Cervical Intraepithelial Neoplasia

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1333 relevant articles (62 outcomes, 218 trials/studies) found for this Disease

Description: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)

Also Known As:

Cervical Intraepithelial Neoplasia, Grade III; Cervical Intraepithelial Neoplasms; Intraepithelial Neoplasia, Cervical; Cervical Intraepithelial Neoplasm; Intraepithelial Neoplasm, Cervical; Intraepithelial Neoplasms, Cervical; Neoplasm, Cervical Intraepithelial; Neoplasms, Cervical Intraepithelial; Neoplasia, Cervical Intraepithelial

Relationship Network

Disease Context: Research Results

Neoplasms: 415397

Neoplasms by Histologic Type: 1

Glandular and Epithelial Neoplasms: 252

Carcinoma: 92356

Carcinoma in Situ: 1531

Cervical Intraepithelial Neoplasia: 1333

Related Diseases

1.	Infection
2.	Neoplasms (Cancer)
3.	Carcinoma (Carcinomatosis)
4.	Papilloma (Papillomatosis)
5.	Adenocarcinoma

Experts

1.	Syrjänen, K: 7 articles (02/2007 - 05/2000)
2.	Costa, S: 7 articles (02/2007 - 05/2000)
3.	Paba, P: 6 articles (02/2007 - 01/2006)
4.	Giorgi, C: 6 articles (02/2007 - 01/2006)
5.	Bonifacio, D: 6 articles (02/2007 - 01/2006)
6.	Di Bonito, L: 6 articles (02/2007 - 01/2006)
7.	Santini, D: 6 articles (02/2007 - 01/2006)
8.	Branca, M: 6 articles (02/2007 - 01/2006)
9.	Accardi, L: 6 articles (02/2007 - 01/2006)
10.	Benedetto, A: 6 articles (02/2007 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cervical Intraepithelial Neoplasia:

1.	DNA (Deoxyribonucleic Acid)IBA 08/01/2007 - "Improved rate of high-grade cervical intraepithelial neoplasia detection in human papillomavirus DNA hybrid capture testing." 02/01/2001 - "RESULTS: Quantitative measures of total human papillomavirus deoxyribonucleic acid and high-risk human papillomavirus deoxyribonucleic acid were strongly associated with any cervical intraepithelial neoplasia (P = .005) and high-grade cervical intraepithelial neoplasia (P = .0006), but they improved the sensitivity and negative predictive value of baseline screening only slightly when combined with cervical cytologic examination. " 02/01/1998 - "BACKGROUND: The purpose of this study was to determine the efficacy of a repeat Papanicolaou (Pap) smear and the Hybrid Capture tube-based (HCT) HPV DNA test for detecting cervical intraepithelial neoplasia (CIN) grade 2 or 3 in women with recent atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) Pap smear reports. " 09/01/2008 - "Both of these factors complicate the interpretation of type-specific, vaccine-induced protection against cervical intraepithelial neoplasia (CIN) lesions, in which other HPV DNA types are found along with HPV-16 and -18. " 08/01/2008 - "To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. " Order ALL the reference details at left...
2.	VaccinesIBA 01/01/2007 - "The therapeutic vaccines have also a future in women already infected by HPV and might have an efficiency similar to surgery in the treatment of cervical intraepithelial neoplasia." 08/01/2008 - "HPV VLP vaccines are immunogenic, well tolerated and show remarkable efficacy, achieving >98% protection in randomised clinical trials against the obligate precursor lesions cervical intraepithelial neoplasia grade 2/3 (CIN2/3) and adenocarcinoma in situ. " 10/01/2005 - "Recent evidence indicates that prophylactic vaccines are well tolerated, highly immunogenic and effective in preventing persistent HPV infection and cervical intraepithelial neoplasia (CIN). " 10/01/2004 - "Vaccines against HPV also have promise for the future, but a better understanding of the mechanisms underlying spontaneous clearance of both infection and cervical intraepithelial neoplasia (CIN) of different grades is also essential for optimal intervention. " 04/01/2003 - "Vaccines therefore hold much promise, but a better understanding of the mechanisms underlying spontaneous clearance of both infection and cervical intraepithelial neoplasia (CIN) of different grades is also essential for optimal intervention. " Order ALL the reference details at left...
3.	beta Carotene (Betacarotene)FDA Link 06/01/1997 - "Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of CIN. " 10/01/2001 - "A randomized, double blind, Phase III trial using oral beta-carotene supplementation for women with high-grade cervical intraepithelial neoplasia." 08/01/1997 - "Manetta et al., Beta-carotene treatment of cervical intraepithelial neoplasia: a phase II study. " 11/01/1996 - "beta-Carotene treatment of cervical intraepithelial neoplasia: a phase II study." 10/01/2001 - "To evaluate the effect of daily beta-carotene (30 mg) versus placebo over a 2-year period on cervical intraepithelial neoplasia (CIN) 2 and 3 lesions. " Order ALL the reference details at left...
4.	Vitamin A (Retinol)FDA Link 02/01/1984 - "These results suggest that low serum levels of vitamin A may be associated with the development of cervical intraepithelial neoplasia." 02/01/1984 - "An evaluation of women in the group with cervical intraepithelial neoplasia statistically showed lower levels of serum vitamin A (p = 0.1), although, dietary profiles of both groups did not yield a statistically significant difference (p = 0.7). " 02/01/1984 - "Sexually active women with colposcopically directed, biopsy-proved cervical intraepithelial neoplasia were matched with normal control subjects with regard to age, race, and socioeconomic status, in order to determine if dietary and serum vitamin A (retinol) levels can be considered one of the contributing risk factors for the development of this disease process. " 02/01/1984 - "The relationship of dietary and serum vitamin A to the occurrence of cervical intraepithelial neoplasia in sexually active women." 01/01/1986 - "Forty-two patients were entered into a phase I trial to evaluate the vitamin A derivative, trans-retinoic acid, in cervical intraepithelial neoplasia. " Order ALL the reference details at left...
5.	Acetic Acid (Vinegar)FDA LinkGeneric 11/01/2009 - "OBJECTIVE: To evaluate the efficacy of an electrical impedance probe (Epitheliometer) in the diagnosis of high grade cervical intraepithelial neoplasia (CIN) in women referred with cervical smear abnormalities and to assess the effect of acetic acid (AA) and tissue boundaries on the measurements. " 11/01/2009 - "The detection of cervical intraepithelial neoplasia by electrical impedance spectroscopy: the effects of acetic acid and tissue homogeneity." 08/01/2007 - "CASE: A perimenopausal woman was treated with acetic acid for abnormal Pap smear report (cervical intraepithelial neoplasia 1). " 01/01/2006 - "OBJECTIVE: To determine whether the sensitivity of screening tests that miss small cervical intraepithelial neoplasia (CIN) 2 or worse (e.g., acetic acid-aided visual inspection) is inflated when the criterion standard (colposcopic-directed biopsy) misses the same small CIN 2 or worse. " 01/01/2005 - "OBJECTIVE: Evaluation of visual inspection of the cervix with acetic acid (VIA) for screening cervical intraepithelial neoplasia. " Order ALL the reference details at left...
6.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/01/1999 - "33 of 38 (86,8%) patients with superficial cervical intraepithelial neoplasia grades I and II were treated successfully with PDT. " 01/01/2002 - "BACKGROUND AND OBJECTIVES: To determine the safety and efficacy of 5-aminolevulinic acid (ALA) as a topically applied photosensitizer for photodynamic therapy (PDT) of cervical intraepithelial neoplasia (CIN). " 01/01/2005 - "OBJECTIVES: Photodynamic therapy (PDT) is a minimally invasive treatment for cervical intraepithelial neoplasia (CIN). " 03/01/2003 - "Photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (ALA) has been used to treat histologically confirmed cervical intraepithelial neoplasia (CIN-I and -I/II) in a randomised, double-blind, placebo-controlled protocol. " 10/01/2003 - "We assessed the effectiveness of PDT for treating cervical intraepithelial neoplasia (CIN) by cytological and histological examinations and investigated its impact on human papillomavirus (HPV) infection. " Order ALL the reference details at left...
7.	Interferon-alpha (Interferon Alfa)FDA Link 01/01/1994 - "Interferon alpha 2b treatment of cervical intraepithelial neoplasia grade 2: modulation of natural killer cell." 01/01/1985 - "Leukocyte interferon gel (1 X 10(6) units) was applied twice daily by a vaginal applicator to areas of cervical intraepithelial neoplasia (CIN) in 7 patients. " 01/01/1985 - "Intravaginal application of leukocyte interferon gel in the treatment of cervical intraepithelial neoplasia (CIN)." 04/01/1986 - "Twelve patients with cervical intraepithelial neoplasia (CIN) were studied by colposcopy and cervical smears to elucidate the local response to interferon alpha and beta given by perilesional injections and to assess long-term disease remission. " 08/01/1990 - "In this controlled prospective study, 14 patients with cervical intraepithelial neoplasia (CIN) were observed for one month to exclude spontaneous regression, and then seven patients were treated twice-weekly with perilesional injections of alpha-interferon. " Order ALL the reference details at left...
8.	Papillomavirus Vaccines (HPV Vaccines)IBA 10/01/2000 - "cervical intraepithelial neoplasia grade III, CINIII) is important, to avoid early contamination of the target population by opportunistic use of licensed HPV vaccines. " 08/01/2006 - "Two virus-like particle human papillomavirus (HPV) vaccines have been shown to be nearly 100% effective in preventing type-specific persistent HPV infections and associated type-specific high-grade cervical intraepithelial neoplasia (CIN). " 08/01/2009 - "The introduction of HPV vaccines can also prevent other HPV-related sequelae, most importantly cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3), which precede the development of cervical cancer and require clinical follow-up and treatment. " 03/01/2006 - "Multivalent prophylactic human papillomavirus (HPV) vaccines currently in the late stages of clinical testing are safe, immunogenic, and efficacious; and phase 3 tests of a quadrivalent vaccine show that it is 100% effective at preventing HPV types 16 and 18-associated cervical intraepithelial neoplasia grades 2 and 3, adenocarcinoma in situ, and cervical cancer through 2 years of postvaccination follow-up. " 09/01/2007 - "Preliminary results have also been reported on therapeutic vaccines, notably for the treatment of cervical intraepithelial neoplasia grades 2 and 3. SUMMARY: The safety and efficacy of human papillomavirus vaccines in individuals with HIV need to be assessed to prevent cervical cancer in current and future generations. " Order ALL the reference details at left...
9.	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/01/2003 - "Topical trans-retinoic acid treatment produced a statistically significant regression of cervical intraepithelial neoplasia (CIN) 2, but not CIN 3, in trials. " 04/06/1994 - "Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial." 12/01/2004 - "Low-dose topical delivery of all-trans retinoic acid for cervical intraepithelial neoplasia II and III." 12/01/2004 - "OBJECTIVE: The objective of this study was to determine an effective dose for all-trans retinoic acid (atRA) delivered with a cervical cap and sponge for 4 days to women with cervical intraepithelial neoplasia (CIN) II/III.METHODS: Study participants made up of 175 women with biopsy-proven CIN II/III were randomized to four consecutive days of atRA at one of three doses (0.16%, 0.28%, and 0.36%) or placebo. " 11/01/2001 - "PURPOSE: Previous trials of topical trans-retinoic acid treatment of cervical intraepithelial neoplasia (CIN) grades 2 and 3 led to a statistically significant regression of CIN 2, but not CIN 3. We tested N-(4-hydroxyphenyl)retinamide (4-HPR), a promising oral retinoid that has been shown to induce apoptosis through nonretinoic receptor acid-mediated pathways, for its toxicity and efficacy against CIN 2/3. EXPERIMENTAL DESIGN: In a blinded randomized trial, 4-HPR at 200 mg/day for 6 months (with a 3-day/month drug holiday) was compared with placebo in patients with biopsy-proven CIN-2/3 [high-grade squamous intraepithelial lesions (HGSILs)]. " Order ALL the reference details at left...
10.	AntigensIBA 10/01/2005 - "Differences in human leukocyte antigen (HLA) alleles have been reported in cervical intraepithelial neoplasia (CIN) compared with controls in other populations. " 08/01/1985 - "Comparison of prevalence of human papillomavirus antigen in biopsies from women with cervical intraepithelial neoplasia." 01/01/1985 - "the colposcopic pattern, expression of papillomavirus genus specific structural antigens (demonstrated by an indirect immunoperoxidase, IP-PAP technique), as well as the degree of HPV-associated cervical intraepithelial neoplasia (CIN). " 07/01/1983 - "The prevalence of human papillomavirus antigen in patients with cervical intraepithelial neoplasia." 11/01/1999 - "OBJECTIVE: To evaluate, in a preclinical feasibility study, the efficacy of NMP179, a monoclonal antibody recognizing a cervical tumor-associated nuclear matrix antigen, for the early detection of high and low grade cervical intraepithelial neoplasia. " Order ALL the reference details at left...

Therapies and Procedures

1.	Laser Therapy (Surgery, Laser) 02/01/1983 - "We performed a study to determine the efficacy of laser therapy for the three grades of cervical intraepithelial neoplasia. " 01/01/1990 - "The efficacy of laser therapy in the treatment of cervical intraepithelial neoplasia." 02/10/2003 - "METHODS: A randomized trial of three techniques of conization (cold knife, laser, and loop electrosurgical excisional procedure (LEEP)) for cervical intraepithelial neoplasia (CIN) in which 110 patients had been recruited. " 07/01/2000 - "METHODS: The study population included 426 women with histologic diagnosis of cervical intraepithelial neoplasia (CIN) 2-3, of whom 289 (study group) were treated by LEETZ followed by laser vaporization of the crater base and walls and 137 (control group) were treated by LEETZ alone. " 02/01/1995 - "Clinical trials have found loop excision to be faster and easier than laser ablation for treating cervical intraepithelial neoplasia and to have similar complication and success rates. " Order ALL the reference details at left...
2.	Gas Lasers 11/01/2008 - "AIM: To investigate the therapeutic efficacy of cylindrical or cone-shaped excision performed by laser CO2 in the conservative management of persistent-recurrent high-grade cervical intraepithelial neoplasia (HG-CIN) in women of fertile age. " 04/01/1991 - "Thus in our experience, CO2 laser conization is more effective for clinical diagnosis and treating of cervical intraepithelial neoplasia." 11/01/1989 - "Thus, in our experience, CO2 laser conization is more effective for clinical diagnosis and treating of cervical intraepithelial neoplasia." 01/01/1990 - "The efficacy of carbon dioxide laser therapy in the treatment of cervical intraepithelial neoplasia (CIN) was evaluated in 253 patients treated at the University of Kentucky Medical Center from 1984 to 1987. " 01/01/1985 - "By combining a narrow carbon dioxide laser excisional conization with ectocervical vaporization, cervical intraepithelial neoplasia may be eradicated by a virtually bloodless surgical procedure and fertility may be preserved. " Order ALL the reference details at left...
3.	Lasers (Laser) 01/01/1999 - "In its absence laser conization is highly effective in the treatment of cervical intraepithelial neoplasia, and has the advantage of providing a specimen suitable for the necessary histological investigation." 12/01/2002 - "CONCLUSIONS: The conization with dioxide laser is a good therapy for cervical intraepithelial neoplasia, even if expensive; infact poor side-effects are observed as well as a very good reliability." 05/01/1998 - "AIMS: To examine per- and postoperative complication rates and efficacy of laser conization in the treatment of cervical intraepithelial neoplasia (CIN) grade II-III. MATERIAL AND METHODS: Eligible for analyses were all women treated with their first laser conization because of CIN II-III during the time-period January 1, 1983 to December 31, 1992. " 01/01/2007 - "The current study is an exploratory study to identify candidate surface-enhanced laser desorption/ionization (SELDI) time of flight (TOF) mass spectrometry (MS) protein profiles in plasma that may distinguish cervical intraepithelial neoplasia (CIN 3) from CIN 1 among women infected with HR-HPV. " 05/01/2001 - "STUDY DESIGN: This phase I clinical trial involved 18 women with biopsy-proven cervical intraepithelial neoplasia at the Beckman Laser Institute, Irvine, Calif. " Order ALL the reference details at left...
4.	Diathermy 01/01/1999 - "Thirty-four women with varying grades of cervical intraepithelial neoplasia, 25 patients who had been treated successfully with diathermy loop excision, and 56 women who had no evidence of cervical abnormality acted as controls. " 06/01/1983 - "Cervical intraepithelial neoplasia was eradicated in 97.3% of patients by a single diathermy treatment. " 07/01/2004 - "Needle versus loop diathermy excision of the transformation zone for the treatment of cervical intraepithelial neoplasia: a randomised controlled trial." 04/01/2000 - "STUDY DESIGN: This was a prospective study of 58 unselected women with histologically verified cervical intraepithelial neoplasia who underwent conization with the diathermy needle. " 01/01/2004 - "Both groups were compared regarding the final cytological follow-up, the number of diathermy loop excisions, and the detection of cervical intraepithelial neoplasia. " Order ALL the reference details at left...
5.	Condoms (Condom) 10/20/2004 - "Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: a randomized clinical trial." 12/10/2003 - "Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: a randomized clinical trial." 04/25/2005 - "We earlier demonstrated, in a randomised clinical trial, that the regression time of flat penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN) was shorter in men who used condoms compared to those who did not. " 12/10/2003 - "Condom use promotes regression of human papillomavirus-associated penile lesions in male sexual partners of women with cervical intraepithelial neoplasia." 08/01/1990 - "The effect of condom use on cervical intraepithelial neoplasia grade I (CIN I)." Order ALL the reference details at left...

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