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Adenomatous Polyps

Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
Also Known As:
Adenomatous Polyp; Polyp, Adenomatous; Polyps, Adenomatous
Networked: 571 relevant articles (13 outcomes, 111 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Colorectal Neoplasms (Colorectal Cancer)
2. Polyps
3. Adenoma (Adenomas)
4. Adenomatous Polyps
5. Neoplasms (Cancer)

Experts

1. Goel, Ajay: 6 articles (04/2012 - 02/2003)
2. Boland, C Richard: 5 articles (04/2012 - 02/2003)
3. Veysey, Martin: 4 articles (12/2015 - 08/2011)
4. Boyd, Lyndell: 4 articles (12/2015 - 08/2011)
5. Lucock, Mark: 4 articles (12/2015 - 08/2011)
6. MaƂecka-Panas, Ewa: 4 articles (01/2013 - 05/2007)
7. Bresalier, Robert S: 4 articles (04/2012 - 09/2004)
8. Brenner, Dean E: 4 articles (04/2012 - 05/2004)
9. Arber, Nadir: 4 articles (03/2012 - 08/2006)
10. Schatzkin, Arthur: 4 articles (01/2011 - 11/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adenomatous Polyps:
1. Biological Markers (Surrogate Marker)IBA
2. celecoxib (Celebrex)FDA Link
3. rofecoxib (Vioxx)FDA Link
11/15/2008 - "The Adenomatous Polyp Prevention on Vioxx (APPROVe) study assessed the effect of 3-year treatment with a cyclo-oxygenase-2 inhibitor, rofecoxib (25 mg), on recurrence of neoplastic polyps of the large bowel. "
04/01/2009 - "In 2004 and 2005, predictions of some pharmacologists were confirmed when the Adenomatous Polyp Prevention on VIOXX trial (APPROVE) and other randomized, double-blind, placebo-controlled trials with COX-2 inhibitors showed an increased rate of thrombotic vascular events, including myocardial infarction, in patients treated with coxibs. "
03/01/2007 - "We performed adjusted indirect comparison of celecoxib versus rofecoxib for cardiovascular events using two data on The Adenomatous Polyp Prevention on Vioxx (APPROVe) trial and Adenoma Prevention with Celecoxib (APC) trial. "
01/01/2007 - "Three large trials using celecoxib (the Adenoma Prevention with Celebrex and the Prevention of Spontaneous Adenomatopus Polyps) or refecoxib (the Adenomatous Polyp Prevention on Vioxx) for the recurrence of colorectal polyps in patients with a history of colorectal adenoma polypectomized confirmed chemopreventive effects on colorectal adenoma but two of three trails alerted us a hazard of cardiovascular (CV) events. "
12/01/2006 - "In the more common sporadic setting, the Adenomatous Polyp PRevention On Vioxx (rofecoxib), Adenoma Prevention with Celecoxib and Prevention of Sporadic Adenomatous Polyps (celecoxib) trials have demonstrated a significant reduction in adenoma recurrence, but important concerns were raised regarding cardiovascular toxicity associated with selective cyclo-oxygenase-2 inhibitors. "
4. Sulindac (Copal)FDA LinkGeneric
5. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
6. Dietary CalciumIBA
7. Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
8. BariumIBA
9. GuaiacIBA
05/15/2011 - "A higher detection rate for colorectal cancer and advanced adenomatous polyp for screening with immunochemical fecal occult blood test than guaiac fecal occult blood test, despite lower compliance rate. "
11/27/2015 - "1) use of Guaiac and/or immunochemical fecal occult blood test as screening-tests for the detection of colorectal cancer and/or colon polyps (1 cm or more in diameter) in people older than 45 years; 2) comparing of results with the results of colonoscopy (colonoscopy is counted by majority of the authors as a "gold standard" for the diagnosis of CRC and adenomatous polyps). "
10/03/2007 - "One type of fecal occult blood test (FOBT), the unrehydrated guaiac fecal occult blood test (GT), is recommended by the United States Preventive Services Task Force and the Institute of Medicine for use in screening programs, but it has relatively low sensitivity as a single test for detecting advanced colonic neoplasms (cancer and adenomatous polyps > or = 1 cm in diameter). "
05/01/1988 - "From 1979 to 1982, 1233 symptom-free subjects at high risk for colon cancer because of family history and/or personal history of bowel neoplasia (cancer or adenomatous polyp) were examined with a guaiac test (Hemoccult II) for occult blood in stools. "
04/01/1983 - "Contrary to statements in standard texts as to the high sensitivity of guaiac-impregnated cards for the detection of these tumors, our results demonstrate only a 52% sensitivity for colorectal carcinoma and a 23% sensitivity for adenomatous polyps over 1.0 cm in diameter. "
10. VitaminsIBA

Therapies and Procedures

1. Chemoprevention
2. Enema (Enemas)
3. Surgical Instruments (Clip)
4. Appendectomy
5. Sigmoidoscopes