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Sertoli-Leydig Cell Tumor

A sex cord-gonadal stromal tumor consists of LEYDIG CELLS; SERTOLI CELLS; and FIBROBLASTS in varying proportions and degree of differentiation. Most such tumors produce ANDROGENS in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS.
Also Known As:
Sertoli-Leydig Cell Tumors; Androblastomas; Arrhenoblastomas; Cell Tumor, Sertoli-Leydig; Cell Tumors, Sertoli-Leydig; Sertoli Leydig Cell Tumor; Sertoli Leydig Cell Tumors; Tumor, Sertoli-Leydig Cell; Tumors, Sertoli-Leydig Cell; Androblastoma; Arrhenoblastoma
Networked: 125 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Sertoli-Leydig Cell Tumor
3. Granulosa Cell Tumor
4. Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor)
5. Sertoli Cell Tumor

Experts

1. Young, Robert H: 4 articles (12/2015 - 04/2007)
2. Hamel, Nancy: 3 articles (04/2014 - 12/2011)
3. Foulkes, William D: 3 articles (04/2014 - 12/2011)
4. Soslow, Robert A: 2 articles (12/2015 - 09/2003)
5. Anglesio, Michael S: 2 articles (08/2015 - 01/2012)
6. Morin, Gregg B: 2 articles (08/2015 - 01/2012)
7. Senz, Janine: 2 articles (08/2015 - 01/2012)
8. Huntsman, David G: 2 articles (08/2015 - 01/2012)
9. Gilks, Blake: 2 articles (08/2015 - 01/2012)
10. Yang, Winnie: 2 articles (08/2015 - 01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sertoli-Leydig Cell Tumor:
1. Vincristine (Oncovin)FDA LinkGeneric
2. MicroRNAs (MicroRNA)IBA
3. Dactinomycin (Ac-De)FDA LinkGeneric
4. Cyclophosphamide (Cytoxan)FDA LinkGeneric
5. Testosterone (Sustanon)FDA Link
6. alpha-Fetoproteins (AFP)IBA
7. Inhibins (Inhibin)IBA
8. Adrenocorticotropic Hormone (ACTH)FDA Link
9. Dexamethasone (Maxidex)FDA LinkGeneric
10. Aromatase (CYP19)IBA

Therapies and Procedures

1. Adjuvant Chemotherapy
2. Ovariectomy (Oophorectomy)
3. Laparotomy
4. Drug Therapy (Chemotherapy)
5. Neoadjuvant Therapy