Cervical Intraepithelial Neoplasia

A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Also Known As:
Cervical Intraepithelial Neoplasia, Grade III; Cervical Intraepithelial Neoplasms; Intraepithelial Neoplasia, Cervical; Cervical Intraepithelial Neoplasm; Intraepithelial Neoplasm, Cervical; Intraepithelial Neoplasms, Cervical; Neoplasm, Cervical Intraepithelial; Neoplasms, Cervical Intraepithelial; Neoplasia, Cervical Intraepithelial
Networked: 1878 relevant articles (82 outcomes, 337 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Neoplasms (Cancer)
3. Carcinoma (Carcinomatosis)
4. Papilloma (Papillomatosis)
5. Cervical Intraepithelial Neoplasia


1. Schiffman, Mark: 22 articles (11/2015 - 04/2003)
2. Castle, Philip E: 18 articles (07/2015 - 07/2003)
3. Koutsky, Laura A: 14 articles (11/2015 - 10/2002)
4. Meijer, Chris J L M: 13 articles (06/2015 - 11/2002)
5. Sankaranarayanan, Rengaswamy: 13 articles (10/2013 - 01/2007)
6. Yoshikawa, Hiroyuki: 12 articles (01/2016 - 08/2002)
7. Piyathilake, Chandrika J: 12 articles (01/2014 - 12/2004)
8. Arbyn, Marc: 11 articles (12/2014 - 04/2004)
9. Belinson, Jerome L: 11 articles (06/2014 - 08/2004)
10. Syrjänen, Kari: 11 articles (07/2010 - 08/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cervical Intraepithelial Neoplasia:
1. DNA (Deoxyribonucleic Acid)IBA
01/01/2015 - "The introduction of high-risk human papillomavirus DNA (HPV) detection, as a primary screening cotest with cytology among women over age 40 with a poor screening history, significantly improved the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+), being far superior to cytology alone. "
08/01/2007 - "Improved rate of high-grade cervical intraepithelial neoplasia detection in human papillomavirus DNA hybrid capture testing."
02/01/2001 - "Quantitative measures of total human papillomavirus deoxyribonucleic acid and high-risk human papillomavirus deoxyribonucleic acid were strongly associated with any cervical intraepithelial neoplasia (P = .005) and high-grade cervical intraepithelial neoplasia (P = .0006), but they improved the sensitivity and negative predictive value of baseline screening only slightly when combined with cervical cytologic examination. "
02/01/1998 - "The purpose of this study was to determine the efficacy of a repeat Papanicolaou (Pap) smear and the Hybrid Capture tube-based (HCT) HPV DNA test for detecting cervical intraepithelial neoplasia (CIN) grade 2 or 3 in women with recent atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) Pap smear reports. "
09/01/2008 - "Both of these factors complicate the interpretation of type-specific, vaccine-induced protection against cervical intraepithelial neoplasia (CIN) lesions, in which other HPV DNA types are found along with HPV-16 and -18. "
2. VaccinesIBA
3. Acetic Acid (Vinegar)FDA LinkGeneric
4. 1-phenyl-3,3-dimethyltriazene (PDT)IBA
5. beta Carotene (Betacarotene)FDA Link
6. Papillomavirus Vaccines (HPV Vaccines)IBA
7. Fluorouracil (Carac)FDA LinkGeneric
8. Biological Markers (Surrogate Marker)IBA
9. Proteins (Proteins, Gene)IBA
10. AntigensIBA

Therapies and Procedures

1. Laser Therapy (Surgery, Laser)
2. Lasers (Laser)
3. Gas Lasers
4. Cryotherapy (Therapy, Cold)
5. Aftercare (After-Treatment)