|5.||Hyperaldosteronism (Conn Syndrome)
|1.||Sasano, Hironobu: 11 articles (01/2015 - 08/2003)|
|2.||Bertherat, Jérôme: 8 articles (09/2015 - 08/2003)|
|3.||Bertagna, Xavier: 8 articles (09/2015 - 08/2003)|
|4.||Suzuki, Takashi: 7 articles (12/2009 - 08/2003)|
|5.||Groussin, Lionel: 6 articles (09/2015 - 08/2003)|
|6.||Tissier, Frédérique: 6 articles (09/2015 - 09/2005)|
|7.||Mete, Ozgur: 5 articles (06/2015 - 01/2009)|
|8.||Stratakis, Constantine A: 5 articles (01/2015 - 06/2002)|
|9.||Fassnacht, Martin: 5 articles (01/2014 - 01/2005)|
|10.||Allolio, Bruno: 5 articles (01/2014 - 01/2005)|
09/01/2006 - "The aldosterone-producing adenoma (Conn's syndrome) is primarily cured by operation, in most cases performed endoscopically. "
04/01/2004 - "Further studies demonstrated an enlarged left superior parathyroid gland and a left aldosterone-producing adrenocortical adenoma. "
01/01/2009 - "Oncocytes also exhibited numerous eosinophilic intracytoplasmic globular inclusions, which are not commonly observed in aldosterone-producing adrenal cortical adenomas. "
01/01/2009 - "Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions."
11/01/2007 - "Localization of aldosterone-producing adrenocortical adenomas: significance of adrenal venous sampling."
|2.||Amiloride (Midamor)FDA LinkGeneric
|3.||Hydrocortisone (Cortisol)FDA LinkGeneric
06/01/2013 - "The objective of the study was to identify the gene expression profile associated with the autonomous and excessive cortisol secretion of adrenocortical adenomas. "
06/01/2007 - "The objective of the study was to analyse the androgen-producing ability of cortisol-secreting adrenocortical adenomas. "
10/01/2015 - "In this review, the role of cAMP/PKA signaling in the regulation of adrenocortical cell function and its alterations in cortisol-producing adrenocortical adenomas will be summarized, with particular focus on recent developments. "
09/01/2015 - "Steroid Profiling by LC-MS/MS in Nonsecreting and Subclinical Cortisol-Secreting Adrenocortical Adenomas."
09/01/2015 - "The 10 Hounsfield units unenhanced computed tomography attenuation threshold does not apply to cortisol secreting adrenocortical adenomas."
|4.||Spironolactone (Aldactone)FDA LinkGeneric
02/01/1996 - "The efficacy of spironolactone on blood pressure (BP) was positive in 81.8% of Group 1 and 16.7% of Group 2. Adrenal cortical adenoma in 24 cases with a cure rate of 70.8% (17/24) and adrenal cortical macronodular hyperplasia in 6 cases with a cure rate of 33.3% (2/6) were noted. "
03/20/1993 - "Pathological studies revealed adrenocortical adenoma cells of clear cell type with spironolactone bodies in the bilateral adrenal tumors. "
01/01/1982 - "So-called Spironolactone bodies are reported in four adrenal cortical adenomas that were removed from patients with primary hyperaldosteronism, treated preoperatively with spironolactone. "
01/01/2014 - "A spectrum of histologic and ultrastructural findings were encountered within an adrenal cortical adenoma from a patient treated with both spironolactone and eplerenone. "
01/01/1990 - "A case of testosterone-secreting adrenal cortical adenoma with spironolactone body-like inclusion."
|5.||Acetic Acid (Vinegar)FDA LinkGeneric
11/01/1999 - "Our preliminary results suggest that percutaneous acetic acid injection is a safe and effective alternative for treatment of small functional adrenal cortical adenoma."
12/01/2003 - "CT-guided percutaneous acetic acid injection might be a simple, cost-effective, and far less invasive treatment for small functioning adrenocortical adenomas."
12/01/2003 - "We reported the outcomes of computed tomography (CT)-guided percutaneous acetic acid injection therapy for functioning adrenocortical adenomas. "
12/01/2003 - "Computed tomography-guided percutaneous acetic acid injection therapy for functioning adrenocortical adenoma."
11/01/1999 - "Small functional adrenal cortical adenoma: treatment with CT-guided percutaneous acetic acid injection--report of three cases."
|7.||Adrenocorticotropic Hormone (ACTH)FDA Link
04/01/1999 - "No reports have yet precisely determined corticotropin (ACTH) responsiveness in virilizing adrenocortical adenoma. "
01/01/1978 - "[Response to ACTH of human adrenocortical cells isolated from normal glands and from adrenocortical adenoma (author's transl)]."
11/01/1977 - "ACTH sensitive murine adrenocortical adenoma cells (Y-1) were examined by transmission and scanning electron microscopes under non-stimulated and stimulated conditions. "
05/01/2005 - "Aim of this study was to investigate the presence of such genetic alterations on a series of 10 ACTH-independent Cushing syndrome due to non-PPNAD adrenocortical adenomas. "
01/01/2014 - "Metachronous bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome is a surgical case that scarcely occurs. "
|8.||Messenger RNA (mRNA)IBA
02/01/2013 - "Survivin mRNA and protein expression was assessed in adrenal tissue specimens [by real-time-PCR in 29 ACC, 24 adrenocortical adenomas (ACA) and 12 normal adrenal glands; by immunohistochemistry in 167 ACCs, 15 ACA, and 5 normal adrenal glands]. "
12/01/1997 - "The average concentration of ADM mRNA in the hormonally active adrenocortical adenomas was about 80% and 7% of that in normal adrenal glands and separated adrenal medulla respectively. "
11/01/1997 - "First, the ERV3 mRNA was demonstrated at different levels in organs, and at consistently high levels in adrenal glands from all individuals and in all adrenocortical adenomas examined, by Northern hybridization. "
03/16/1992 - "The rank order of the binding to the receptor expressed in COS-7 cells was Ang II greater than Ang III greater than Ang I. The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis."
09/15/2001 - "Based on the results of RT-PCR and Western blot analysis, both MEN1 mRNA and menin protein appeared to be highly expressed in Cushing syndrome resulting from adrenocortical adenomas and carcinoma. "
11/01/1997 - "Immunoreactivity of all the enzymes was intense in the compact cells of the right adrenocortical adenoma, while the adjacent non-neoplastic cortex was negative for the enzymes. "
01/01/2005 - "Histopathological examination of the resected specimen revealed an adrenocortical adenoma predominantly composed of eosinophilic tumor cells expressing all the steroidogenic enzymes. "
04/01/1999 - "Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor."
06/01/2008 - "Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas."
06/01/2003 - "Hyperfunctioning adrenocortical adenomas produce excessive amounts of various corticosteroids due to dysregulated expression of steroidogenic enzymes. "
07/01/2003 - "51 of 61(83.6%) adrenocortical adenomas reacted with inhibin alpha. "
07/01/2003 - "To evaluate the potential diagnostic role of A103 and inhibin alpha in adrenocortical adenoma and the feasibility of tissue microarray/tissue chips. "
07/01/2003 - "[The expression of A103 and inhibin alpha in adrenocortical adenoma by high-throughput tissue microarray techniques]."
03/01/1995 - "These findings indicated that normal adrenal glands and adrenocortical adenomas produced and secreted inhibin-LI into the general circulation in vivo and Cs adenomas have relatively high capacity for secreting inhibin-LI, and the present study provided the first in vivo evidence for adrenal inhibin-LI production in pathological conditions."
06/01/2004 - "Fifty of the 66 (75.8%) adrenocortical adenomas, 28 of the 37 (75.7%) adrenocortical carcinomas were positive for inhibin-alpha. "
01/01/2011 - "Laparoscopic right adrenalectomy was performed and adrenal cortical adenoma was diagnosed on a histological study."
01/01/2012 - "Then two weeks after delivery open right adrenalectomy was carried out without any complications and in the histopathological evaluation benign adrenocortical adenoma was reported. "
10/01/2011 - "No hypersecreting lesions were confirmed during follow-up; one patient underwent adrenalectomy for a suspected phaeochromocytoma (adrenocortical adenoma at histopathology). "
02/01/2011 - "As a result of diagnosing CS after delivery, an adrenal cortical adenoma of the right adrenal gland was demonstrated and a laparoscopic adrenalectomy was successfully performed."
02/01/2010 - "In the fourth patient with adrenocortical adenoma, ablation was carried out owing to the cardiopulmonary instability of the patient during attempted laparoscopic adrenalectomy. "
|2.||Drug Therapy (Chemotherapy)
11/01/2002 - "As a control, normal adrenal tissue from 3 nephrectomy specimens was included in the study, as was tissue from 1 adrenocortical adenoma. "
03/01/2003 - "Four years before, nephrectomy and adrenalectomy had been performed for a renal cell carcinoma with metastasis in a coexistent adrenocortical adenoma. "