Blue Nevus

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75 relevant articles (1 outcomes, 5 trials/studies) found for this Disease

Description: Usually a benign tumor, that commonly presents as a solitary blue nodule with spindled MELANOCYTES covered by smooth SKIN. Several variants have been identified, one variant being malignant. The blue color is caused by large, densely packed melanocytes deep in the DERMIS of the nevus. In CHILDREN, they usually occur on the BUTTOCKS and LUMBOSACRAL REGION and are referred to as cellular blue nevi. Malignant blue nevi are more commonly found on the SCALP.

Also Known As:

Nevus, Blue; Blue Nevi; Blue Nevus, Cellular; Cellular Blue Nevi; Blue Nevi, Cellular; Nevi, Blue; Nevi, Cellular Blue; Nevus, Cellular Blue; Cellular Blue Nevus

Relationship Network

Disease Context: Research Results

Neoplasms: 387640

Neoplasms by Histologic Type: 1

Nevi and Melanomas: 26

Nevus: 1112

Pigmented Nevus: 365

Blue Nevus: 75

Related Diseases

1.	Seborrheic Keratosis
2.	Fibrosis (Cirrhosis)
3.	Cysts
4.	Telangiectasis (Telangiectasia)
5.	Melanoma (Melanoma, Malignant)

Experts

1.	Gasior-Chrzan, B: 1 article (01/2001)
2.	Minami, H: 1 article (05/2000)
3.	Sakakibara, N: 1 article (05/2000)
4.	Sato, K: 1 article (05/2000)
5.	Tsuji, T: 1 article (05/2000)
6.	Hasegawa, K: 1 article (05/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Blue Nevus:

1.	Melanins (Melanin)IBA 12/01/1997 - "In this study synthetic melanin powder and pigmented dermal tissue obtained from five blue nevus lesions, also classified as dermal melanocytosis, were used as targets to identify the specific effects of these forms of irradiation in vitro" 09/01/1997 - "This study describes 9 cases of hypopigmented blue nevus (HBN), a variant of common blue nevus in which there is minimal identifiable melanin pigment" 06/01/1969 - "Electron microscopic study of melanin-phagocytosis by cutaneous vessels in cellular blue nevus." 11/01/2007 - "Epithelioid blue nevus is characterized by large epithelioid melanocytes with abundant cytoplasm and melanin often concentrated to some degree in the cell membrane" 02/01/2002 - "This variant of blue nevus is composed of melanin laden large polygonal epithelioid melanocytes situated within the dermis" Order ALL the reference details at left...
2.	neodymium pyrocatechin disulfonate (NPD)IBA 03/01/2007 - "Qualitative assessment suggested that melanin appeared darker and blue nevi had more shades of blue on PD compared with NPD images; vessels and red areas were better visualized with PD, suggesting that PD may be helpful in identifying malignancies; milialike cysts and comedolike openings were better visualized with NPD, suggesting that NPD is more helpful for identification of seborrheic keratosis; peppering, lighter colors, and blue-white areas were more evident under NPD, facilitating recognition of regression areas; and shiny-white streaks, possibly representing fibrosis, were seen more clearly under PD" Order ALL the reference details at left...
3.	S100 Proteins (S 100 Protein)IBA 01/01/1985 - "The demonstration of S-100 protein in the blue nevus cells before and after bleaching in the present study, along with the ultrastructural observations, supports combined melanocytic and schwannian differentiation of the blue nevus cell." 01/01/1985 - "Immunocytochemical studies for the localization of S-100 protein in the blue nevus cells were performed" 07/01/1986 - "Three common blue nevi from skin of the trunk and upper extremities, and 5 from oral mucosae were studied using an immunoperoxidase stain for S-100 protein" 07/01/1986 - "S-100 protein content of dermal and oral mucosal blue nevi." 01/01/1986 - "Blue nevus, nevus of Ota and mongolian spot revealed the presence of a small amount of S-100 protein and NSE on the half cases" Order ALL the reference details at left...
4.	ParaffinIBA 03/01/1989 - "The recently described method of staining nucleolar organizer regions (NOR) with colloidal silver nitrate was applied to the paraffin sections of five junctional nevi, 13 compound nevi, seven Spitz nevi, nine cellular blue nevi, 11 dysplastic nevi, seven malignant lentigines, 12 superficial spreading melanomas, and 14 secondary melanomas" 04/01/1996 - "We have investigated immunohistochemically the expression of CD44S and the variant isoforms CD44v3 and CD44v6 in paraffin-embedded tissue from 5 Spitz nevi, 3 compound melanocytic nevi, 2 blue nevi, 6 primary melanomas, 15 cutaneous metastases (three epidermotropic, nine dermal and three ulcerated) and 10 lymph node metastases of melanoma" 08/01/1991 - "Using a silver staining technique, we studied nucleolar organizer regions (AgNOR) in paraffin sections of junctional nevi, compound nevi, intradermal nevi, blue nevi, dysplastic nevi, Spitz nevi, lentigo maligna, malignant melanomas in nevus, superficial spreading melanomas, and nodular melanomas" 04/01/1999 - "Tissue samples of 55 formalin-fixed, paraffin-embedded melanoma (primary n=32, metastatic n=23) and of 27 control cases (junctional dermal, compound, Spitz, Reed, blue nevi, balloon-cell nevus, lentigo maligna) were analyzed by immunohistochemistry with anti-cellular apoptosis susceptibility antibodies" 12/01/1993 - "The proliferative activity of four malignant cellular blue nevi (MCBN) was assessed in routinely fixed, paraffin-embedded material using staining for the argyrophilic nucleolar organizer regions (AgNORs), immunohistochemical staining for proliferating cell nuclear antigen (PCNA [PC10]), and DNA flow cytometry" Order ALL the reference details at left...
5.	tebufenozide (Mimic)IBA 01/01/2002 - "Our findings confirm that CBN is a distinctive variant of blue nevus that may mimic cutaneous melanoma both clinically and dermoscopically." 08/01/2000 - "BACKGROUND AND OBJECTIVES: Blue nevi are benign pigmented dermal lesions that can mimic cutaneous melanoma in appearance" 06/01/2008 - "The histologic features of this benign tumour may mimic those of certain benign (dermatofibroma and desmoplastic cellular blue nevus) or malignant (metastatic carcinoma and malignant melanoma) neoplasms" 01/01/2004 - "Hyalinizing Spitz nevus is a benign lesion whose histologic features may mimic dermatofibroma, desmoplastic cellular blue nevus, metastatic carcinoma, and malignant melanoma" 01/01/2004 - "The histologic features of this benign tumor can mimic those of certain benign (dermatofibroma and desmoplastic cellular blue nevus) and malignant (metastatic carcinoma and malignant melanoma) neoplasms" Order ALL the reference details at left...
6.	9,10-Dimethyl-1,2-benzanthracene (DMBA)IBA 01/01/1991 - "A single application of DMBA as an initiator and subsequent thrice-weekly exposures to either UVB (290-320 nm) or UVA (320-400 nm) or the combined exposures of UVA and UVB resulted in the formation of blue nevus-like lesions" 01/01/1967 - "Production of melanomas from DMBA-induced "blue nevi" in hairless mice with ultraviolet light." 04/01/1980 - "Ultrastructural observations on DMBA-induced dermal hyperpigmentation and blue nevus-like tumors in the Mongolian gerbil." Order ALL the reference details at left...
7.	NAD (NADH)IBA 01/01/1989 - "The characteristic histologic features of DPN also allow its differentiation from spindle cell and epithelioid cell nevi and blue nevi." 01/01/2006 - "BACKGROUND: Deep penetrating nevus (DPN) is a distinct variant of melanocytic nevus and remains a histopathologic challenge to pathologists because of its resemblance to blue nevus, malignant melanoma, pigmented Spitz nevus, and congenital melanocytic nevus" 12/01/2000 - "It shows morphologic overlap with the epithelioid blue nevus described by Carney (ECN-CC), deep penetrating nevus (ECN-DPN), and blue nevus with intradermal Spitz's (desmoplastic) nevus (ECN-BLITZ)" Order ALL the reference details at left...
8.	CollagenIBA 02/01/2003 - "In other areas, pigmented spindled and dendritic cells infiltrated thickened collagen bundles in a pattern of a blue nevus" 06/01/2000 - "In 10 of 112 common blue nevi, fascicles of pigmented dendritic melanocytes or less pigmented spindle-shaped melanocytes with S-shaped nuclei were associated with wavy delicate collagen bundles" 11/01/1983 - "This correlated histologically with a peripheral alteration of dermal collagen accompanied by a focal regression or differentiation of blue nevus cells" Order ALL the reference details at left...
9.	styrene-methylmethacrylate copolymerIBA 08/01/1997 - "Histologically, 21 cases were pigmented nuvus on the oral mucosa (18 cases with nevocellular nevus and 3 cases with the common blue nevus), 2 cases were junctional change, 5 cases were the lentigo simplex, and 13 cases were oral melanotic macule" 02/01/2004 - "The blue nevus is a rare lesion on genital mucosa and may cause confusion in differential diagnosis with other pigmented lesions such as genital melanocytic macules, lentigo simplex, and malignant melanoma" 11/01/1993 - "Lesions were classified as lentigo simplex, congenital nevus, "common" nevus, dysplastic nevus, blue nevus, Spitz's nevus or malignant melanoma" Order ALL the reference details at left...
10.	Proliferating Cell Nuclear Antigen (PCNA)IBA 09/01/2008 - "In cellular blue nevi or lesions with similar histopathological features, it may be appropriate to consider the predominant involvement of the capsule as well as the benign cytological features and the immunohistochemical profiles (Ki-67-, PCNA-, and c-kit+) of the nodal cells to be a benign sign." 12/01/1993 - "The proliferative activity of four malignant cellular blue nevi (MCBN) was assessed in routinely fixed, paraffin-embedded material using staining for the argyrophilic nucleolar organizer regions (AgNORs), immunohistochemical staining for proliferating cell nuclear antigen (PCNA [PC10]), and DNA flow cytometry" Order ALL the reference details at left...

Therapies and Procedures

1.	Semiconductor Lasers 12/01/2004 - "OBJECTIVE: The purpose of this study was to compile treatment data and to examine the effectiveness of a longer pulse duration diode laser in the treatment of vascular pathologies such as facial telangiectasia, venous lakes, spider nevi, blue telangiectasia, leg veins and dermatological treatments" Order ALL the reference details at left...
2.	Hysterectomy 11/01/1995 - "The endocervical blue nevus is a rare lesion which can be incidentally found in surgical pieces after hysterectomy in middle-aged women" 01/01/1985 - "Blue nevi of the endocervix appear to be rare incidental lesions; they are often found in hysterectomy specimens from middle-aged women" 10/01/2007 - "The endocervical blue nevi were incidental findings in hysterectomies performed for leiomyomata and endometrial serous carcinoma in women aged 44 and 57 years, respectively" Order ALL the reference details at left...
3.	Solid-State Lasers 02/01/1995 - "Treatment of blue nevi with the Q-switched ruby laser." 02/01/1995 - "We report the successful long-term elimination of common blue nevi on the nasal skin of two patients whose lesions were treated with the laser emission of 694 nm energy from the Q-switched ruby laser." Order ALL the reference details at left...
4.	Laser Therapy (Surgery, Laser) 05/01/2000 - "We investigated as a pilot study whether dermal injection of riboflavin and exposure to near-ultraviolet/visible radiation (ribophototherapy) decreases the dermal pigment of blue nevi which are recalcitrant to laser therapy" Order ALL the reference details at left...
5.	Tissue Expansion Devices (Tissue Expander) 09/01/1995 - "Excision of this unusual plaque-type blue nevus with reconstruction using tissue expander was performed successfully" Order ALL the reference details at left...

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