Ganglioglioma

Subscribe to Selected New Research on Ganglioglioma

124 relevant articles (1 outcomes, 14 trials/studies) found for this Disease

Description: Rare indolent tumors comprised of neoplastic glial and neuronal cells which occur primarily in children and young adults. Benign lesions tend to be associated with long survival unless the tumor degenerates into a histologically malignant form. They tend to occur in the optic nerve and white matter of the brain and spinal cord.

Also Known As:

Ganglioglioma, Benign; Ganglioglioma, Intracranial; Ganglioglioma, Malignant; Benign Ganglioglioma; Benign Gangliogliomas; Gangliogliomas; Gangliogliomas, Benign; Gangliogliomas, Intracranial; Gangliogliomas, Malignant; Intracranial Ganglioglioma; Intracranial Gangliogliomas; Malignant Ganglioglioma; Malignant Gangliogliomas

Relationship Network

Disease Context: Research Results

Neoplasms: 387640

Neoplasms by Histologic Type: 1

Germ Cell and Embryonal Neoplasms: 2523

Neuroectodermal Tumors: 161

Neuroepithelial Neoplasms: 203

Glioma: 13184

Ganglioglioma: 124

Glandular and Epithelial Neoplasms: 238

Neuroepithelial Neoplasms: 203

Glioma: 13184

Ganglioglioma: 124

Nerve Tissue Neoplasms: 1

Neuroectodermal Tumors: 161

Neuroepithelial Neoplasms: 203

Glioma: 13184

Ganglioglioma: 124

Related Diseases

1.	Pinealoma (Pineoblastoma)
2.	Epilepsy (Aura)
3.	Neoplasms (Cancer)
4.	Neuroepithelial Neoplasms (Gliomatosis Cerebri)
5.	Astrocytoma (Pilocytic Astrocytoma)

Experts

1.	Nasi, M T: 1 article (11/2006)
2.	Frattarelli, M: 1 article (11/2006)
3.	Paioli, G: 1 article (11/2006)
4.	Guiducci, G: 1 article (11/2006)
5.	Cultrera, F: 1 article (11/2006)
6.	Rumbolt, Zoran: 1 article (11/2005)
7.	Maria, Bernard L: 1 article (11/2005)
8.	Knapp, John: 1 article (11/2005)
9.	Tye, Sandra: 1 article (11/2005)
10.	Olson, Lori: 1 article (11/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ganglioglioma:

1.	Biological Tumor Markers (Tumor Markers)IBA 01/01/1998 - "CONCLUSION: The possibility of long term remission obtained by surgery alone and the lack of specificity of clinical and radiological features of ganglioglioma are additional reasons for an aggressive surgical management of pineal tumors when tumor markers and cytopathological examination of the cerebrospinal fluid are not contributive." Order ALL the reference details at left...
2.	2,6-dinitrotoluene (DNT)IBA 04/01/2005 - "The histological diagnosis was ganglioglioma in 11 cases and DNT in four" 06/01/2002 - "Our data also support the hypothesis of a close histogenetic relationship between DNT, ganglioglioma, and PXA, with a putative common origin from pluripotential progenitor CD34 positive cells of the subpial granular layer" 06/01/1998 - "To our knowledge, this is the first detailed histological, immunochemical and ultrastructural report of a mixed DNT and ganglioglioma." 06/01/1998 - "We postulate that the pluripotential progenitor cells residing in the subpial granular layer may have given rise to the cortical DNT and to the leptomeningeal ganglioglioma" 06/01/1998 - "This apparently mixed lesion suggests that a close histogenetic relationship exists between DNT and ganglioglioma" Order ALL the reference details at left...
3.	DNA (Deoxyribonucleic Acid)IBA 09/01/1988 - "This study describes the flow cytometric deoxyribonucleic acid (DNA) analysis of a resected ganglioglioma" 08/01/2002 - "In the present study the clinical data, histology, proliferation rate, DNA ploidy status and the results of TP53 mutation analysis and comparative genomic hybridization (CGH) of three typical cases of desmoplastic infantile astrocytoma and ganglioglioma are presented" 06/01/2004 - "DNA sequence analysis was carried out in gangliogliomas obtained from 29 epilepsy patients vs. peripheral blood DNA from non-affected control individuals (n = 100)" 04/01/2002 - "The only DNA copy number change found in two tumours (both cerebral GCT) was loss of 13q21, while the other nine aberrations were only encountered once each: the granular cells of one cerebral GCT additionally showed +1p32-pter, +9q33-qter, +20q, -4, and -18q, of the glioblastoma +7 and -10, and of the meningioma -1p and -22q, while the pituitary GCT, the ganglioglioma and the neurinoma showed no imbalances" Order ALL the reference details at left...
4.	SynaptophysinIBA 03/01/1999 - "Synaptophysin staining for ganglioglioma." 01/01/1999 - "Thus, a positive reaction of neurons with synaptophysin and NFP seems to be nonpathognomic in the diagnosis of the neoplastic neuron population in gangliogliomas." 01/01/1999 - "A positive synaptophysin reaction was obtained on the surface of neoplastic neurons in gangliogliomas, as well as on the surface of normal neurons in the encephalon, cerebellum and pons" 01/01/1999 - "The significance of immunocytochemical markers, synaptophysin and neurofilaments in diagnosis of ganglioglioma." 05/01/1998 - "Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma." Order ALL the reference details at left...
5.	ParaffinIBA 06/01/1999 - "This study retrospectively evaluates bcl-2 and bcl-x immunostaining in paraffin-embedded materials in gangliogliomas" 10/01/2003 - "The postoperative paraffin section and immunohistochemistry showed ganglioglioma, GFAP(+), CK(-), NF(+)" 03/01/2006 - "METHODS AND RESULTS: Anti-NeuN immunohistochemistry was performed on paraffin-embedded biopsy specimens of 106 diffuse astrocytomas, 100 pilocytic astrocytomas, 107 ependymomas, 59 1p-aberrant oligodendroglial neoplasms, 115 glioblastomas, 115 medulloblastomas, 14 gangliogliomas/gangliocytomas and 10 central neurocytomas" 05/01/1995 - "Formalin-fixed, paraffin-embedded sections from autopsy cases of AD, Down's syndrome with dementia and AD pathology (DS/AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), Lewy body disease (LBD), Parkinson's disease (PD), corticobasal degeneration (CBD), and young and aged normal brains, and from two surgically resected gangliogliomas were immunostained using antibodies to Ki-67 (MIB-1 clone equivalent) and tau (tau)" 11/01/2000 - "A temporal lobe ganglioglioma, surgically removed from an 8-year-old body, and a human brainstem at the level of locus coeruleus (LC) were processed for light microscopy (LM), with formalin fixation and paraffin embedding, and for electron microscopy (EM) with glutaraldehyde fixation, potassium permanganate postfixation, phosphotungstic acid-hematoxylin block-staining, and epoxy resin embedding" Order ALL the reference details at left...
6.	Messenger RNA (mRNA)IBA 05/01/2008 - "LGA mRNA was also relatively high in ganglioglioma which contains a discernable proportion of neuronal cells, and in oligodendroglioma" 11/01/2004 - "We performed single-cell mRNA analysis to study gangliogliomas obtained from patients with pharmacoresistant epilepsy (n = 6), in order to characterize CD34 expressing cells found in these tumors" 02/01/1988 - "The v-myc probe showed a 4- to 12-fold greater hybridization to the mRNA from two glioblastomas and the medulloblastoma (malignant group) than the mRNA from the cystic cerebellar astrocytoma or the ganglioglioma (benign group)" 10/01/2002 - "For gene expression analysis of CDK5 and DCX, a quantitative real time reverse transcription-PCR TaqMan assay was used with mRNA from gangliogliomas ( n=22) and non-lesional central nervous tissue control tissue ( n=7)" Order ALL the reference details at left...
7.	AntigensIBA 03/01/2002 - "Our goal was to characterize the expression of nestin, a neuroepithelial precursor/stem cell antigen, in gangliogliomas along with other pathological and clinical features of this entity" 10/15/1987 - "No S-antigen and opsin-like immunoreaction was found in malignant teratomas and germinomas of the pineal gland, oat cell tumors, astrocytomas, ependymomas, oligodendrogliomas, glioblastomas, gangliogliomas, gangliocytoma, ganglioneuroblastomas, neuroblastomas, and esthesioneuroblastoma." 06/01/2005 - "In the present study, the distribution of cells of the microglia/macrophage lineage was studied by immunocytochemistry for CD68 and human leucocyte antigen (HLA)-DR in a group of glioneuronal tumours, including gangliogliomas (GG, n = 30), and dysembryoplastic neuroepithelial tumours (DNT, n = 17), from patients with chronic intractable epilepsy" Order ALL the reference details at left...
8.	Androgen Receptors (Androgen Receptor)IBA 08/01/1997 - "In the present study, we investigated the clonality of eight gangliogliomas from female patients using both methylation- and transcription-based clonality assays at the androgen receptor locus (HUMARA) on the X chromosome" 04/01/2007 - "By using the human androgen receptor gene (HUMARA) assay, we found the ganglioglioma and the malignant component to be clonal in origin, suggestive of initial transformation of a single neuroglial precursor cell with subsequent malignant progression" Order ALL the reference details at left...
9.	CollagenIBA 01/01/1992 - "Beside these two typical components for ganglioglioma, an abundance of collagen fibrils and numerous blood vessels were encountered" 12/01/1996 - "These findings suggests that collagen IV and laminin and perivascular inflammation are related to the indolent behavior of gangliogliomas." 12/01/1996 - "Significant deposition of collagen IV and laminin was found in 9 gangliogliomas (47%), but in none of the other gliomas" 12/01/1996 - "We also examined whether the presence of collagen IV and laminin correlated with other features often observed in gangliogliomas, including perivascular lymphocytic inflammation, granular bodies, microcalcification, and subarachnoid extension, and whether any of these features were associated with the patient's clinical course" 12/01/1996 - "Our study compared the relative presence and deposition pattern of collagen IV and laminin in 19 gangliogliomas and in 18 gliomas without ganglion cell differentiation (8 low-grade astrocytomas, 7 anaplastic astrocytomas, and 3 anaplastic mixed gliomas)" Order ALL the reference details at left...
10.	N 30IBA 06/01/2004 - "Conventional MR images, relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) measurements were reviewed in 20 patients with pathologically proven grade 1 and 2 gangliogliomas (n = 20) and compared to a group of grade 2 low-grade gliomas (n = 30)" 06/01/2005 - "In the present study, the distribution of cells of the microglia/macrophage lineage was studied by immunocytochemistry for CD68 and human leucocyte antigen (HLA)-DR in a group of glioneuronal tumours, including gangliogliomas (GG, n = 30), and dysembryoplastic neuroepithelial tumours (DNT, n = 17), from patients with chronic intractable epilepsy" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2006 - "Only 3% of gangliogliomas occur in the brain stem, and its management can be challenging because of the difficulty of radical resection and poor response to both radiotherapy and chemotherapy." 02/01/2007 - "However, the posterior temporal lesion was identified as a malignant ganglioglioma/glioblastoma multiforme variant that recurred multiple times requiring several surgeries, radiation and chemotherapy" 12/01/2006 - "The histological diagnosis was ganglioglioma, WHO grade 2. Although both radiotherapy and chemotherapy were performed following the operation, the tumor remained unchanged" 12/01/2003 - "Based on the above findings, irrespective of radiotherapy or chemotherapy, rare recurrence of malignant evolution, especially tumors of high S-phase fraction on flow cytometry, warrants long-term follow-up, even in a well-differentiated ganglioglioma." 12/01/2003 - "This is the first report of a genetic alteration in glioblastoma arising from a well differentiated ganglioglioma prior to radiation or chemotherapy" Order ALL the reference details at left...
2.	Ventriculoperitoneal Shunt 03/01/1999 - "Extracranial metastasis of an intracranial anaplastic ganglioglioma through a ventriculoperitoneal shunt is reported" 03/01/1999 - "Extracranial metastasis of anaplastic ganglioglioma through a ventriculoperitoneal shunt: a case report." 01/01/1989 - "A melanotic ganglioglioma was biopsied in the pineal region of a 12-month-old girl who preoperatively underwent a ventriculo-peritoneal shunt for hydrocephalus and postoperatively received radiotherapy" Order ALL the reference details at left...
3.	Ventriculostomy 11/01/2006 - "We chose a two-stage approach for treating a tectal ganglioglioma in an adult: endoscopic third ventriculostomy followed by surgical excision" 11/01/2006 - "Two-stage treatment of a tectal ganglioglioma: endoscopic third ventriculostomy followed by surgical resection." Order ALL the reference details at left...
4.	Decompression 06/01/1998 - "A 10-year-old girl underwent radical decompression of a right temporal tumour extending to the insular cortex which proved to be a differentiated ganglioglioma" Order ALL the reference details at left...
5.	Craniotomy 11/01/1998 - "Tumor histologies found at craniotomy were craniopharyngioma, ganglioglioma, and 3 low-grade gliomas" Order ALL the reference details at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>