Gelsolin

A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.

Also Known As:

Networked: 685 relevant articles (14 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kiuru-Enari, Sari: 26 articles (10/2021 - 06/2002)
2.	Stossel, Thomas P: 13 articles (02/2021 - 01/2002)
3.	DiNubile, Mark J: 11 articles (05/2022 - 01/2002)
4.	Bucki, Robert: 11 articles (01/2022 - 12/2008)
5.	Atula, Sari: 9 articles (10/2021 - 01/2015)
6.	Gettemans, Jan: 9 articles (01/2019 - 12/2002)
7.	Kelly, Jeffery W: 9 articles (10/2013 - 11/2003)
8.	Janmey, Paul A: 8 articles (04/2020 - 12/2008)
9.	Ji, Lina: 8 articles (07/2017 - 03/2008)
10.	Lee, Po-Shun: 8 articles (01/2016 - 03/2006)

Related Diseases

1.	Inflammation (Inflammations) 08/01/2022 - "Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse experimental models of infectious and noninfectious inflammation. " 06/01/2020 - "The plasma gelsolin levels were decreased in PsA patients, suggesting that gelsolin may be implicated in the chronic joint inflammation process. " 01/01/2020 - "Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. " 01/01/2018 - "Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation." 01/01/2017 - "Gelsolin (GSN) is involved in the process of inflammation. "
2.	Stroke (Strokes) 11/02/2011 - "The protective effects of plasma gelsolin on stroke outcome in rats." 01/16/2013 - "Gelsolin improved the prognostic value of National Institutes of Health Stroke Scale score for 6-month unfavorable outcome, but not for 6-month mortality. " 01/16/2013 - "The prognostic value of gelsolin was similar to that of National Institutes of Health Stroke Scale score for 6-month clinical outcomes. " 01/16/2013 - "Plasma gelsolin level was highly correlated with National Institutes of Health Stroke Scale score. " 12/01/2011 - "Plasma gelsolin level in stroke patients was significantly decreased compared with healthy controls. "
3.	Neoplasms (Cancer) 01/01/2016 - " study therefore identified gelsolin as a novel regulator of intracellular O2.- in cancer cells via interacting with Cu/ZnSOD and inhibiting its enzymatic activity. " 11/01/2007 - "The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 and gelsolin. " 10/01/2004 - "High level gelsolin expression and variable gelsolin expression are adverse prognostic factors for NSCLC in this study, which might manifest the high motility and heterogeneity of tumor cells, two distinguishing characteristics for tumors with potentially enhanced invasive and dissemination capabilities." 11/01/2022 - "Gelsolin expression is significantly associated with tumor stage, tumor grade, and locoregional recurrence. " 01/01/2021 - "Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity."
4.	Amyloidosis 05/01/2015 - "Insertion of the therapeutic nanobody gene into the gelsolin amyloidosis mouse genome resulted in improved muscle contractility. " 01/01/2020 - "Finnish gelsolin amyloidosis causes significant disease burden but does not affect survival: FIN-GAR phase II study." 12/01/2018 - "In this study, we report a case of Finnish gelsolin amyloidosis (FGA) in a Chinese family. " 01/01/2017 - "Asn211Lys gelsolin mutation on mass spectrometry studies was detected in three patients by mass spectrometry, which appears to represent a renal-limited form of gelsolin amyloidosis. " 12/01/2023 - "A novel p.Y474H gelsolin variant featured a unique clinical phenotype that differed from the one associated with the most common variant of AGel amyloidosis. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "Low level of Gelsolin was found in metastatic patients (p=0.002) and patients who died from breast cancer (P=0.03) compared to disease free patients at final follow up. " 01/01/2013 - "This study aimed to investigate the germline mutations and expressional profile of Gelsolin in human breast cancer tissues. " 10/01/2015 - "To determine its effect on migration, gelsolin expression was down-regulated as well as overexpressed in breast cancer cell lines. " 01/01/2015 - "Further analyses, performed using a panel of breast cancer cell lines, allowed us to further elucidate the signaling network that might modulate the expression of gelsolin in breast cancer." 01/01/2013 - "Gelsolin transcript level was found significantly lower in breast tumor tissues compared to control samples (p=0.03). "

Related Drugs and Biologics

1.	Complementary DNA (cDNA)
2.	Proteins (Proteins, Gene)
3.	Peptides (Polypeptides)
4.	DNA (Deoxyribonucleic Acid)
5.	Blood Proteins (Serum Proteins)
6.	Vitamin D-Binding Protein
7.	Cytokines
8.	Diclofenac (SR 38)
9.	Carrageenan
10.	Amyloid (Amyloid Fibrils)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Mechanical Ventilators (Ventilator)
4.	Aftercare (After-Treatment)
5.	Renal Dialysis (Hemodialysis)