Capillary Hemangioma

A dull red, firm, dome-shaped hemangioma, sharply demarcated from surrounding skin, usually located on the head and neck, which grows rapidly and generally undergoes regression and involution without scarring. It is caused by proliferation of immature capillary vessels in active stroma, and is usually present at birth or occurs within the first two or three months of life. (Dorland, 27th ed)

Also Known As:

Networked: 372 relevant articles (27 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Epiretinal Membrane (Epiretinal Membranes)
3.	Hemangioma (Angioma)
4.	Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis)
5.	von Hippel-Lindau Disease (von Hippel Lindau Disease)

Experts

1.	Shields, Carol L: 6 articles (10/2020 - 03/2002)
2.	Shields, Jerry A: 6 articles (10/2020 - 03/2002)
3.	Singh, Arun D: 5 articles (07/2010 - 03/2002)
4.	Hao, Jinsong: 3 articles (01/2016 - 10/2011)
5.	Li, S Kevin: 3 articles (01/2016 - 10/2011)
6.	Liu, Hongzhuo: 3 articles (01/2016 - 10/2011)
7.	Yang, Michael B: 3 articles (01/2016 - 10/2011)
8.	Tian, Y: 2 articles (03/2022 - 09/2008)
9.	Mashayekhi, Arman: 2 articles (10/2020 - 11/2004)
10.	Karimi, Saeed: 2 articles (01/2020 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Capillary Hemangioma:

1.	Retinaldehyde (Retinal)IBA 11/10/2023 - "Multimodal imaging of a macular retinal capillary hemangioma." 01/01/2023 - "Multimodal Imaging and Functional Assessment in a Young Patient Presenting With Concomitant Unilateral Retinal Capillary Hemangioma and Presumed Retinal Pigment Epithelium Dysgenesis." 01/01/2023 - "A hidden isolated retinal capillary hemangioma." 05/01/2022 - "In the eye, retinal capillary hemangioma (RCH) can lead to severe vision loss. " 10/03/2021 - "A retinal capillary hemangioma (RCH) is the earliest manifestation of the VHL disease in most cases.Areas"
2.	Propranolol (Inderal)FDA LinkGeneric 01/01/2018 - "Oral propranolol is highly effective and safe in the treatment of periocular capillary hemangiomas in infants." 05/01/2023 - "Cutaneous capillary hemangioma was an incidental finding in this JS patient and responded favorably to medical treatment with propranolol where a significant reduction in the size of the mass was observed. " 12/01/2012 - "According to previous researches, propranolol seems to be an effective and safe drug to treat capillary hemangioma. " 10/01/2011 - "Oral propranolol has become a promising treatment of capillary hemangiomas (CHs) despite concerns of side effects associated with systemic beta-blockers. " 01/01/2021 - "To evaluate the efficacy of oral propranolol in the treatment of periocular infantile capillary hemangioma (CHI) based on the involvement of embryological facial placodes and their extent of anatomical involvement. "
3.	Timolol (Blocadren)FDA LinkGeneric 11/01/2021 - "Topical timolol maleate 0.5% can be the first-line treatment modality for superficial capillary hemangiomas due to its better safety and efficacy." 03/01/2012 - "Topical timolol maleate gel 0.25% is effective in treatment of nonvision-threatening infantile capillary hemangiomas with a superficial component. " 11/01/2021 - "To observe efficacy of Timolol maleate 0.5% by topical and surface application in infantile superficial capillary hemangioma of eyelid. " 09/01/2018 - "The topical β-antagonist, timolol maleate, has also demonstrated efficacy and safety in treating superficial and some deep capillary hemangiomas. " 03/01/2012 - "To evaluate the efficacy of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas. "
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/10/2021 - "Corticosteroids are the most commonly recommended drugs in capillary hemangioma. " 05/01/2012 - "An anatomically based approach to intralesional corticosteroid injection for eyelid capillary hemangiomas." 01/01/2010 - "Iris depigmentation: an unusual complication of intralesional corticosteroid injection for capillary hemangioma." 03/01/1997 - "Injection of corticosteroids is a well-documented and successful mode of treatment for periorbital capillary hemangiomas. " 03/01/1997 - "Ultrasonographically guided injection of corticosteroids for the treatment of retroseptal capillary hemangiomas in infants."
5.	Fluorescein (Funduscein)FDA LinkGeneric 11/01/1983 - "On the basis of ophthalmoscopy, fluorescein angiography, ultrasonography and other studies, the authors presume that the described lesion is a primary acquired benign vascular tumor, most likely a variant of capillary hemangioma. " 09/01/1996 - "We present five patients who developed luxury perfusion following anterior ischemic optic neuropathy in whom fluorescein angiography was misinterpreted as "capillary hemangioma" or neovascularization of the disc. " 09/01/1984 - "Ophthalmoscopic and fluorescein angiographic findings of capillary hemangiomas of the optic disc are summarized to aid in differentiating them from cavernous and racemose hemangiomas. " 08/01/2018 - "The authors demonstrate the improvement of an untreated retinal capillary hemangioma and resolution of ERM with fundus photography, fluorescein angiography, and spectral domain optical coherence tomography. " 01/01/2013 - "Fluorescein angiography demonstrated leakage from the tumor, and a 4-mm lesion of high density was seen on computed tomography, and we diagnosed it as retinal capillary hemangioma. "
6.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 07/01/2002 - "To evaluate the potential benefit and risks of photodynamic therapy (PDT) in the treatment of papillary capillary hemangioma. " 10/26/2018 - "The present study reported a case of juxtapapillary retinal capillary hemangioma (JRCH) that was successfully treated by two sessions of full-fluence photodynamic treatment (PDT) with good visual outcome. " 01/01/2012 - "To report a case of a large anterior retinal capillary hemangioma (RCH) treated successfully with photodynamic therapy (PDT). " 10/01/2014 - "According to our experience, the PDT with Visudyne appears as promising therapy method of juxtapapillary capillary hemangiomas. " 06/01/2014 - "Photodynamic therapy (PDT) is a common treatment on retinal capillary hemangioma. "
7.	Bevacizumab (Avastin)FDA Link 07/01/2023 - "Outcome of Multiple Retinal Capillary Hemangioma Following Focal Laser and Intravitreal Bevacizumab Injection: A Case Report." 10/01/2016 - "Intravitreal bevacizumab and feeder vessel laser treatment for a posteriorly located retinal capillary hemangioma." 03/01/2010 - "Juxtapapillary capillary hemangioma treated by intravitreal injection of bevacizumab combined with posterior subtenon injection of triamcinolone acetonide." 04/01/2015 - "Massive exudative retinal detachment following photodynamic therapy and intravitreal bevacizumab injection in retinal capillary hemangioma." 01/01/2014 - "Persistent exudative retinal detachment after photodynamic therapy and intravitreal bevacizumab injection for multiple retinal capillary hemangiomas in a patient with von Hippel-Lindau disease."
8.	SolutionsIBA 01/01/2014 - "We report an adult patient with a relatively large orbital capillary hemangioma who was successfully treated with a topical β-blocker solution. " 01/01/2014 - "Topical Treatment for Orbital Capillary Hemangioma in an Adult Using a β-Blocker Solution." 02/01/2010 - "Topical treatment for capillary hemangioma of the eyelid using beta-blocker solution." 01/01/2015 - "Thus, we conclude that long-term use of topical 0.5% timolol maleate solution is safe and effective in treating superficial capillary hemangiomas." 01/01/2015 - "We present a case report of two children having large capillary hemangiomas who responded well to topical treatment by 0.5% timolol maleate solution. "
9.	ArgonIBA 07/01/1989 - "Capillary hemangioma (strawberry mark) of infancy: comparison of argon and Nd:YAG laser treatment." 04/01/1989 - "The relationship of argon laser-induced vascular reactions to eruptive capillary hemangioma is discussed." 04/01/1989 - "[Eruptive capillary hemangioma following argon laser therapy of naevus flammeus]." 05/01/1984 - "Except for infants with complications of capillary hemangiomas of infancy we would not recommend argon laser treatment in children under the age of 12." 11/01/1983 - "Argon laser treatment of an eyelid margin capillary hemangioma."
10.	Verteporfin (Visudyne)FDA Link 03/01/2005 - "Verteporfin and photodynamic therapy were effective in achieving closure of large retinal capillary hemangiomas. " 03/01/2005 - "To investigate the efficacy of verteporfin and photodynamic therapy in the treatment of large retinal capillary hemangiomas. " 04/01/2021 - "Regression of a juxtapapillary retinal capillary hemangioma after verteporfin photodynamic therapy." 10/01/2014 - "According to our experience, the PDT with Visudyne appears as promising therapy method of juxtapapillary capillary hemangiomas. " 12/01/2005 - "Transient closure of a retinal capillary hemangioma with verteporfin photodynamic therapy."

Therapies and Procedures

1.	Lasers (Laser) 01/01/2022 - "Endoscopic Transcanal and Transmastoid Laser-Assisted Resection of Middle Ear Capillary Hemangioma." 11/01/2020 - "Compound capillary hemangioma (n = 1) was treated with laser and systemic beta blockers with satisfactory results. " 01/01/1992 - "[Indications for laser in the treatment of capillary hemangioma]." 11/01/1989 - "Capillary hemangiomas: case study of a novel laser treatment and a review of therapeutic options." 05/01/1989 - "Methodological recommendations for applying three methods fo laser treatment of extensive capillary hemangiomas are suggested. "
2.	Photochemotherapy (Photodynamic Therapy) 07/01/2002 - "Benefits and complications of photodynamic therapy of papillary capillary hemangiomas." 04/01/2004 - "[A case of von Hippel-Lindau disease with papillary capillary hemangioma treated by photodynamic therapy]." 11/01/2002 - "To describe a case of exudative retinal capillary hemangioma treated with photodynamic therapy that resulted in an improvement in clinical appearance and visual acuity. " 01/01/2014 - "In conclusion, photodynamic therapy offers promising anatomical and functional results for juxtapapillary retinal capillary hemangioma, providing visual acuity improvement or even stabilization and restriction of enlargement of the lesion. " 01/01/2014 - "Our purpose is to present a case of juxtapapillary retinal capillary hemangioma treated with photodynamic therapy. "
3.	Radiotherapy 01/01/2023 - "Although radiotherapy is quite effective in the treatment of capillary hemangioma, surgery should be preferred, especially in symptomatic patients. " 03/01/2006 - "Stereotactic fractionated radiotherapy for recurrent capillary hemangioma of the cavernous sinus." 01/01/2005 - "CD/PD ultrasound is helpful in monitoring treatment of selected orbital tumors, enables evaluation of biological evolution of capillary hemangioma and assessment of vascularization degree of tumors treated with chemo- and radiotherapy." 07/01/2012 - "However, because partial removal is associated with a high recurrence rate, capillary hemangiomas that cannot be removed radically should be treated with radiotherapy, which offers the possibility of controlling lesion size and preventing tumor recurrence." 03/01/2006 - "Capillary hemangioma of the cavernous sinus is a rare benign skull base tumor that can successfully be treated with radiotherapy. "
4.	Intralesional Injections 12/01/1992 - "We believe these resulted from the hemodynamic continuity of capillary hemangiomas with the orbital and systemic circulation and that intralesional injections are intravascular. " 09/01/1999 - "Intralesional injection of corticosteroids is an effective treatment for capillary hemangiomas. " 03/01/1997 - "Intralesional injection of corticosteroids to treat retroseptal and retrobulbar capillary hemangiomas was found to be a safe and effective treatment modality in our patients. " 05/01/2001 - "Injection pressures exceeding the systemic arterial pressures routinely occur during intralesional injections of corticosteroids into capillary hemangiomas. " 05/01/2001 - "High injection pressure during intralesional injection of corticosteroids into capillary hemangiomas."
5.	Therapeutics 07/01/2004 - "Capillary hemangiomas of the CNS are benign lesions that can be surgically removed and cured without adjuvant therapy." 05/01/2015 - "Deep and extensive pediatric orbital capillary hemangioma can be surgically excised with the suggested technique, which obviates the need for intralesional or systemic medical therapy, yielding optimal cosmetic and functional outcomes, shortly after surgery. " 01/01/1974 - "[Therapy of capillary hemangiomas]." 02/01/1991 - "Pulsed dye laser therapy should be considered as an option in the treatment of capillary hemangiomas, preferably prior to their full evolution. " 01/01/2013 - "Close monitoring of visual development and prompt institution of amblyopia therapy for children with periocular capillary hemangiomas generally preserve vision. "