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Oxyphilic Adenoma (Oncocytoma)

A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Also Known As:
Oncocytoma; Adenoma, Oxyphilic; Huerthle Cell Tumor; Hurthle Cell Tumor
Networked: 356 relevant articles (8 outcomes, 27 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Renal Cell Carcinoma (Grawitz Tumor)
2. Neoplasms (Cancer)
3. Angiomyolipoma
4. Carcinogenesis
5. Adenoma (Adenomas)

Experts

1. Amin, Mahul B: 6 articles (10/2022 - 01/2005)
2. Ellinger, Jörg: 6 articles (11/2021 - 11/2010)
3. Fries, Jochen W U: 5 articles (01/2022 - 05/2012)
4. Yang, Ximing J: 5 articles (05/2010 - 03/2005)
5. Moch, Holger: 4 articles (10/2022 - 01/2005)
6. Reuter, Victor E: 4 articles (01/2020 - 03/2004)
7. Duddalwar, Vinay A: 4 articles (12/2018 - 10/2015)
8. Gill, Inderbir S: 4 articles (12/2018 - 10/2015)
9. Büttner, Reinhard: 4 articles (01/2015 - 11/2010)
10. Kahl, Philip: 4 articles (01/2015 - 11/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Oxyphilic Adenoma:
1. VimentinIBA
2. LipidsIBA
3. ParaffinIBA
4. MicroRNAs (MicroRNA)IBA
5. Caveolin 1IBA
6. CatecholaminesIBA
7. Antihypertensive Agents (Antihypertensives)IBA
8. Imatinib Mesylate (Gleevec)FDA Link
9. Proteins (Proteins, Gene)FDA Link
10. Cadherins (E-Cadherin)IBA
08/01/2012 - "To evaluate retrospectively kidney-specific cadherin (Ksp-cad) expression in renal cell carcinoma (RCC) subtypes and oncocytoma in correlation with its ontogenetic origin of distal and proximal tubules and to correlate Ksp-cad expression with tumour characteristics. "
07/01/2006 - "Kidney-specific cadherin (Ksp-cad) recently was proposed to differentiate chromophobe renal cell carcinoma (RCC) from oncocytoma based on a finding of Ksp-cad expression in 97% of chromophobe RCCs but only 3% of oncocytomas. "
01/01/2011 - "Kidney-specific cadherin, parvalbumin, claudin-7, and claudin-8 are sensitive markers for renal neoplasms from distal portions of the nephron, including chromophobe RCC and oncocytoma. "
01/01/2007 - "Immunohistochemical study (using EnVision method) for Ksp-cadherin, CD10, vimentin, epithelial membrane antigen and CK7 was carried out in normal human kidney samples, as well as in 166 cases of primary renal neoplasms (including 120 cases of clear cell renal cell carcinoma (RCC), 20 cases of papillary RCC (type I papillary RCC 15 cases and type II papillary RCC 5 cases), 18 cases of chromophobe RCC and 8 cases of oncocytoma). "
01/01/1998 - "Cryosections of 58 thyroid tissue specimens from normal tissue, thyrotoxicosis, nodular goiter, oxyphilic adenoma, follicular adenoma, follicular carcinoma, papillary carcinoma and anaplastic carcinoma, and three lymph node metastases were investigated immunohistochemically using monoclonal antibodies specifically recognizing the integrin beta1-, beta4-, alpha1-, alpha2-, alpha3-, alpha5- and alpha6-subunits, or E-cadherin. "

Therapies and Procedures

1. Adrenalectomy
2. Therapeutics
3. Nephrectomy
4. Radiotherapy
5. Renal Dialysis (Hemodialysis)