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Placental Site Trophoblastic Tumor

An uncommon variant of CHORIOCARCINOMA. It is composed almost entirely of mononuclear cytotrophoblasts (TROPHOBLASTS). Because its secretion of hCG (CHORIONIC GONADOTROPIN) is low, a large tumor may develop before the hCG can be detected.
Also Known As:
Trophoblastic Tumor, Placental Site; Trophoblastic Tumor, Placental; Placental Trophoblastic Tumor; Placental Trophoblastic Tumors; Placental-Site Trophoblastic Tumors; Trophoblastic Tumor, Placental-Site; Trophoblastic Tumors, Placental; Trophoblastic Tumors, Placental-Site; Tumor, Placental Trophoblastic; Tumor, Placental-Site Trophoblastic; Tumors, Placental Trophoblastic; Tumors, Placental-Site Trophoblastic; Placental-Site Trophoblastic Tumor
Networked: 114 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Choriocarcinoma
2. Trophoblastic Neoplasms (Trophoblastic Tumor)
3. Hydatidiform Mole (Molar Pregnancy)
4. Neoplasms (Cancer)
5. Neoplasm Metastasis (Metastasis)

Experts

1. Berkowitz, Ross S: 3 articles (05/2012 - 05/2002)
2. Cheung, Annie N Y: 3 articles (05/2011 - 04/2006)
3. Cole, Laurence A: 3 articles (01/2009 - 08/2006)
4. Piura, B: 3 articles (01/2007 - 01/2006)
5. Yamamoto, Hidemi: 2 articles (05/2012 - 07/2011)
6. Nagymanyoki, Zoltan: 2 articles (05/2012 - 07/2011)
7. Fulop, Vilmos: 2 articles (05/2012 - 07/2011)
8. Kindelberger, David: 2 articles (05/2012 - 07/2011)
9. Ng, Shu-Wing: 2 articles (05/2012 - 07/2011)
10. Fichorova, Raina: 2 articles (05/2012 - 07/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Placental Site Trophoblastic Tumor:
1. Methotrexate (Mexate)FDA LinkGeneric
06/01/2012 - "Eighteen patients were treated with EP-EMA, either as first-line chemotherapy for high-risk gestational trophoblastic neoplasia (n = 6), placental site trophoblastic tumor (n = 1), or as salvage chemotherapy for gestational trophoblastic neoplasia after single-agent methotrexate (methotrexate, 1 mg/kg, on days 1, 3, 5, and 7 every two weeks) (n = 10) or high-dose methotrexate-etoposide: methotrexate, 1000 mg/m, on day 1; etoposide, 100 mg/m, on days 1 to 2, every week) (n = 1). "
05/01/1991 - "Seventeen patients with low- or medium-risk gestational trophoblastic tumors (GTT) and one patient with a placental-site trophoblastic tumor were treated according to an 8-day schedule of low-dose methotrexate (LDMTX) alternating with citrovorum factor (CF). "
01/01/1998 - "We document a case of long-term remission in a patient with metastatic placental site trophoblastic tumor (PSTT) and attempt to determine the response rate of metastatic PSTT to EMA/CO (etoposide, methotrexate, actinomycin-D, cyclophosphamide, and vincristine) combination chemotherapy based on available reports. "
02/01/2000 - "Etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors."
02/01/2000 - "To evaluate the results of etoposide, cisplatin/etoposide, methotrexate, and actinomycin D (EP/EMA) chemotherapy in patients with gestational trophoblastic tumors (GTTs), who have relapsed after or who have become refractory to EMA/cyclophosphamide and vincristine (CO) chemotherapy, and in patients presenting with metastatic placental site trophoblastic tumors (PSTTs). "
2. Etoposide (VP 16)FDA LinkGeneric
06/01/2012 - "Eighteen patients were treated with EP-EMA, either as first-line chemotherapy for high-risk gestational trophoblastic neoplasia (n = 6), placental site trophoblastic tumor (n = 1), or as salvage chemotherapy for gestational trophoblastic neoplasia after single-agent methotrexate (methotrexate, 1 mg/kg, on days 1, 3, 5, and 7 every two weeks) (n = 10) or high-dose methotrexate-etoposide: methotrexate, 1000 mg/m, on day 1; etoposide, 100 mg/m, on days 1 to 2, every week) (n = 1). "
01/01/1998 - "We document a case of long-term remission in a patient with metastatic placental site trophoblastic tumor (PSTT) and attempt to determine the response rate of metastatic PSTT to EMA/CO (etoposide, methotrexate, actinomycin-D, cyclophosphamide, and vincristine) combination chemotherapy based on available reports. "
02/01/2000 - "Etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors."
02/01/2000 - "To evaluate the results of etoposide, cisplatin/etoposide, methotrexate, and actinomycin D (EP/EMA) chemotherapy in patients with gestational trophoblastic tumors (GTTs), who have relapsed after or who have become refractory to EMA/cyclophosphamide and vincristine (CO) chemotherapy, and in patients presenting with metastatic placental site trophoblastic tumors (PSTTs). "
3. Vincristine (Oncovin)FDA LinkGeneric
4. Dactinomycin (Ac-De)FDA LinkGeneric
5. Cyclophosphamide (Cytoxan)FDA LinkGeneric
6. Carbon MonoxideIBA
7. Macrophage Colony-Stimulating FactorIBA
8. Fluorouracil (Carac)FDA LinkGeneric
9. DNA (Deoxyribonucleic Acid)IBA
10. ParaffinIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Combination Drug Therapy (Combination Chemotherapy)
3. Adjuvant Chemotherapy
4. Hysterectomy
5. Curettage