Amelanotic Melanoma (Amelanotic Melanomas)

Subscribe to Selected New Research on Amelanotic Melanoma

272 relevant articles (5 outcomes, 14 trials/studies) found for this Disease

Description: An unpigmented malignant melanoma. It is an anaplastic melanoma consisting of cells derived from melanoblasts but not forming melanin. (Dorland, 27th ed; Stedman, 25th ed)

Also Known As:

Amelanotic Melanomas; Melanoma, Amelanotic; Melanomas, Amelanotic

Relationship Network

Disease Context: Research Results

Neoplasms: 387349

Neoplasms by Histologic Type: 1

Germ Cell and Embryonal Neoplasms: 2521

Neuroectodermal Tumors: 160

Neuroendocrine Tumors: 1054

Melanoma: 26076

Amelanotic Melanoma: 272

Nevi and Melanomas: 26

Melanoma: 26076

Amelanotic Melanoma: 272

Nerve Tissue Neoplasms: 1

Neuroectodermal Tumors: 160

Neuroendocrine Tumors: 1054

Melanoma: 26076

Amelanotic Melanoma: 272

Related Diseases

1.	Melanoma (Melanoma, Malignant)
2.	Neoplasms (Cancer)
3.	Experimental Melanoma
4.	Adhesions
5.	Leukemia

Experts

1.	Hiratsuka, Junichi: 2 articles (04/2006 - 02/2002)
2.	Osborne, V: 1 article (03/2008)
3.	Harland, C: 1 article (03/2008)
4.	Chetty, N Casie: 1 article (03/2008)
5.	Kozłowska, Krystyna: 1 article (03/2007)
6.	Bryl, Ewa: 1 article (03/2007)
7.	Cichorek, Miroslawa: 1 article (03/2007)
8.	Bryl, E: 1 article (01/2007)
9.	Cichorek, M: 1 article (01/2007)
10.	Kozłowska, K: 1 article (01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amelanotic Melanoma:

1.	Melanins (Melanin)IBA 07/01/2001 - "Fontana-Masson stains and immunohistochemical and ultrastructural studies showed that clinically amelanotic melanoma cells contained melanosomes and rare melanin granules" 09/01/2004 - "Although amelanotic melanoma contains a few melanin granules, it is often difficult to differentiate from non-epithelial malignant tumours" 07/01/2002 - "Histological examination showed features of amelanotic melanoma characterized by absence of melanin pigment." 09/01/2000 - "Pathologic examination of widely resected urethra revealed scattering cells, which included melanin granules in cytoplasm, and then immunohistochemical stains established the diagnosis as amelanotic melanoma" 10/01/1998 - "These findings indicate that the induction of active melanin biosynthesis by melanogenic gene-transfer effectively improves the treatment of amelanotic melanoma by BNCT." Order ALL the reference details at left...
2.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 08/01/1997 - "Unexpectedly, a single treatment of PDT with ALA-induced porphyrin resulted in only one complete remission out of six amelanotic melanomas when the final therapeutic outcome was assessed after 28 days" 02/20/2003 - "Liposomal meso-tetrakis-phenylporphyrin (TPP) was tested for photodynamic therapy (PDT) of human amelanotic melanomas implanted in nude mice" 03/02/1988 - "The results indicate that human xenograft melanotic melanoma, despite the fact that it contains more HpD than does amelanotic melanoma, is far less responsive to PDT" 01/01/1999 - "Dichlorosilicon phthalocyanine (Cl2SiPc) and bis(tri-n-hexylsiloxy) silicon phthalocyanine (HexSiPc) have been evaluated in vitro as potential photosensitizers for photodynamic therapy (PDT) against the human amelanotic melanoma cell line M6" Order ALL the reference details at left...
3.	Fluorouracil (Carac)FDA LinkGeneric 06/01/1988 - "We evaluated the efficacy of intraocular and periocular fluorouracil treatment in an experimental iris tumor of the rabbit (Greene amelanotic melanoma)" 01/01/1997 - "We compared the effects of the radiosensitizers, 5-bromo-2'-deoxyuridine (BUdR) and 5-fluorouracil (5-FU) alone and in combination and cis-diamminedichloroplatinum (cisplatin, DDP) on the growth of B16 amelanotic melanoma (B16a) tumors in mice" Order ALL the reference details at left...
4.	O-(chloroacetylcarbamoyl)fumagillol (TNP 470)IBA 01/01/2002 - "Complete remission of Bomirski Ab amelanotic melanoma in hamsters treated with the angiogenesis inhibitor TNP-470." Order ALL the reference details at left...
5.	4-S-cysteaminylphenolIBA 02/01/1991 - "We have examined the killing effect of 4-S-cysteaminylphenol (4-S-CAP), a newly synthesised melanin precursor, on B16 melanoma cell lines possessing different melanin-producing activities and found it to be particularly effective in heavily melanised melanoma cells, but less so in moderately melanised melanoma cells, and having no effect on amelanotic melanoma cells and nonmelanoma cells" Order ALL the reference details at left...
6.	Monophenol Monooxygenase (Tyrosinase)IBA 01/01/1976 - "Ultrastructural studies of the occurrence of tyrosinase in transplantable amelanotic melanoma in Syrian hamster]" 03/01/2006 - "Remarkably, this heterologous expression system recapitulates the defective processing and mistrafficking of tyrosinase observed in OCA2 albino melanocytes and certain amelanotic melanoma cells" 04/26/2002 - "In tyrosinase-positive amelanotic melanoma cells, inactive tyrosinase accumulates in the endoplasmic reticulum" 12/01/2001 - "However, our results indicate that it can occur directly, as evidenced by the appearance of cutaneous amelanotic melanoma in the tyrosinase-deficient albino mice" 12/01/2001 - "Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase." Order ALL the reference details at left...
7.	Levodopa (L Dopa)FDA LinkGeneric 08/25/1992 - "Rapid, saturable, specific and stereoselective binding of L-dopa to crude membranes and purified nuclei from rodent amelanotic melanoma cells is reported" 07/01/1981 - "Electron microscopy and the L-dopa reaction are emphasized as important adjuncts in the diagnoses of amelanotic melanoma." 07/01/1981 - "A diagnosis of amelanotic melanoma was made by L-dopa reaction and electron microscopy" 12/01/1987 - "Bomirski Ab amelanotic melanoma cells have recently been shown to undergo striking phenotypic changes when precursors of the melanogenic pathway, L-tyrosine and L-dopa, are added to the culture medium" 07/29/1977 - "In a study of the effect of L-dopa, an intermediate in the biosynthesis of the pigment melanin, on the growth of human and murine melanoma cells a highly selective inhibition of growth was observed for pigmented cell lines (S91A and human melanoma) as compared to the nonpigmented control cells (amelanotic melanoma S91B, mouse fibroblast L929, and Chinese hamster ovary)" Order ALL the reference details at left...
8.	Complementary DNA (cDNA)IBA 03/25/1986 - "To know the identity of cDNA, we transfected K1735 amelanotic melanoma and COS-7 cells with the cDNA carried in a simian virus 40 vector (pKCRH2)" 12/01/1993 - "In this study, an expression plasmid for human tyrosinase cDNA was constructed and transfected into a human amelanotic melanoma cell line, G-361" 10/01/2002 - "We have cloned the tryptophan hydroxylase cDNA from hamster pituitary and demonstrated its expression in the skin, melanotic and amelanotic melanomas, spleen, heart, and the eye" 10/01/1998 - "Thus, by using a similarly tyrosinase-lacking mouse amelanotic melanoma cell line, A1059, we constructed TA1059 cells by transfecting human tyrosinase-cDNA into these cells" 12/01/1993 - "Analyses of mixed melanogenesis in tyrosinase cDNA-transfected human amelanotic melanoma cells." Order ALL the reference details at left...
9.	Liposomes (Liposome)IBA 03/15/2004 - "Quantitative fluorescence microscopy of amelanotic melanoma grown in the transparent dorsal skin fold chamber of hamsters demonstrated a favorable drug accumulation in heated tissue after i.v. application of these liposomes (42 degrees C for 1 h)" 02/20/2003 - "Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice." 01/01/1996 - "This study reports that a combination of monoclonal anti-p 120 antibody (MAbp120), liposomes (Lipo), and hyperthermia (HT) resulted in enhanced antitumor effects in cultured human breast adenocarcinoma (MCF-7) and human amelanotic melanoma (LOX) cells" 11/01/1999 - "Incubation of B78H1 amelanotic melanoma cells with a potential photothermal sensitizer, namely, liposome-incorporated Ni(II)-octabutoxy-naphthalocyanine (NiNc), induces an appreciable cellular accumulation of the naphthalocyanine, which is dependent on both the NiNc concentration and the incubation time" 03/01/2005 - "Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation" Order ALL the reference details at left...
10.	CysteinyldopaIBA 01/01/1983 - "Studies on amelanotic melanoma with the fluorescence method (Falck and Hillarp) and biochemical analysis of 5-S-cysteinyldopa in the tissues." 01/01/1983 - "When unpigmented tumors were histopathologically revealed to be malignant, amelanotic melanoma could be definitely diagnosed by the fluorescence method of Falck and Hillarp and the biochemical analysis of 5-S-cysteinyldopa in the tissues." 12/01/1979 - "Detection and quantitation of 5-S-cysteinyldopa in melanotic and amelanotic melanoma in comparison with nonpigment cell tumors and it's urinary excretion." 01/01/1983 - "Results of the determination of 5-S-cysteinyldopa and DOPA in amelanotic melanoma tissues indicated that the specific fluorescence emitted by these cells is primarily due to the presence of 5-S-cysteinyldopa" 02/01/1982 - "Tyrosinase and gamma-glutamyl transpeptidase in 5-s-cysteinyldopa genesis within melanotic and amelanotic melanomas." Order ALL the reference details at left...

Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation) 01/01/2000 - "The parental cell line (A2058) was a human amelanotic melanoma cell line, adaptation of this line to in vivo growth as xenograft the HT168 tumour and its cell line was established" 08/01/2005 - "CLINICAL RELEVANCE: Uveal melanoma research has benefited from xenograft models, but engineered mouse models of spontaneous uveal amelanotic melanoma will undoubtedly further our understanding of the genetic underpinning for this disease." 01/01/2000 - "Tumors of two human amelanotic melanoma xenograft lines (A-07 and R-18) grown intradermally in Balb/c nu/nu mice were used as model system, and muscle tissue was used as control" 01/01/1990 - "Human LOX amelanotic melanoma xenografts in athymic mice were used to explore schedule dependence and activity against natural metastases, and a series of drug-resistant murine leukemias provided an in vivo cross-resistance profile" 01/01/1984 - "Of two human tumor xenografts a malignant amelanotic melanoma responded with slight growth delay, whereas a gastric cancer did not." Order ALL the reference details at left...
2.	Aftercare (After-Treatment) 01/01/1980 - "It has been found that after treatment with trypsin the antgenicity of melanotic melanoma cells increased, while the amelanotic melanoma cells lost their ability to inhibit macrophage migration." 01/01/1977 - "Reported are in vivo trials on Friend virus-leukemia (FVL), on methylcholanthren-induced fibrosarcomas of the mouse, and on amelanotic melanoma No. 3 of the Syrian hamster after treatment with halogenated pyrimidines, 5'-bromodeoxyuridine (BUDR) and 5'-iododeoxyuridine (IUDR) as to provoke genuine oncorna viruses" Order ALL the reference details at left...
3.	Photochemotherapy (Photodynamic Therapy) 03/01/2008 - "Amelanotic melanoma in situ: lack of sustained response to photodynamic therapy." 09/01/2006 - "Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment." 10/01/2005 - "Primary treatment of choroidal amelanotic melanoma with photodynamic therapy." 01/01/1994 - "Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster." 10/01/2005 - "The authors report a case of primary treatment of a small choroidal amelanotic melanoma with photodynamic therapy using verteporfin." Order ALL the reference details at left...
4.	Boron Neutron Capture Therapy 02/01/2002 - "Effect of boron neutron capture therapy for melanotic and amelanotic melanoma transplanted into mouse brain." 04/01/2006 - "Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene." 12/01/1990 - "Experimental boron neutron capture therapy for melanoma: systemic delivery of boron to melanotic and amelanotic melanoma." 10/01/1998 - "Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma." 10/01/1998 - "Specific and powerful cancer killing effect for melanoma by boron neutron capture therapy (BNCT) using DOPA analogue, 10B-p-boronophenylalanine (10B-BPA), has been established, but amelanotic melanoma is insufficiently responsive to 10B-BPA BNCT in comparison with actively melanin-producing melanoma" Order ALL the reference details at left...
5.	Lasers (Laser) 11/01/1995 - "Post-capillary confluent venules (diameter 15-40 microns) of subcutaneous (s.c.) tissue or the amelanotic melanoma A-Mel-3 were observed by intravital microscopy before, 5, 30, 60 and 180 min after laser irradiation and recorded for off-line analysis" 06/01/1999 - "Irradiation of amelanotic melanoma cells with 532 nm high peak power pulsed laser radiation in the presence of the photothermal sensitizer Cu(II)-hematoporphyrin: a new approach to cell photoinactivation." 05/01/2005 - "Irradiation of B78H1 murine amelanotic melanoma cells with 850 nm light emitted from a Ti:sapphire laser, operated in a pulsed mode at high fluence rates and in the presence of Ni(II)-octabutoxy-naphthalocyanine (NiNc), promoted a photothermally sensitised process leading to fast and irreversible cell death" 11/01/1995 - "By cell viability determined with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, the best cell-killing effects were observed after irradiation at 635 nm. Using an amelanotic melanoma (A-Mel-3) grown subcutaneously in Syrian Golden hamsters, we confirmed these results in vivo: tumor growth was markedly delayed in animals treated with 100 mg/kg 5-aminolevulinic acid intravenously and irradiated with coherent light at 635 nm as compared to animals irradiated at 630 nm. This photodynamic effect is probably mediated by large amounts of the photosensitizing porphyrin, protoporphyrin IX, localized in cell membranes as visualized by confocal laser scan microscopy and as determined by high pressure liquid chromatography in vitro" 03/01/2005 - "Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation" Order ALL the reference details at left...

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