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Squamous Cell Neoplasms (Squamous Cell Cancer)

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Neoplasms composed of squamous cells of the epithelium. The concept does not refer to neoplasms located in tissue composed of squamous elements.

Also Known As:

Squamous Cell Cancer; Neoplasms, Squamous Cell; Cancer, Squamous Cell; Cancers, Squamous Cell; Cell Cancer, Squamous; Cell Cancers, Squamous; Cell Neoplasm, Squamous; Cell Neoplasms, Squamous; Neoplasm, Squamous Cell; Squamous Cell Cancers; Squamous Cell Neoplasm

Networked: 816 relevant articles (36 outcomes, 160 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Neoplasms: 421329
- Neoplasms by Histologic Type: 1
  - Glandular and Epithelial Neoplasms: 257
    - Squamous Cell Neoplasms: 816

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Adenocarcinoma
4.	Carcinoma (Carcinomatosis)
5.	Esophageal Neoplasms (Esophageal Cancer)

Experts

1.	Psyrri, Amanda: 6 articles (01/2010 - 02/2005)
2.	Posner, M R: 5 articles (02/2010 - 05/2000)
3.	Weinberger, Paul M: 5 articles (01/2010 - 02/2005)
4.	Forastiere, Arlene A: 5 articles (10/2009 - 10/2002)
5.	Sasaki, Clarence: 5 articles (03/2009 - 02/2005)
6.	Cohen, Roger B: 4 articles (03/2010 - 09/2006)
7.	Posner, Marshall R: 4 articles (12/2009 - 12/2004)
8.	Haddad, Robert I: 4 articles (12/2009 - 12/2004)
9.	Krecicki, Tomasz: 4 articles (05/2009 - 09/2004)
10.	Fraczek, Marcin: 4 articles (05/2009 - 09/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Squamous Cell Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 01/01/1988 - "Simultaneous therapy with high-dose cisplatin and radiation for unresectable squamous cell cancer of the head and neck: a phase I-II study." 07/01/1984 - "Cisplatin plus dichloromethotrexate is an active drug combination in squamous cell cancer of the head and neck, and deserves further evaluation in randomized studies and in an adjuvant setting." 07/01/1984 - "A phase I-II trial of cisplatin and dichloromethotrexate in squamous cell cancer of the head and neck." 07/15/2002 - "Cisplatin has been the most promising single chemotherapeutic agent usedagainst head and neck squamous cell cancer to date. " 03/01/1997 - "Cisplatin is an effective anti-neoplastic agent used in the treatment of squamous cell cancer of the head and neck, but with serious side effects. " Order ALL the reference details at left...
2.	Fluorouracil (Carac)FDA LinkGeneric 11/01/1999 - "An orthotopic model of squamous cell cancer of the head and neck was used in vivo to study the CD/5-FC system both alone and with concurrent radiation due to the radiosensitizing properties that 5-FU generates in situ. " 02/01/1991 - "A phase I study of prolonged infusion 5-fluorouracil and concomitant radiation therapy in patients with squamous cell cancer of the head and neck." 12/01/1992 - "Twenty-two patients with inoperable Stage III and IV squamous cell cancer were treated with CDDP (30 or 35 mg/m2 for 5 days every 4 weeks for three courses) and 5-FU (200 or 300 mg/m2 per day continuous i.v. infusion for 12 weeks) with concomitant conventional radiation therapy. " 01/01/1992 - "Intra-arterial versus intravenous 5-fluorouracil infusion was compared in a naturally occurring, auricular epidermal squamous cell cancer in sheep. " 07/15/2000 - "Squamous cell cancers may be preceded by actinic keratoses-premalignant lesions that are treated with cryotherapy, excision, curettage or topical 5-fluorouracil. " Order ALL the reference details at left...
3.	irinotecan (Camptosar)FDA LinkGeneric 07/01/2003 - "CPT-11 as single-agent therapy is modestly effective against squamous cell cancer of the esophagus." 05/01/2004 - "The expressions of p21 and pRB may be good indicators for the sensitivity of esophageal squamous cell cancers to CPT-11: Cell proliferation activity correlates with the effect of CPT-11." 12/01/2001 - "CPT-11 may provide therapeutic efficacy for esophageal squamous cell cancer and the effects correlate with the level of DNA topoisomerase I protein." 12/01/2001 - "In this study, we aim to evaluate the effects of CPT-11 on esophageal squamous cell cancers (ESCC) and to determine the correlation between the effects and the levels of Topo I expression. " 05/01/2003 - "These findings suggest that the combination chemotherapy with CPT-11 and nedaplatin for squamous cell cancer of uterine cervix is very useful in clinical practice. " Order ALL the reference details at left...
4.	Paclitaxel (Taxol)FDA LinkGeneric 04/01/1999 - "Because of its inherent activity against squamous cell cancer of the head and neck and its radiation-sensitizing properties, paclitaxel may be a valuable agent in the treatment of this patient population. " 08/01/1997 - "An update of a phase II study of paclitaxel in advanced or recurrent squamous cell cancer of the cervix." 04/01/2007 - "Both moderately and poorly differentiated squamous cell cancer cells were more sensitive to taxol, paclitaxel, and CBP than to other drugs with inhibition rates of 52.01%, 49.21%, and 40.02% for the former, and 60.02%, 61.16%, and 48.75% for the latter. " 08/01/1997 - "Thirty-two evaluable patients with squamous cell cancer of the cervix were treated with i.v. paclitaxel 250 mg/m2 over 3 h every 21 days. " 12/01/1997 - "The goal of this National Cancer Institute-sponsored phase I trial is to determine the feasibility, toxicity, and pharmacokinetics of continuous-infusion (24 hr/d, 7 d/wk, 7-week total) intravenous paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) combined with standard curative radiotherapy (RT) for previously untreated, locally advanced head and neck squamous cell cancers. " Order ALL the reference details at left...
5.	Methotrexate (Mexate)FDA LinkGeneric 11/01/1987 - "Three hundred and thirteen patients with squamous cell cancer of the head and neck were entered in a randomised clinical trial to determine whether the addition of methotrexate during the course of irradiation improved the rate of primary control and subsequent survival. " 07/01/1995 - "PURPOSE: To compared the response rates and the toxicity of the new antifolate edatrexate (EDX) with that of methotrexate (MTX) in a randomized trial in patients with metastatic or recurrent squamous cell cancer of the head and neck (SCC) and to compare the durations of response and survival. " 01/01/1981 - "Fifty-eight patients with advanced squamous cell cancer of the head and neck have been randomized on a study comparing three different weekly methotrexate (MTX) dose levels followed at 24 hours by standardized folinic acid rescue. " 02/01/1978 - "Thirteen patients with metastatic squamous cell cancer of the lung were treated, in a nonrandomized study, with an oral high-dose methotrexate and citrovorum factor rescue regimen. " 01/01/1994 - "Between March 1990 and March 1992, 89 patients with recurrent and/or metastatic squamous cell cancer of the head and neck were randomised to receive either intravenous methotrexate (MTX) at a weekly dose of 40 mg/m2 plus lonidamine (LND) given orally at a starting dose of 75 mg three times daily for 3 days and then at a dose of 150 mg three times daily (arm MTX + LND) or methotrexate alone (arm MTX) at the same doses as arm MTX + LND. " Order ALL the reference details at left...
6.	docetaxel (Taxotere)FDA Link 07/15/2006 - "Concurrent weekly docetaxel and concomitant boost radiation therapy in the treatment of locally advanced squamous cell cancer of the head and neck." 04/01/2004 - "Adjusting for patient selection suggests the addition of docetaxel to 5-fluorouracil-cisplatin induction therapy may offer survival benefit in squamous cell cancer of the head and neck." 06/01/2002 - "Preclinical data indicate that docetaxel is a potent radiosensitizer and its initial evaluation with concurrent radiation in patients with locally advanced unresectable squamous cell cancer of the head and neck suggests feasibility. " 06/01/2002 - "The activity of docetaxel (Taxotere) as a single agent (overall response rates, 24%-45%) in the treatment of patients with recurrent squamous cell cancer of the head and neck has resulted in the investigation of docetaxel-based doublet and triplet combinations in both the recurrent and neoadjuvant settings. " 06/01/2002 - "The role of docetaxel in the management of squamous cell cancer of the head and neck." Order ALL the reference details at left...
7.	DNA (Deoxyribonucleic Acid)IBA 11/01/2004 - "OBJECTIVES: While evaluating the validity of using normal human mucosal cells from the upper aerodigestive tract as diploid standards for DNA content studies of squamous cell cancer of head and neck by flow cytometry, pseudoaneuploidy was frequently detected. " 11/01/2000 - "The purpose of the study was to evaluate the frequency of abnormal DNA content in squamous cell cancer (SCC) and analyze its correlation with late survival rates after surgical treatment. " 01/01/2007 - "CONCLUSION: These results demonstrate the selective decrease in the DNA base excision repair pathway in combined reflux and methyl-n-amyl nitrosamine-induced squamous cell cancer of the esophagus." 01/01/2007 - "Selective decrease in the DNA base excision repair pathway in squamous cell cancer of the esophagus." 02/01/2006 - "Constituents of tobacco can cause DNA adduct formation and are implicated in head and neck squamous cell cancer (HNSC) development. " Order ALL the reference details at left...
8.	Bleomycin (Blenoxane)FDA LinkGeneric 01/01/1996 - "In this study, we investigated five recently established head and neck squamous cell cancer lines (UT-SCC-2, UT-SCC-8, UT-SCC-9, UT-SCC-12A, UT-SCC-19A) in terms of response to bleomycin and radiation treatment. " 08/01/2005 - "INTRODUCTION: Labeling of bleomycin with Auger-emitter Indium-111 increases cytotoxicity in squamous cell cancer (SCC) cell lines, as we have reported earlier. " 05/01/1998 - "PURPOSE: To investigate the cytotoxicity of bleomycin (BLM), two Auger-emitting bleomycin complexes (indium-111 ((111)In)-BLMC) and (111)InCl3 in three squamous cell cancer (SCC) cell lines. " 05/01/1998 - "Labelling of bleomycin with Auger-emitter increases cytotoxicity in squamous-cell cancer cell lines." 01/01/1996 - "Cytotoxicity of bleomycin and external radiation in squamous cell cancer cell lines of head and neck." Order ALL the reference details at left...
9.	AntigensIBA 03/01/1992 - "[Immunomorphological studies of the antigen associated with squamous cell cancer of the human cervix uteri]" 03/01/1992 - "The existence of the antigen associated with human cervical squamous cell cancer in normal and pathologically changed cervical epithelium was studied. " 04/01/1990 - "There was a high degree of TA-4 antigen expression in the superficial layers of normal squamous epithelium and in well-differentiated squamous cell cancers (SCC). " 01/01/1990 - "[Immunocytochemical detection of antigen associated with squamous cell cancer of the cervix uteri in women]" 01/01/1991 - "We examined the localization of squamous cell cancer associated antigens (SCCAA) in dysplasia, cancer in situ (CIS) and microinvasive SCC of the uterine cervix, since detection of SCCAA in these subjects is highly effective for early diagnosis. " Order ALL the reference details at left...
10.	Messenger RNA (mRNA)IBA 01/01/2007 - "PURPOSE: To investigate the prevalence of lymph node micrometastasis (LNMM) on the basis of the detection of MUC1 mRNA, and assess the impact of these micrometastases on disease-free interval after resection of pathologic N0 (pN0) esophageal squamous cell cancer (ESCC). " 02/01/2004 - "In this study we demonstrated down-regulation of MAL and BENE mRNA in over two-thirds of primary cervical squamous cell cancers (14 and 15 of 20 cases, for MAL and BENE, respectively) when compared to corresponding non-cancerous uterine squamous cells. " 06/01/2005 - "We demonstrated increased expression of Grb10 mRNA in more than one half of primary cervical squamous cell cancers (12 of 15 cases) when compared to corresponding non-cancerous uterine squamous cell tissues. " 09/01/2003 - "Here we demonstrate increased expression of DVL-1 mRNA in over two thirds of primary cervical squamous cell cancers (11 of 15 cases) when compared to corresponding non-cancerous uterine squamous cell tissues. " 08/01/2004 - "DAPK mRNA was not expressed in all laryngeal squamous cell cancers having hypermethylation of DAPK promoter, whereas it was expressed in normal laryngeal mucosa, laryngeal squamous cell cancers without hypermethylation and tumor adjacent tissues. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/1979 - "Complete remission of a squamous cell cancer of the mandible by chemotherapy. " 12/01/1978 - "Until chemotherapy is proved more effective in the initial management of squamous cell cancer of the mouth and throat, radiation and surgery will remain the principal treatment modalities. " 05/01/2006 - "Because of the low efficacy of the present chemotherapy regimens, one should follow new strategies, comparable to those initiated for squamous cell cancer of other organs." 11/01/1985 - "Recent studies have shown improved efficacy of chemotherapy in patients with advanced squamous-cell cancer of the head and neck. " 12/01/2009 - "INTRODUCTION: Data on influence of radio-chemotherapy (RCT) on tumor-infiltrating lymphocytes (TILs) is scarce and no study addressed this issue in esophageal squamous cell cancer (SCC) so far. " Order ALL the reference details at left...
2.	Radiotherapy 03/01/2009 - "The aim of this study is to investigate their value for predicting clinical outcome after radiotherapy of laryngeal squamous cell cancer (LSCC). " 04/01/2006 - "Impact of nutrition support on treatment outcome in patients with locally advanced head and neck squamous cell cancer treated with definitive radiotherapy: a secondary analysis of RTOG trial 90-03." 01/01/2006 - "BACKGROUND: The aim of this study was to assess blood flow (BF) of microvascular free flaps studied with positron emission tomography (PET) in patients with head and neck squamous cell cancer (HNSCC) undergoing major radical surgery 3-4 weeks after high-dose radiotherapy. " 01/01/2004 - "The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for 77 head-and-neck squamous cell cancer (HNSCC) patients receiving postoperative radiotherapy (RT). " 06/01/1995 - "These studies suggest that p53 protein stabilisation as assessed by immunohistochemistry does not have any major relationship with the biological characteristics and outcome of squamous cell cancer treated by accelerated radiotherapy." Order ALL the reference details at left...
3.	Esophagectomy 11/01/2005 - "Esophagectomy thus has become a safe operation and remains the only therapeutic option offering cure for a substantial proportion of patients with squamous cell cancer of the esophagus." 01/01/2009 - "Factors predictive of prognosis after esophagectomy for squamous cell cancer." 01/01/2008 - "CONCLUSIONS: When performing an esophagectomy for thoracic esophageal squamous-cell cancer in patients who have received preoperative CRT, the weakened tracheobronchial wall can potentially be reinforced using a pedicled latissimus dorsi muscle flap." 09/01/2007 - "METHODOLOGY: We tested 18 patients (2 woman and 16 men, mean age 59.4 years) with esophageal squamous cell cancer before and after esophagectomy and 12 healthy people as a control group. " 06/01/2006 - "Effectiveness of radical en-bloc-esophagectomy compared to transhiatal esophagectomy in squamous cell cancer of the esophagus is influenced by nodal micrometastases." Order ALL the reference details at left...
4.	Combination Drug Therapy (Combination Chemotherapy) 09/01/2007 - "Debulking for stage IIIc ovarian squamous cell cancer was performed and she received adjuvant combination chemotherapy. " 09/15/1983 - "In 16 patients with recurrences of squamous cell cancer of the upper aerodigestive system a combination-chemotherapy was performed in three cycles. " 07/01/1989 - "Prognostic factors for chemotherapy response and survival using combination chemotherapy as initial treatment of advanced head and neck squamous cell cancer." 09/01/1984 - "Correlation between response to cisplatinum-combination chemotherapy and subsequent radiotherapy in previously untreated patients with advanced squamous cell cancers of the head and neck." 02/15/1986 - "The degree of differentiation of previously untreated squamous cell cancers of the head and neck does not conclusively predict tumor response to combination chemotherapy, but may reflect differences in natural history. " Order ALL the reference details at left...
5.	Neck Dissection (Radical Neck Dissection) 01/01/2007 - "Improved knowledge about the metastatic behavior of mucosal squamous cell cancer of the head and neck made it possible to reduce the extension of elective and even therapeutic neck dissections by sparing selected levels, thereby reducing morbidity. " 07/01/2008 - "The study included 81 patients treated by surgery including neck dissection for oral or oropharyngeal squamous cell cancer. " 11/01/1998 - "METHODS: This study is primarily based on an analysis of patients from January 1, 1989, through June 4, 1996 assigned to a protocol evaluating resection of oral cavity squamous cell cancer with margin control using Mohs' histographic technique and/or a group of patients with neck assessment of NO on clinical examination who are undergoing supraomohyoid neck dissections. " 01/01/1992 - "Prospective, randomized, clinical study of squamous cell cancer of the mouth: "Radical neck dissection versus conservative neck dissection"]" 11/01/2009 - "N2 disease in patients with head and neck squamous cell cancer treated with chemoradiotherapy: is there a role for posttreatment neck dissection?" Order ALL the reference details at left...

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