Neurocytoma

A benign brain tumor composed of neural elements which most often arise from the SEPTUM PELLUCIDUM and the walls of the lateral ventricles. Immunohistochemistry and electron microscopy evaluations may reveal expression of neuron specific enolase and synaptophysin and cells containing microtubuli, neurosecretory granules, and presynaptic vesicles. (From Acta Med Port 1994 Feb;7(2):113-9)

Also Known As:

Networked: 179 relevant articles (5 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Intracranial Hemorrhages (Intracranial Hemorrhage)
2.	Spinal Cord Neoplasms (Spinal Cord Tumors)
3.	Oligodendroglioma
4.	Neoplasms (Cancer)
5.	Astrocytoma (Pilocytic Astrocytoma)

Experts

1.	Rades, Dirk: 8 articles (07/2006 - 10/2002)
2.	Kim, Dong Gyu: 6 articles (01/2015 - 02/2003)
3.	Paek, Sun Ha: 6 articles (03/2013 - 02/2003)
4.	Schild, Steven E: 6 articles (07/2006 - 12/2004)
5.	Jung, Hee-Won: 5 articles (03/2013 - 08/2005)
6.	Fehlauer, Fabian: 5 articles (01/2005 - 10/2002)
7.	Kim, Chae-Yong: 4 articles (04/2016 - 02/2003)
8.	Park, Chul-Kee: 4 articles (04/2013 - 11/2007)
9.	Park, Sung-Hye: 4 articles (04/2013 - 08/2005)
10.	Berger, Mitchel S: 3 articles (01/2020 - 12/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurocytoma:

1.	AcidsIBA 04/01/2013 - "We describe two cases involving fluorescence-guided resection of extraventricular neurocytoma using 5-aminolevulinic acid (5-ALA) and evaluate the efficacy of the technique. " 04/01/2013 - "5-aminolevulinic Acid fluorescence discriminates the histological grade of extraventricular neurocytoma."
2.	Proteins (Proteins, Gene)FDA Link 11/01/1998 - "Tissue culture of human neurocytomas induces the expression of glial fibrilary acidic protein." 01/01/2014 - "The purpose of this study was to assess DAPK protein expression and promoter hypermethylation in central neurocytoma and oligodendroglioma. " 11/08/2022 - "Whole exome sequencing in 21 neurocytoma tumor tissues identified somatic mutations in the plant homeodomain finger protein 14 (PHF14) in 3/21 (14%) tumors. " 01/01/2014 - "The results show that DAPK promoter hypermethylation and repressed expression of DAPK protein were more common in central neurocytoma than in oligodendroglioma. " 01/01/2014 - "High levels of DAPK protein expression were generally found in oligodendroglioma (90%), compared with 38.5% in central neurocytoma (P = 0.054; not statistically significant). "
3.	2,6-dinitrotoluene (DNT)IBA 03/01/2004 - "In the group of neuronal and mixed glioneuronal neoplasms are lesions with distinctive morphological features that are still not included in a precise classification, including extraventricular neurocytoma, papillary glioneuronal tumor, rosette-forming glioneuronal of the fourth ventricle, glioneuronal with neuropil-like rosette, and DNT-like tumor of the septum pellucidum. " 10/01/2001 - "Tumor cells with immunoreactive bi- or multi-polar processes were mostly encountered in astroglial neoplasms, whereas the small cell component in neurocytomas and DNT was not labeled. " 12/01/2002 - "Because of their histological similarities, it is occasionally difficult to differentiate neurocytoma and dysembryoplastic neuroepithelial tumor (DNT) from oligodendroglial tumors. " 11/01/2008 - "Furthermore, six histological variants of well-known brain tumours have been added, partially because they show different biological behaviour and/or prognosis: pilomyxoid astrocytoma; atypical choroid plexus papilloma; medulloblastoma with extensive nodularity; anaplastic medulloblastoma; extraventricular neurocytoma; non-specific variant of dysembryoplastic neuroepithelial tumour (DNT). " 01/01/2003 - "PGNT may be regarded as a variant of ganglioglioma or as a complex variant of extraventricular neurocytoma and belongs to a wide group of benign, dysembryoplastic or even hamartomatous neuroepithelial tumors, which may differentiate into both, glial or neuronal direction: pleomorphic astrocytoma may posses neurocytic differentiation, desmoplastic infantile ganglioglioma may be regarded as complex superficial dural astrocytoma and DNT may present gliomatous areas (complex DNT). "
4.	ParaffinIBA 03/01/2006 - "Anti-NeuN immunohistochemistry was performed on paraffin-embedded biopsy specimens of 106 diffuse astrocytomas, 100 pilocytic astrocytomas, 107 ependymomas, 59 1p-aberrant oligodendroglial neoplasms, 115 glioblastomas, 115 medulloblastomas, 14 gangliogliomas/gangliocytomas and 10 central neurocytomas. " 01/01/2003 - "As the diagnostic criteria for central neurocytoma include immunohistochemical and/or ultrastructural evidence for neuronal differentiation, NeuN as a sensitive and specific neuronal marker in formalin-fixed, paraffin-embedded tissues may greatly facilitate the differential diagnosis of central neurocytomas." 10/01/2001 - "In the present study, we systematically analyzed the expression of MAP2 in a series of 237 human neuroepithelial tumors including paraffin-embedded specimens and tumor tissue microarrays from oligodendrogliomas, mixed gliomas, astrocytomas, glioblastomas, ependymomas, as well as dysembryoplastic neuroepithelial tumors (DNT), and central neurocytomas. " 04/01/1991 - "Western blots also revealed expression of the synaptic vesicle protein, synapsin I, neurofilament protein and glial fibrillary acidic protein in several neurocytomas which failed to exhibit immunoreactivity to these marker antigens on paraffin sections. "
5.	Mucin-1 (CA 15-3 Antigen)IBA 01/01/2021 - "This study has assessed the diagnostic ability of oligodendrocyte-2 (Olig2), CD99, and epithelial membrane antigen (EMA) immunohistochemical stains to diagnose oligodendroglial-like neoplasms as central neurocytoma, ependymoma, or oligodendroglioma. " 05/01/2015 - "Postoperative histological examination of the tumor demonstrated that synaptophysin, chromogranin-A and neuron-specific enolase were positive, while luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, adrenocorticotropic hormone, thyroid-stimulating hormone, glial fibrillary acidic protein, S-100, nestin and epithelial membrane antigen were negative, which were the main pathological features of neurocytomas. "
6.	Biomarkers (Surrogate Marker)IBA 01/01/2019 - "Hypothalamic neurocytoma is a tumor that can mimic pituitary neuroendocrine tumors and olfactory neuroblastoma but is distinguished by positivity for neurofilaments, NeuN, and TTF-1 and negative staining for adenohypophysial biomarkers. " 08/01/2005 - "For investigation of histogenesis of central neurocytomas (CNs), subependymoma (SEs), subependymal giant cell astrocytomas (SEGAs), we studied expression of various neuronal and glial biomarkers by immunohistochemical (IHC) study and reverse transcriptase-polymerase chain reaction (RT-PCR). "
7.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 08/01/2005 - "For investigation of histogenesis of central neurocytomas (CNs), subependymoma (SEs), subependymal giant cell astrocytomas (SEGAs), we studied expression of various neuronal and glial biomarkers by immunohistochemical (IHC) study and reverse transcriptase-polymerase chain reaction (RT-PCR). " 08/01/2012 - "We therefore investigated the expression of activated leukocyte adhesion molecule in 9 malignant glial cell lines, 105 normal/reactive human brain specimens, 248 astrocytomas/glioblastomas, 98 ependymomas, 35 oligodendrogliomas, 10 neurocytomas, 10 primitive neuroectodermal tumors (PNET), and 36 medulloblastomas by immunohistochemistry and in selected cases by reverse transcriptase polymerase chain reaction. "
8.	Glucose (Dextrose)FDA LinkGeneric 10/01/1995 - "To estimate proliferating activity of central neurocytoma, we measured kinetic rate constants and glucose metabolic rate (kinetic-rCMRGI) using dynamic positron emission tomography (PET), as well as autoradiographic rCMRG1 (arg-rCMRG1), in patients with histologically verified central neurocytoma. " 10/01/1995 - "[Kinetics of glucose metabolism in central neurocytomas]." 12/01/2004 - "Methionine and glucose metabolism of central neurocytoma: a PET study."
9.	Neurotransmitter Agents (Neurotransmitter)IBA 05/01/2001 - "Although past electron microscopic studies demonstrated synaptic vesicles in the synapse of central neurocytomas, the kinds of neurotransmitters in central neurocytomas have never been identified. " 05/01/2001 - "The biochemical analysis of neurotransmitters in central neurocytomas." 05/01/2001 - "In this study we analyzed neurotransmitters in an attempt to clarify the tumorigenesis of central neurocytomas. "
10.	Methionine (L-Methionine)FDA Link 12/01/2004 - "Methionine and glucose metabolism of central neurocytoma: a PET study."

Therapies and Procedures

1.	Radiotherapy 03/01/2006 - "After ITR of typical neurocytomas, LC is significantly improved by both conventional radiotherapy and SRS. " 12/01/2020 - "This review aim is to determine the place and the modalities of radiotherapy in the management of neurocytomas. " 12/01/2020 - "[Choice optimisation of radiation therapy technique for central neurocytomas from literature data]." 01/01/2020 - "Cerebellar Neurocytoma with Excellent Response to Radiotherapy." 01/01/2020 - "Central Neurocytoma Treatment Modalities: A Systematic Review Assessing the Outcomes of Combined Maximal Safe Resection and Radiotherapy with Gross Total Resection."
2.	Therapeutics 06/01/2001 - "Radiosurgery with the gamma knife unit provides safe and effective adjuvant therapy after surgical resection of central neurocytomas. " 01/01/2021 - "This retrospective study aims to analyze the prognostic factors and the impact of various therapy tools on atypical central neurocytoma. " 03/01/2015 - "Extraventricular neurocytoma treated with 177Lu DOTATATE PRRT induction and maintenance therapies." 06/01/2014 - "External beam therapy improves local control of partially resected and/or atypical central neurocytoma. " 05/01/2014 - "Brainstem location of neurocytomas often precludes gross total removal of the lesion, and in these cases, adjuvant therapies may be helpful. "
3.	Adjuvant Radiotherapy 11/01/2022 - "Comparison of surgery with or without adjuvant radiotherapy in treating central neurocytoma: a single-center retrospective real-world study." 11/01/2022 - "To investigate the efficacy and safety of adjuvant radiotherapy (RT) in patients with central neurocytoma (CN). " 08/26/2021 - "Impact of Adjuvant Radiotherapy in Patients with Central Neurocytoma: A Multicentric International Analysis." 04/01/2016 - "Hypothalamic Extraventricular Neurocytoma (EVN) in a Pediatric Patient: A Case of EVN Treated with Subtotal Removal Followed by Adjuvant Radiotherapy." 01/01/2016 - "For central neurocytomas, MIB-1 labeling index >4% is predictive of poorer outcome and our data suggest that adjuvant radiotherapy after STR may improve PFS. "
4.	Particle Accelerators 02/01/2003 - "This study presents a case of central neurocytoma successfully treated with linear accelerator (LINAC)stereotactic radiosurgery. " 09/01/2003 - "Between October 1996 and December 2001, four patients with central neurocytoma were treated by surgery and subsequently underwent linear accelerator (LINAC) radiosurgery. "
5.	Drug Therapy (Chemotherapy) 11/01/2019 - "The role of chemotherapy in the treatment of central neurocytoma." 05/01/2010 - "Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue." 02/01/2004 - "Chemotherapy may be useful for recurrent central neurocytomas that cannot be resected and have been radiated, although long-term responses have not been reported for chemotherapy. " 12/01/2003 - "The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature." 01/01/2000 - "Three patients with progressive neurocytoma received chemotherapy after their informed consent was obtained. "