Inverted Papilloma

A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)

Also Known As:

Networked: 264 relevant articles (6 outcomes, 33 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
2.	Neoplasms (Cancer)
3.	Carcinoma (Carcinomatosis)
4.	Papillomavirus Infections
5.	Papilloma (Papillomatosis)

Experts

1.	Danilewicz, Marian: 8 articles (10/2016 - 01/2010)
2.	Stasikowska-Kanicka, Olga: 7 articles (10/2016 - 01/2010)
3.	Cheng, Liang: 5 articles (07/2016 - 12/2006)
4.	Lopez-Beltran, Antonio: 5 articles (07/2016 - 12/2006)
5.	Montironi, Rodolfo: 5 articles (07/2016 - 12/2006)
6.	Wang, Dehui: 4 articles (04/2020 - 05/2002)
7.	Hu, Li: 3 articles (04/2020 - 08/2014)
8.	Kataki, Agapi: 3 articles (12/2018 - 06/2012)
9.	Nakashima, Torahiko: 3 articles (12/2018 - 01/2002)
10.	Yasumatsu, Ryuji: 3 articles (12/2018 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Inverted Papilloma:

1.	ParaffinIBA 09/01/1998 - "Paraffin-embedded tissues of 42 sinonasal inverted papillomas were subjected to polymerase chain reaction using type-specific primers pairs of HPV 6, 11, 16, 18, and 33. " 12/01/1997 - "Ten cases of inverted papilloma and 20 cases of papillary transitional cell carcinoma of the bladder from Chinese patients in Hong Kong were examined for the presence of HPV type 6, 11, 16, 18, 31, and 33 genomes using the polymerase chain reaction and HPV type specific primer probe combinations on paraffin wax embedded biopsy specimens. " 02/01/2011 - "Formalin-fixed and paraffin-embedded tissues from eight cases of inverted papilloma of the bladder were studied. " 02/01/1996 - "-Formalin fixed, paraffin wax embedded sections from 14 cases of inverted papilloma of the urinary bladder were studied retrospectively. " 02/01/2016 - "The immunohistochemical method was used to examine the immunoexpression of ADAM33 in 39 formalin-fixed, paraffin-embedded tissue specimens of sinonasal inverted papillomas (IP), 44 laryngeal squamous cell carcinomas (GI grade = 11, GII grade = 33) and 14 disease-free tissue specimens as a control. "
2.	Formaldehyde (Formol)FDA Link 12/01/1994 - "In addition, we demonstrated accumulation of formalin-sensitive mast cells at the tumor site of nasal inverted papilloma. " 05/01/1993 - "Serial staining of nasal inverted papilloma showed that the number of mast cells and the percentage of formalin sensitive mast cells within 50 microns of the tumor site and 50 microns above the basement membrane were 16576 +/- 5729/mm3 (90.8%) and 4697 +/- 304/mm3 (76.1%), respectively. " 02/01/2011 - "Formalin-fixed and paraffin-embedded tissues from eight cases of inverted papilloma of the bladder were studied. " 02/01/1996 - "-Formalin fixed, paraffin wax embedded sections from 14 cases of inverted papilloma of the urinary bladder were studied retrospectively. " 02/01/2016 - "The immunohistochemical method was used to examine the immunoexpression of ADAM33 in 39 formalin-fixed, paraffin-embedded tissue specimens of sinonasal inverted papillomas (IP), 44 laryngeal squamous cell carcinomas (GI grade = 11, GII grade = 33) and 14 disease-free tissue specimens as a control. "
3.	anlotinibIBA 01/01/2021 - "A Short-Term Efficacy of Anlotinib in the Treatment of Refractory Nasopharyngeal Inverted Papilloma: A Case Report." 01/01/2021 - "To our knowledge, no studies have reported the use of anlotinib in the treatment of locally cancerous nasopharyngeal inverted papillomas that cannot be operated on or treated with radiotherapy. "
4.	AcidsIBA 06/01/2020 - "Inverted papilloma of the urinary bladder shows fluorescence on photodynamic diagnosis using 5-aminolevulinic acid." 12/01/2013 - "5-Aminolevulinic Acid Photodynamic Therapy appears to be an effective treatment of nasal inverted papilloma. " 12/01/2013 - "Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy in treatment of nasal inverted papilloma." 12/01/2013 - "After treated with 5-Aminolevulinic Acid Photodynamic Therapy, the nasal inverted papillomas were removed. " 12/01/2013 - "Three patients with nasal inverted papilloma were treated with 5-Aminolevulinic Acid Photodynamic Therapy at our department from April to September 2012. "
5.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 12/01/2013 - "Evaluate the efficacy of 5-Aminolevulinic Acid Photodynamic Therapy (PDT) in medical treatment of nasal inverted papilloma (NIP). "
6.	Proteins (Proteins, Gene)FDA Link 07/01/2006 - "Using immunohistochemistry, moderate to high levels of HGF and c-Met protein were localized in epithelial cells in inverted papillomas tested in the present study. " 02/01/1996 - "Aims-To study the possible accumulation of p53 protein in inverted papilloma of the urinary bladder.Methods" 01/01/2021 - "Expression of Sp100 Protein in Human Papillomavirus-Associated Sinonasal Inverted Papilloma." 12/01/2018 - "Patients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. " 05/01/2018 - "The analysis of expression of p16 protein in group of 53 patients treated for sinonasal inverted papilloma."
7.	DNA (Deoxyribonucleic Acid)IBA 01/01/1990 - "[Quantitative studies on nuclear DNA content and morphological features in inverted papillomas of the nasal cavities and paranasal sinuses]." 06/01/2010 - "Canine inverted papillomas associated with DNA of four different papillomaviruses." 11/01/2009 - "HPV DNA was detected in 14/20 patients with inverted papillomas (IPs) (70%). " 08/01/2005 - "Human papillomavirus (HPV) transcripts in malignant inverted papilloma are from integrated HPV DNA." 01/01/1999 - "DNA of papillomavirus origin has been identified in the cells of an inverted papilloma by using techniques of in situ hybridisation."
8.	ErbB Receptors (EGF Receptor)IBA 08/01/2008 - "The present study was undertaken to compare positive rate of immunostaining (PR) and positive intensity of immunostaining (PI) of epidermal growth factor receptor (EGFR) in inverted papilloma (IP), synchronous carcinoma with IP and metachronous carcinoma with IP of the nasal cavity. " 12/01/2019 - "Background: Currently, the expression patterns of epidermal growth factor receptor (EGFR) family genes in sinonasal inverted papilloma (SNIP) and inverted papilloma with squamous cell carcinoma (IPwSCC) are not clear.Objective" 08/01/2008 - "Expression of epidermal growth factor receptor in the inverted papilloma and squamous cell carcinoma of nasal cavity." 04/11/2023 - "This study aimed to clarify the roles of high-risk human papillomavirus (HR-HPV) infection and epidermal growth factor receptor (EGFR) exon 20 mutations in sinonasal inverted papilloma (IP) and sinonasal squamous cell carcinoma (SNSCC). " 11/01/2013 - "Epidermal growth factor receptor, p16, cyclin D1, and p53 staining patterns for inverted papilloma."
9.	Biomarkers (Surrogate Marker)IBA 08/01/2022 - "This study aimed to examine whether serum SCCA levels can be used as clinical markers for monitoring recurrence of sinonasal inverted papilloma (IP) during the follow-up period after surgery. " 09/01/2022 - "FOXP3 and p53 status could be potential biomarker of malignant transformation in sinonasal inverted papilloma." 01/01/2017 - "Moreover, an important issue is still the need for a biomarker indicative of inverted papilloma and its malignant transformation. " 07/01/2010 - "Further research on the aetiology of sinonasal inverted papilloma, and on biological markers for its recurrence and malignant transformation, is required. " 06/01/2008 - "To evaluate selected markers in terms of their possible relation to the development of recurrence in microsurgically resected sinonasal inverted papilloma (SIP) in order to advance understanding of the mechanisms pathogenetically involved, and to identify novel biomarkers for individual risk assessment in SIP. "
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/01/2022 - "The aim of our study is to analyze the staining models for VEGF, p16, and p53, as well as to understand the biology of inverted papilloma caused by smoking. " 12/01/2014 - "To investigate the quantification and significance of Msx2, topoII-α; HPV16 and VEGF in sinonasal inverted papilloma(SNIP), to study the correlation among the four factors,and to discover the relationship between Msx2 and topoII-α in the process of SNIP malignant transfomation. " 10/01/2022 - "Prognostic significance of p16, VEGF, and p53 expression patterns, Krouse stage, and smoking status in sinonasal inverted papillomas." 04/01/2012 - "[Significance and expression of VEGF and its receptor in nasal inverted papillomas and the correlation with malignant phenotype]." 02/01/2000 - "[The significance and expression of vascular endothelial growth factor on nasal inverted papillomas]."

Therapies and Procedures

1.	Operative Surgical Procedures 07/01/2005 - "Surgery is the gold standard in the management of inverted papilloma (IP); however, the approach and extent of the surgical procedure are still controversial. " 08/01/2008 - "[A study of surgical procedures for inverted papilloma in the nasal cavity and paranasal sinuses]." 04/01/2015 - "Endoscopic medial maxillectomy (EMM) has become the surgical procedure of choice for resection of maxillary sinus inverted papillomas (IPs). " 08/01/2008 - "We evaluated surgical procedures for recurrence and sites, with special reference to management of the orbital plate of the ethmoid and lacrimal bones, in 24 patients (32 cases) with inverted papilloma of the nasal cavity and paranasal sinuses undergoing surgical resection from 2000. " 12/01/1981 - "More studies focusing on inverted papilloma have been published in recent years, and the authors of these reports have advocated more aggressive surgical procedures in the management of this tumor. "
2.	Radiofrequency Ablation 04/01/2014 - "It is safe and effective to treat nasal inverted papilloma with plasma radiofrequency ablation at low temperature. " 04/01/2014 - "[Nasal mucosa recovery after endoscopic surgery using the plasma radiofrequency ablation at low temperature for treatment of nasal inverted papilloma]." 01/01/2013 - "[Effect analysis of nasal inverted papilloma in nasal cavity and paranasal sinus by radiofrequency ablation under nasal endoscopy]." 01/01/2022 - "Dynamic Incision under Nasal Endoscope and Low-Temperature Plasma Radiofrequency Ablation for Nasal Inverted Papilloma: An Analysis of Differences in Efficacy and the Destructive Effect on Immune Function." 04/01/2014 - "The clinical data of 104 patients with nasal inverted papilloma underwent endoscopic surgery u sing the plasma radiofrequency ablation at low temperature from July, 2008 to July, 2012 were analyzed,and the recovery of mucosa was observed under nasal endoscope. "
3.	Lasers (Laser) 01/01/2007 - "Laser endoscopic coagulation seems to be an effective treatment for multicentric sinonasal inverted papilloma especially for lesions with a difficult surgical access." 07/01/2018 - "Optical coherence tomography and confocal laser scanning microscopy as non-invasive tools in the diagnosis of sinonasal inverted papilloma: a pilot study." 01/01/2007 - "To describe a new method of treatment of multicentric sinonasal inverted papilloma by laser endoscopic coagulation. "
4.	Photochemotherapy (Photodynamic Therapy) 12/01/2013 - "5-Aminolevulinic Acid Photodynamic Therapy appears to be an effective treatment of nasal inverted papilloma. " 12/01/2013 - "Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy in treatment of nasal inverted papilloma." 12/01/2013 - "After treated with 5-Aminolevulinic Acid Photodynamic Therapy, the nasal inverted papillomas were removed. " 12/01/2013 - "Three patients with nasal inverted papilloma were treated with 5-Aminolevulinic Acid Photodynamic Therapy at our department from April to September 2012. " 12/01/2013 - "Evaluate the efficacy of 5-Aminolevulinic Acid Photodynamic Therapy (PDT) in medical treatment of nasal inverted papilloma (NIP). "
5.	Radiotherapy 01/01/2022 - "Treatment of middle ear inverted papillomas is primarily surgical with adjuvant radiation therapy considered for patients with recurrence or malignant transformation. " 10/01/2016 - "She had a history of resection of inverted papilloma of paranasal sinus followed by radiotherapy for eight years before. " 10/01/2013 - "We retrospectively reviewed long-term outcomes of patients with inverted papilloma (IP) treated with radiation therapy at our institution. " 10/01/2013 - "Radiation therapy for sinonasal inverted papilloma." 03/01/2013 - "Radiotherapy for inverted papilloma: a case report and review of the literature."