Schatz, Susanne: 1 article (01/2020)
7. Sindrilaru, Anca: 1 article (01/2020)
8. Singh, Karmveer: 1 article (01/2020)
9. Wlaschek, Meinhard: 1 article (01/2020)
10. Badolato, Raffaele: 1 article (06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Leukocyte-Adhesion Deficiency Syndrome:
1. SelectinsIBA
2. IntegrinsIBA
3. LigandsIBA
4. Sialyl Lewis X AntigenIBA
5. DaptomycinFDA Link
6. CarbohydratesIBA
7. Monoclonal AntibodiesIBA
8. NADPH Oxidases (NAD(P)H oxidase)IBA
9. L-SelectinIBA
10. ChemokinesIBA

Therapies and Procedures

1. Bone Marrow Transplantation (Transplantation, Bone Marrow)
2. Transplantation
3. Ligation