Liver Cell Adenoma (Hepatocellular Adenoma)

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317 relevant articles (4 outcomes, 14 trials/studies) found for this Disease

Description: A benign epithelial tumor of the LIVER.

Also Known As:

Hepatocellular Adenoma; Adenoma, Liver Cell; Adenomas, Hepatocellular; Adenomas, Liver Cell; Benign Hepatoma; Benign Hepatomas; Hepatocellular Adenomas; Hepatomas, Benign; Liver Cell Adenomas; Adenoma, Hepatocellular; Hepatoma, Benign

Relationship Network

Disease Context: Research Results

Neoplasms: 386513

Neoplasms by Histologic Type: 1

Glandular and Epithelial Neoplasms: 238

Adenoma: 11032

Liver Cell Adenoma: 317

Neoplasms by Site: 1

Digestive System Neoplasms: 52

Liver Neoplasms: 3392

Liver Cell Adenoma: 317

Digestive System Diseases: 29

Liver Diseases: 19043

Liver Neoplasms: 3392

Liver Cell Adenoma: 317

Digestive System Neoplasms: 52

Liver Neoplasms: 3392

Liver Cell Adenoma: 317

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma)
2.	Neoplasms (Cancer)
3.	Adenoma (Adenomas)
4.	Carcinoma (Carcinomatosis)
5.	Focal Nodular Hyperplasia
79 Diseases and 213 more articles analyzed in the Research Interface, order at left...

Experts

1.	Zucman-Rossi, Jessica: 2 articles (05/2007 - 03/2007)
2.	Bioulac-Sage, Paulette: 2 articles (05/2007 - 03/2007)
3.	Ito, Yuki: 1 article (03/2008)
4.	Nakajima, Tamie: 1 article (03/2008)
5.	Gonzalez, Frank J: 1 article (03/2008)
6.	Takashima, Kayoko: 1 article (03/2008)
7.	Rangheard, A-S: 1 article (02/2008)
8.	Pelletier, G: 1 article (02/2008)
9.	Fabre, M: 1 article (02/2008)
10.	Buffet, C: 1 article (02/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Liver Cell Adenoma:

1.	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 03/01/2001 - "Between 53 and 79 weeks of age, 39% of rats receiving N-nitrosodiethylamine alone developed multiple (1.5 +/- 0.8) hepatocellular adenomas" 09/01/1992 - "Progressive atypia in spontaneous and N-nitrosodiethylamine-induced hepatocellular adenomas of C3H/HeNCr mice." 09/01/1995 - "Chemoprevention of diethylnitrosamine-induced liver foci and hepatocellular adenomas in C3H mice." 04/01/1991 - "Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine." 05/01/1988 - "Animals were sacrificed at either 52 or 78 wk. PB and EPH significantly enhanced the development of hepatocellular foci and hepatocellular adenomas at 52 wk and hepatocellular carcinomas at 78 wk in N-nitrosodiethylamine-initiated rats" Get all the results and reference details, order at left...
2.	Phenobarbital (Luminal)FDA Link 03/01/2001 - "Multiplicities of hepatocellular adenomas were significantly greater than the control value in rats fed 1,500 ppm DPH or 500 ppm phenobarbital (5.9 +/- 4.8 and 10.1 +/- 6.7, respectively), but not in the rats receiving 500 ppm DPH (2.3 +/- 1.6)" 04/01/2003 - "Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital]" 05/01/1991 - "Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice" 01/01/1996 - "Chronic exposure to high doses of phenobarbital (PB) causes hepatocellular adenomas in both mice and rats and hepatocellular carcinomas in some strains of mice" 11/01/1986 - "sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype" Get all the results and reference details, order at left...
3.	Ethanol (Ethyl Alcohol)IBA 01/01/2005 - "Ethanol induced a dose-dependent trend in hepatocellular adenoma or carcinoma in male mice, with the incidence being marginally increased at the highest dose" 01/01/2001 - "We report a 20-year-old man with glycogen storage disease type Ia (GSD Ia) who presented multiple hepatocellular adenomas (HCAs) in 1993 and in whom percutaneous ethanol injection (PEI) was conducted as treatment for some enlarging tumors beneath the liver surface" 05/01/1991 - "The incidence of hepatocellular adenomas in the groups given 10 mg ethyl carbamate/kg was, as shown by chi-square analysis, significantly reduced by the ethanol and wine treatments" 05/01/1991 - "Both ethanol and wine treatments reduced the incidence of lung Clara-cell adenomas in mice given 10 mg ethyl carbamate/kg and reduced the frequency (number of specific tumours/number of tumour-bearing mice) of both Clara-cell adenomas in mice given 10 mg ethyl carbamate/kg and of alveolar adenomas in mice given 20 mg ethyl carbamate/kg. Wine treatments also reduced the frequency of hepatocellular adenomas compared with those of other treatment groups, and no hepatocellular carcinomas developed in any of the groups given wine, even with the 20-mg/kg ethyl carbamate dose" Get all the results and reference details, order at left...
4.	Urethane (Ethyl Carbamate)IBA 05/01/1991 - "The incidence of hepatocellular adenomas in the groups given 10 mg ethyl carbamate/kg was, as shown by chi-square analysis, significantly reduced by the ethanol and wine treatments" 05/01/1991 - "Both ethanol and wine treatments reduced the incidence of lung Clara-cell adenomas in mice given 10 mg ethyl carbamate/kg and reduced the frequency (number of specific tumours/number of tumour-bearing mice) of both Clara-cell adenomas in mice given 10 mg ethyl carbamate/kg and of alveolar adenomas in mice given 20 mg ethyl carbamate/kg. Wine treatments also reduced the frequency of hepatocellular adenomas compared with those of other treatment groups, and no hepatocellular carcinomas developed in any of the groups given wine, even with the 20-mg/kg ethyl carbamate dose" Get all the results and reference details, order at left...
5.	Triprolidine (Actidil)FDA LinkGeneric 04/01/1995 - "While there was a positive dose response trend for hepatocellular adenomas in males the combination of these and hepatocellular carcinomas eliminated the significant trend, and it was concluded that there was no evidence of a carcinogenic response to triprolidine in B6C3F1 mice.(ABSTRACT TRUNCATED AT 250 WORDS)" Get all the results and reference details, order at left...
6.	hydroquinone (Black and White)FDA Link 01/01/1993 - "All surviving animals were killed at the end of week 40 when histopathological assessment revealed significant reduction of the numbers per rat of hepatocellular adenomas and hepatocellular carcinomas by resorcinol, whereas hydroquinone significantly enhanced the numbers per rat of renal microadenomas and renal cell tumors" Get all the results and reference details, order at left...
7.	resorcinol (resorcin)IBA 01/01/1993 - "All surviving animals were killed at the end of week 40 when histopathological assessment revealed significant reduction of the numbers per rat of hepatocellular adenomas and hepatocellular carcinomas by resorcinol, whereas hydroquinone significantly enhanced the numbers per rat of renal microadenomas and renal cell tumors" Get all the results and reference details, order at left...
8.	Oral ContraceptivesIBA 03/01/1990 - "Of the nine epidemiologic controlled studies reporting on the relationship between oral contraceptives use and hepatic tumours, three have findings specifically on the association of oral contraceptives use and hepatocellular adenomas" 12/01/1976 - "Electron microscopic study of benign hepatoma in a patient on oral contraceptives." 02/26/1976 - "During the past six years an increasing number of liver-cell adenomas in women were diagnosed, and we undertook a study of possible etiologic factors, including use of oral contraceptives, in 42 women" 06/16/2007 - "The withdrawal of oral contraceptives is the first recommendation after a diagnosis of hepatocellular adenoma is made, which is often followed by regression of the tumour" 01/01/2005 - "During the last three decades liver cell adenoma and liver cell adenomatosis have emerged as new clinical entities in hepato-logical practice due to the widespread use of oral contraceptives and increased imaging of the liver" Get all the results and reference details, order at left...
9.	PPAR alphaIBA 03/01/2008 - "Taken together, DEHP may induce hepatocellular adenomas, in part, via suppression of G2/M arrest regulated by Gadd45a and caspase 3-dependent apoptosis in Ppar alpha-null mice, but these genes may not be involved in tumorigenesis in the wild-type mice" 03/01/2008 - "The microarray profiles showed that the up- or down-regulated genes were quite different between hepatocellular adenoma tissues of wild-type and Ppar alpha-null mice exposed to DEHP" 03/01/2008 - "Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice." 03/01/2008 - "The gene expressions of apoptotic peptidase activating factor 1 (Apaf1) and DNA-damage-inducible 45 alpha (Gadd45a) were increased in the hepatocellular adenoma tissues of wild-type mice exposed to DEHP, whereas they were unchanged in corresponding tissues of Ppar alpha-null mice" 03/01/2008 - "A recent study revealed that long-term exposure to relatively low-dose DEHP (0.05%) caused liver tumors including hepatocellular carcinomas, hepatocellular adenomas, and chologiocellular carcinomas at a higher incidence in Ppar alpha-null mice (25.8%) than in wild-type mice (10.0%)" Get all the results and reference details, order at left...
10.	DNA (Deoxyribonucleic Acid)IBA 05/01/2005 - "We observed (1) earlier appearance of putative preneoplastic foci (PPF), hepatocellular adenoma (HCA), and carcinoma (HCC) in C3H/He than in C57Bl/6J mice and (2) an increase of hepatocellular DNA synthesis in C3H/He and C57Bl/6J mice, compared to normal liver, via PPF and HCA to HCC" 05/01/2000 - "Comparison of the DNA content in liver cell adenoma, hepatocellular carcinoma and regenerative nodules." 01/01/1986 - "All rat tumors tested failed to yield activated oncogenes (0/29), whereas 30% (3/10) of mouse hepatocellular adenomas and 77% (10/13) of hepatocellular carcinomas scored positive by DNA transfection" 03/01/1989 - "Southern blot analysis showed that NIH 3T3 transformants induced by DNA from 5 HCCs, 1 hepatocellular adenoma, 1 cholangioma, 1 histiocytic sarcoma, and 1 thyroid carcinoma contained an activated K-ras gene of rat origin" 08/01/2002 - "METHODS: After microdissection, DNA from 25 liver cell adenomas and corresponding normal liver tissue were analysed for INK4-ARF inactivation by DNA sequence analysis, methylation specific polymerase chain reaction, restriction enzyme related-polymerase chain reaction (RE-PCR), mRNA expression, microsatellite analysis, and immunohistochemistry" Get all the results and reference details, order at left...
211 Drugs and Important Bio-Agents and 296 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Liver Transplantation 03/01/1995 - "The aim of this report is to describe the indications, feasibility, and outcome of liver transplantation for hepatocellular adenomas" 03/01/1995 - "Liver transplantation for treatment of giant hepatocellular adenomas." 01/01/1998 - "This retrospective analysis deals with 58 patients who underwent surgery for hepatocellular adenoma: resection of different extension: n = 54, liver transplantation n = 4. In 39.6% of the patients the tumor was an incidental finding" 03/01/1995 - "A 66-year-old man with a 17-cm hepatocellular adenoma originating in the left lobe but involving nearly the entire liver and a 35-year-old woman with a 20-cm tumor involving the right lobe of the liver and compressing the left lobe underwent liver transplantation without complication" 01/11/2001 - "Liver resection and liver transplantation in liver cell adenoma, hepatocellular carcinoma and fibrolamellar liver carcinoma]" Get all the results and reference details, order at left...
2.	Contraception (Birth Control) 12/01/2006 - "Here we report the case of a 37-year-old FAP woman presenting a hepatocellular adenoma after oestroprogestative oral contraception use" 02/01/1999 - "Multiple hepatocellular adenomas in a patient with a history of oral contraception." 11/01/1995 - "The regression of a hepatocellular adenoma after the withdrawal of hormonal contraception]" 10/05/1992 - "Hepatocellular adenoma after oral contraception]" 01/01/1977 - "The association between oral contraception and hepatocellular adenoma--a preliminary report." Get all the results and reference details, order at left...
3.	Hepatectomy 07/01/2007 - "Right hepatectomy with anterior approach for ruptured liver cell adenoma." 12/15/1984 - "Successful pregnancy following partial hepatectomy for removal of hepatocellular adenomas." 03/01/1961 - "Partial hepatectomy for benign hepatoma" 08/01/2004 - "To examine the potential inhibitory effects of a novel liver-selective thyromimetic, KAT-681 (KAT), on the development of hepatocellular proliferative lesions, male F344 rats were given a single intraperitoneal injection of 150 mg/kg diethylnitrosamine (DEN), followed by gavage administration of 7.5 mg/kg per day of 2-acetylaminofluorene (2-AAF) twice daily from weeks 2 to 4 with partial hepatectomy (PH) at week 3. From 5 weeks after the completion of 2-AAF administration, the rats were orally dosed with 0.04, 0.1, or 0.25 mg/kg per day KAT for 3 weeks, and subjected to morphometric analysis of the induced glutathione S-transferase placental form (GST-P)-positive lesions and hepatocellular adenomas (HCAs)" Get all the results and reference details, order at left...
4.	Islets of Langerhans Transplantation 08/01/2005 - "NNM treatment after low-number islet transplantation resulted in an increase in the number of preneoplastic hepatocellular foci, and a significant increase in the number and an earlier appearance of hepatocellular adenomas and carcinomas compared with controls" 01/01/2000 - "Indeed, the altered hepatocytes after low-number islet transplantation proceeded in long-term experiments to hepatocellular adenomas and hepatocellular carcinomas" Get all the results and reference details, order at left...
5.	Transplantation (Transplant Recipients) 04/01/1993 - "Liver cell adenoma at the age of 3 years and transplantation 19 years later after development of carcinoma: a case report." 03/01/1997 - "Glycogen-storing foci (which were the first parenchymal alteration observed some days after transplantation) persisted at least for 6 months, when the first mixed-cell foci and the first hepatocellular adenoma emerged" Get all the results and reference details, order at left...
13 Therapies and Procedures and 30 more articles analyzed in the Research Interface, order at left...

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